{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T13:51:42Z","timestamp":1772632302543,"version":"3.50.1"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the short-term clinical and echocardiographic effects of a first volume expansion in hypotensive preterm infants during the first 24\u2005h of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Single-center retrospective observational pilot study including preterm infants \u226431\u2009+\u20096 weeks of gestation, intubated and mechanically ventilated, presenting arterial hypotension within 24\u2005h of life. All infants received a first volume expansion with modified fluid gelatin (20\u2005mL\/kg). Clinical and echocardiographic parameters were compared immediately before and after volume expansion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-one infants were included. Volume expansion was associated with a significant increase in systolic, diastolic and mean arterial pressure (median MAP increase: +4\u2005mmHg; +17%), and a significant decrease in heart rate and capillary refill time. Echocardiographic assessment showed a significant increase in left ventricular end-diastolic diameter and superior vena cava flow (median increase: +19%), suggesting improved preload and systemic blood flow. No immediate clinically apparent adverse events were recorded during the observation period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this exploratory pilot study, a first volume expansion was associated with short-term improvements in clinical and echocardiographic hemodynamic parameters in hypotensive preterm infants. These findings are hypothesis-generating and cannot be generalized to current filling strategies or repeated fluid boluses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1749902","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T06:59:04Z","timestamp":1772607544000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and echocardiographic response to volume expansion in hypotensive preterm infants: a pilot observational study"],"prefix":"10.3389","volume":"14","author":[{"given":"Oc\u00e9ane","family":"Lalin","sequence":"first","affiliation":[{"name":"Neonatology Department, Maternit\u00e9 R\u00e9gionale Universitaire\u2014CHRU Nancy","place":["Nancy, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marc","family":"Jellimann","sequence":"additional","affiliation":[{"name":"Neonatology Department, Maternit\u00e9 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