{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:03:01Z","timestamp":1784872981748,"version":"3.55.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the safety and feasibility of laparoscopic liver resection (LLR) for pediatric liver tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Web of Science, Cochrane Library, Embase, and Chinese databases (CNKI, WanFang, VIP) for studies on LLR for pediatric liver tumors. Following PRISMA guidelines, nine studies (144 LLR patients) were selected and evaluated using the Methodological Index for Non-Randomized Studies (MINORS). Meta-analysis of single-arm proportions and continuous variables was conducted using R 4.4.1, with comparative analysis against open liver resection (OLR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The pooled mean maximum tumor diameter was 5.69\u2005cm (95% CI: 4.85\u20136.53). Mean operative time was 208.77\u2005min (95% CI: 153.74\u2013263.80), and intraoperative blood loss 88.80\u2005mL (95% CI: 31.33\u2013146.27). Transfusion proportion was 32% (95% CI: 16%\u201354%), hospital stay was 6.8 days (95% CI: 4\u20139.6), and the overall postoperative complications 16% (95% CI: 10%\u201324%) including 11% bile leakage (95% CI: 6%\u201319%). Notably, no gas embolism or port site metastasis occurred. The hepatoblastoma recurrence proportion was 9% (95% CI: 5%\u201319%). LLR required significantly longer operative time (+60.02\u2005min;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.0001) but achieved significantly shorter hospitalization (\u22122.76 days;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.0001) compared to OLR. Intraoperative blood loss did not differ significantly between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.7138).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LLR appears safe and feasible for pediatric liver tumors in selected patients. Limited evidence and heterogeneous patient selection warrant propensity score matching and multicenter prospective studies to establish surgical indications and long-term oncologic outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1756373","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:35:40Z","timestamp":1784871340000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Laparoscopic liver resection for pediatric liver tumors: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"14","author":[{"given":"Hanlei","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, The Second Affiliated Hospital, Xi\u2019an Jiaotong University","place":["Xi\u2019an, China"]},{"name":"Institute of Neurobiology, Environment and Genes Related to Diseases Key Laboratory of Chinese Ministry of Education, Xi'an Jiaotong University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baijun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The Second Affiliated Hospital, Xi\u2019an Jiaotong University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghao","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The Second Affiliated Hospital, Xi\u2019an Jiaotong University","place":["Xi\u2019an, China"]},{"name":"Institute of Neurobiology, Environment and Genes Related to Diseases Key Laboratory of Chinese Ministry of Education, Xi'an Jiaotong University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The Second Affiliated Hospital, Xi\u2019an Jiaotong University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.cld.2018.06.008","article-title":"Pediatric liver tumors","volume":"22","author":"Ng","year":"2018","journal-title":"Clin Liver Dis"},{"key":"B2","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1002\/jhbp.261","article-title":"Long-term and perioperative outcomes of laparoscopic versus open liver resection for colorectal liver metastases with propensity score matching: a multi-institutional Japanese study","volume":"22","author":"Beppu","year":"2015","journal-title":"J Hepato-Biliary-Pancreat Sci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"A5","DOI":"10.1016\/j.suronc.2017.12.003","article-title":"Practical guidelines for performing laparoscopic liver resection based on the second international laparoscopic liver consensus conference","volume":"27","author":"Cho","year":"2018","journal-title":"Surg Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.surg.2018.01.020","article-title":"Laparoscopic versus open major hepatectomy: a systematic review and meta-analysis of individual patient data","volume":"163","author":"Kasai","year":"2018","journal-title":"Surgery"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijsu.2018.11.021","article-title":"Laparoscopic vs. Open left lateral sectionectomy: an update meta-analysis of randomized and non-randomized controlled trials","volume":"61","author":"Macacari","year":"2019","journal-title":"Int J Surg Lond Engl"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e25","DOI":"10.1016\/j.jpedsurg.2005.10.068","article-title":"Total laparoscopic left lateral sectionectomy performed in a child with benign liver mass","volume":"41","author":"Yoon","year":"2006","journal-title":"J Pediatr Surg"},{"key":"B7","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3760\/cma.j.issn.0253-3006.2007.02.016","article-title":"Proceedings of the first national conference on pediatric experimental surgery and clinical new technologies","volume":"28","author":"Yuan","year":"2007","journal-title":"Chin J Pediatr Surg"},{"key":"B8","doi-asserted-by":"publisher","first-page":"A","DOI":"10.1089\/lap.2018.29025.abstracts","article-title":"Result of pediatric laparoscopic liver resection: a report of 15 cases. 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