{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T22:41:59Z","timestamp":1780440119896,"version":"3.54.1"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Neonatal hyperbilirubinemia, affecting over 60% of term and 80% of preterm infants globally, remains a significant public health challenge due to the persistent risk of kernicterus despite effective management strategies. This narrative review summarizes global clinical practice guidelines to describe the evolution and current landscape of management, highlighting the disparity between evidence-based consensus and local adaptation. While universal principles such as early hyperbilirubinemia screening, phototherapy as the first-line treatment, and post-discharge follow-up are widely endorsed, substantial disparities exist in implementation\u2014particularly between high-income countries and low- and middle-income countries (LMICs)\u2014driven by differences in healthcare resources, sociocultural perceptions, and technological access. The 2025 Chinese guideline is an integrated model combining risk-stratified screening, locally derived hour-specific nomograms, online follow-up, and family engagement, offering a scalable framework for LMICs. Looking ahead, global harmonization may require a dual-layered guideline structure, affordable technology dissemination, culturally adapted family support systems, and inclusion of hyperbilirubinemia metrics in national health performance evaluations to achieve equitable and effective care worldwide.<\/jats:p>","DOI":"10.3389\/fped.2026.1745769","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:49:34Z","timestamp":1770360574000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Evolution and contemporary landscape of neonatal hyperbilirubinemia management guidelines: a narrative review"],"prefix":"10.3389","volume":"14","author":[{"given":"Yaxin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of the Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaowen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of the Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of the Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhua","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of the Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of the Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of the Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of the Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"699","DOI":"10.12968\/hmed.2017.78.12.699","article-title":"Neonatal jaundice: aetiology, diagnosis and treatment","volume":"78","author":"Mitra","year":"2017","journal-title":"Br J Hosp Med (Lond)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1282451","DOI":"10.3389\/fpubh.2023.1282451","article-title":"Measurement of the burdens of neonatal disorders in 204 countries, 1990\u20132019: a global burden of disease\u2013based study","volume":"11","author":"Xin","year":"2023","journal-title":"Front Public Health"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e000845","DOI":"10.1136\/bmjpo-2020-000845","article-title":"Management of neonatal jaundice in low income and middle income countries","volume":"4","author":"Erdeve","year":"2020","journal-title":"BMJ Paediatr Open"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e2022058859","DOI":"10.1542\/peds.2022-058859","article-title":"Clinical practice guideline revision: management of hyperbilirubinemia in the newborn infant \u226535 weeks gestation","volume":"150","author":"Kemper","year":"2022","journal-title":"Pediatrics"},{"key":"B5","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1136\/archdischild-2016-311556","article-title":"Jaundice in newborn babies under 28 days. 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