{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T07:29:02Z","timestamp":1771399742208,"version":"3.50.1"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Sepsis in children with acute lymphoblastic leukemia (ALL) is associated with high mortality and a frequent need for advanced organ support; therefore, reliable scoring systems are required to stratify risk in the pediatric intensive care unit (PICU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the performance of the Phoenix-8 and PELOD-2 scales, measured at 24 and 72\u2005h after admission, for predicting 28-day mortality in children with ALL and sepsis or septic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study including 61 patients aged 1 month to 18 years with ALL admitted to the PICU of a quaternary-level hospital in Bogot\u00e1, Colombia, between 2022 and 2024. Phoenix-8 and PELOD-2 scores were calculated at 24 and 72\u2005h after admission. Receiver operating characteristic (ROC) curves, optimal cutoff points, sensitivity, and specificity were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-eight-day mortality was 23.0%; 27.9% of patients required invasive mechanical ventilation and 63.9% required vasoactive support. At 72\u2005h, a PELOD-2 score \u22657 showed an area under the ROC curve (AUC) of 0.945, with a sensitivity of 92.9% and specificity of 91.1%. A Phoenix-8 score \u22658 achieved an AUC of 0.976, with a sensitivity of 92.9% and specificity of 91.3%, and was significantly associated with the use of mechanical ventilation, vasoactive agents, and renal replacement therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Phoenix-8 and PELOD-2 demonstrated moderate discriminative ability at admission but excellent performance at 72\u2005h, making them clinically useful and comparable tools for prognostic stratification in children with ALL and sepsis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1766687","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:55:04Z","timestamp":1771397704000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Utility of the Phoenix-8 and PELOD-2 scales in pediatric patients with sepsis and acute lymphoblastic leukemia admitted to a pediatric intensive care unit at a quaternary-level hospital in Bogot\u00e1, Colombia, 2022\u20132024"],"prefix":"10.3389","volume":"14","author":[{"given":"Ludwing Jose","family":"Gallo-Motta","sequence":"first","affiliation":[{"name":"Pediatric Intensivist, Fundaci\u00f3n HOMI","place":["Bogot\u00e1, Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela Maria","family":"Lince-Gonzalez","sequence":"additional","affiliation":[{"name":"Pediatric Intensivist, Fundaci\u00f3n HOMI","place":["Bogot\u00e1, Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Lucia","family":"Bravo-Guerra","sequence":"additional","affiliation":[{"name":"Pediatric Intensivist, Fundaci\u00f3n HOMI","place":["Bogot\u00e1, Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Alberto","family":"Pardo Gonzalez","sequence":"additional","affiliation":[{"name":"Pediatric Hematologist-Oncologist, Fundaci\u00f3n HOMI","place":["Bogot\u00e1, Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Perez-Morales","sequence":"additional","affiliation":[{"name":"Pediatric Intensivist, Fundaci\u00f3n HOMI","place":["Bogot\u00e1, Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan D.","family":"Roa G","sequence":"additional","affiliation":[{"name":"Pediatric Neurologist, Pediatric Intensivist, Fundaci\u00f3n HOMI","place":["Bogot\u00e1, Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1001\/jama.2024.0179","article-title":"International consensus criteria for pediatric sepsis and septic 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