{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:16:13Z","timestamp":1789528573673,"version":"build-2803163510"},"reference-count":7,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Van Wyk\u2013Grumbach syndrome (VWGS) is a rare endocrine disorder caused by long-standing severe primary hypothyroidism, characterized by pseudoprecocious puberty and polycystic ovarian lesions. Owing to its overlapping features with central precocious puberty and ovarian tumors, misdiagnosis is common and may lead to unnecessary surgical intervention or delayed treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report the case of an 8-year-old girl who presented with vaginal bleeding. Physical examination revealed partial precocious puberty (Tanner stage 3). Laboratory evaluation demonstrated markedly elevated thyroid-stimulating hormone (TSH &amp;gt;150\u2005mIU\/mL) and decreased thyroid hormones, consistent with primary hypothyroidism. Imaging revealed symmetrical pituitary hyperplasia (vertical diameter \u224817.7\u2005mm) and large bilateral multilocular ovarian cysts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case emphasizes the necessity of routine thyroid function screening in the differential diagnosis of pediatric precocious puberty WITH POOR LINEAR GROWTH and ovarian cysts. The coexistence of pituitary hyperplasia, bilateral ovarian cysts, and severe biochemical hypothyroidism represents the diagnostic triad of VWGS. Prompt levothyroxine replacement therapy rapidly reversed clinical manifestations and imaging abnormalities, preventing unnecessary surgery. These findings provide key diagnostic insights for pediatric endocrinologists and radiologists.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2025.1736671","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:11:38Z","timestamp":1768205498000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Van Wyk\u2013Grumbach syndrome presenting as vaginal bleeding: diagnostic value of pituitary and pelvic imaging"],"prefix":"10.3389","volume":"13","author":[{"given":"Yuqing","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e61382","DOI":"10.7759\/cureus.61382","article-title":"Solving the dilemma: Van Wyk-Grumbach syndrome","volume":"16","author":"Rathod","year":"2024","journal-title":"Cur\u0113us"},{"key":"B2","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.jpag.2025.09.005","article-title":"Bridging the gap between hypothyroidism and precocious puberty: a case report of Van Wyk Grumbach syndrome","volume":"7","author":"Kumari","year":"2025","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/jendso\/bvad042","article-title":"Van Wyk Grumbach syndrome and ovarian hyperstimulation in juvenile primary hypothyroidism: lessons from a 30-case cohort","volume":"7","author":"Kusuma Boddu","year":"2023","journal-title":"J Endocr Soc"},{"key":"B4","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1297\/cpe.2025-0032","article-title":"Van Wyk-Grumbach syndrome: a case report and review of the literature","volume":"34","author":"Komatsu","year":"2025","journal-title":"Clin Pediatr Endocrinol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/s0022-3476(60)80250-8","article-title":"Syndrome of precocious menstruation and galactorrhea in juvenile hypothyroidism: an example of hormonal overlap in pituitary feedback","volume":"57","author":"Van Wyk","year":"1960","journal-title":"J Pediatr-US"},{"key":"B6","doi-asserted-by":"publisher","first-page":"110975","DOI":"10.1016\/j.ijscr.2025.110975","article-title":"Van Wyk-Grumbach syndrome with bilateral inguinal hernia: a case report","volume":"127","author":"Sivasubramanian","year":"2025","journal-title":"Int J Surg Case Rep"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15226\/2374-6890\/4\/3\/00179","article-title":"Van Wyk and Grumbach syndrome: an unusual presentation of acquired hypothyroidism","volume":"4","author":"Kacem","year":"2017","journal-title":"J Endocrinol Diabetes"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1736671\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:11:49Z","timestamp":1768205509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2025.1736671\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":7,"alternative-id":["10.3389\/fped.2025.1736671"],"URL":"https:\/\/doi.org\/10.3389\/fped.2025.1736671","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]},"article-number":"1736671"}}