{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:23:29Z","timestamp":1787027009498,"version":"build-2736575974"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Non-invasive methods are needed to rapidly assess increased ICP, especially for managing patients when invasive devices are unavailable or contraindicated. This study aims to examine the diagnostic value of transcranial Doppler (TCD), ophthalmic ultrasound measurements, and near-infrared spectroscopy (NIRS) to define non-invasive ICP (nICP) in the evaluation of pediatric intensive care unit (PICU) patients with increased ICP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a Single center prospective case-control study. The study group comprised 32 pediatric patients with increased ICP, while the control group comprised 64 healthy children. The following non-invasive methods were measured prospectively: optic nerve sheath diameter (ONSD)-derived nICP (nICPONSD), central retinal artery Doppler indices, arterial TCD blood velocities, pulsatility index (PI)-derived nICP (nICPPI), Lindegaard ratio (L\/R), and NIRS values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean ONSD, retinal artery resistive index (RI), middle cerebral artery (MCA) RI, nICPONSD, and L\/R were significantly greater in the study group than the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.000,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.000,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.011,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.000,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.000, respectively). There was no significant correlation between ONSD and NIRS values or between MCA PI and NIRS values. The ONSD measurement was the strongest parameter, with an area under the curve (AUC) of 0.92 (95% CI\u2009=\u20090.884\u20130.986) and the best cut-off value being 5.27\u2005mm (sensitivity\u2009=\u200976.56%; specificity\u2009=\u200996.87%) for detecting increased ICP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The availability and utilization of both TCD and ophthalmic ultrasound methods have recently increased. This is the first pediatric report that focuses on comparing ONSD, TCD, and NIRS and evaluates the Doppler indices in patients with increased ICP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2025.1730891","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T06:41:44Z","timestamp":1767681704000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of near-infrared spectroscopy, transcranial Doppler, and ophthalmic ultrasound measurements in critically Ill pediatric patients with increased intracranial pressure"],"prefix":"10.3389","volume":"13","author":[{"given":"Damla Pinar","family":"Yavas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dincer","family":"Yildizdas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Misirlioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faruk","family":"Ekinci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faruk","family":"Incecik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozden","family":"Ozgur Horoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.3389\/fneur.2019.01261","article-title":"Approaches to multimodality monitoring in pediatric traumatic brain injury","volume":"10","author":"Appavu","year":"2019","journal-title":"Front Neurol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s13052-021-01035-2","article-title":"Evaluation of the relationship between NIRS (near-infrared spectroscopy) and optic nerve sheath diameter measurement in children with increased intracranial pressure: a pilot study","volume":"47","author":"Arslan","year":"2021","journal-title":"Ital J Pediatr"},{"key":"B3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s00381-019-04235-8","article-title":"Ultrasound non-invasive intracranial pressure assessment in paediatric neurocritical care: a pilot study","volume":"36","author":"Robba","year":"2020","journal-title":"Childs Nerv Syst"},{"key":"B4","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/PCC.0000000000002143","article-title":"Transcranial Doppler sonography in the PICU","volume":"21","author":"K\u00f6ro\u011flu","year":"2020","journal-title":"Pediatr Crit Care Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/978-3-7091-6837-0_35","article-title":"Near infrared spectroscopy (NIRS) in patients with severe brain injury and elevated intracranial pressure. 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