{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:00:15Z","timestamp":1777950015206,"version":"3.51.4"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ulceration is a common complication of infantile hemangioma, and its management poses unique difficulties when the lesion is located in high-risk areas like the scrotum. This case report details the successful management of this condition using topical moist wound dressings combined with propranolol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 5-month-old male presented with a rapidly progressing, ulcerated scrotal infantile hemangioma characterized by purulent exudate. Systemic treatment involved oral propranolol solution (maintenance dose of 2\u2005mg\/kg\/d). Local wound care was managed using a tailored moist wound healing strategy: alginate dressing combined with recombinant human epidermal growth factor gel, secured with a transparent film dressing. The patient was treated successfully; localized infection was controlled within 3 days. The wound achieved complete epithelialization after a total of 12 days of consistent combined treatment, accompanied by simultaneous regression of the hemangioma volume. Three-month Follow-up confirmed favorable cosmetic results with no significant hypertrophic scarring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case underscores that a synergistic regimen of systemic propranolol and a customized moist wound healing strategy can significantly accelerate healing timelines and improve the quality of tissue repair in ulcerated infantile hemangiomas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1752616","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:33:21Z","timestamp":1777872801000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic propranolol and topical moist wound dressings for ulcerated infantile hemangioma of the scrotum: a case report"],"prefix":"10.3389","volume":"14","author":[{"given":"Jiejun","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunshan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyun","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shifeng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.arcped.2013.01.052","article-title":"H\u00e9mangiomes infantiles: actualit\u00e9s dans le traitement [infantile hemangioma: update and treatment]","volume":"20","author":"L\u00e9aut\u00e9-Labr\u00e8ze","year":"2013","journal-title":"Arch Pediatr"},{"key":"B2","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1001\/jamadermatol.2021.0469","article-title":"Clinical features, prognostic factors, and treatment interventions for ulceration in patients with infantile hemangioma","volume":"157","author":"Fern\u00e1ndez Faith","year":"2021","journal-title":"JAMA Dermatol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e20183475","DOI":"10.1542\/peds.2018-3475","article-title":"Clinical practice guideline for the management of infantile 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Int"},{"key":"B10","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1111\/iwj.12740","article-title":"Wound management of ulcerated haemangioma of infancy - an audit","volume":"14","author":"Lokmic","year":"2017","journal-title":"Int Wound J"},{"key":"B11","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1089\/wound.2020.1232","article-title":"Moist wound healing with commonly available dressings","volume":"10","author":"Nuutila","year":"2021","journal-title":"Adv Wound Care (New Rochelle)"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1752616\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:33:22Z","timestamp":1777872802000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1752616\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,4]]},"references-count":11,"alternative-id":["10.3389\/fped.2026.1752616"],"URL":"https:\/\/doi.org\/10.3389\/fped.2026.1752616","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,4]]},"article-number":"1752616"}}