{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:42:29Z","timestamp":1776235349805,"version":"3.50.1"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze clinical features of hepatic injury in children with EBV-associated infectious mononucleosis (EBV-IM) and identify its risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of the clinical data of children with EBV-IM admitted to the First Hospital of Jilin University from March 2023 to March 2025 was conducted. Confounding factors were balanced by propensity score matching (PSM). The children were divided into a hepatic injury group and a non-hepatic injury group. The risk factors were examined using binary logistic regression. Furthermore, the diagnostic performance of these risk factors was assessed and presented using receiver operating characteristic (ROC) curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After PSM, 52 pairs of patients were matched. Statistically significant differences in white blood cell count, the proportion of neutrophils, the proportion and absolute value of lymphocytes, the platelet\u2013to-lymphocyte ratio (PLR), hepatosplenomegaly, whole blood EBV DNA load &amp;gt;1\u2009\u00d7\u200910\n                      <jats:sup>5<\/jats:sup>\n                      copies\/mL, and total iron-binding capacity(TIBC) were detected(all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05). Multivariate logistic regression analysis revealed that TIBC and whole blood EBV DNA load &amp;gt;1\u2009\u00d7\u200910\n                      <jats:sup>5<\/jats:sup>\n                      copies\/mL were risk factors, whereas the PLR was a protective factor. ROC curve analysis showed that the cutoff values of TIBC and reciprocal platelet-to-lymphocyte ratio (rPLR) for the diagnosis of EBV-IM-related hepatic injury were 53.250\u2005\u03bcmol\/L and 0.052, with areas under the curve of 0.652 and 0.713, sensitivities of 69.2% and 53.8%, and specificities of 62.7% and 88.2%, and these two indicators could be used as diagnostic markers for hepatic injury in children with EBV-IM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      EBV-IM-related hepatic injury in children correlates with iron metabolism. TIBC and whole blood EBV DNA load (&amp;gt;1\u2009\u00d7\u200910\n                      <jats:sup>5<\/jats:sup>\n                      copies\/mL) are independent risk factors, whereas the PLR is a protective factor.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1727430","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:42:05Z","timestamp":1776231725000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["TIBC, PLR, and EBV DNA load correlate with hepatic injury in EBV-associated infectious mononucleosis"],"prefix":"10.3389","volume":"14","author":[{"given":"Shengfeng","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Outpatient and Emergency, Children's Medical Center, The First Hospital of Jilin University","place":["Changchun, 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