{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:13:14Z","timestamp":1771485194039,"version":"3.50.1"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Neonatal hyperthyroidism (NH) is a rarely reported condition, but inappropriate treatment can have serious consequences. Early diagnosis, treatment, and follow-up are, therefore, essential. We present the case of a male newborn who was admitted to the Pediatrics Department 24\u2005min after birth due to prematurity, presenting with tachypnea and grunting for 20\u2005min. Subsequently, the infant developed increased respiratory rate, tachycardia, crying, and irritability. Bilateral periorbital edema and hyperdynamic heart sounds were also noted. Myocardial injury markers were significantly elevated, indicating myocardial injury. Following treatment with dopamine and dobutamine, the heart rate decreased, but crying, irritability, and periorbital edema persisted. Further history-taking led to a diagnosis of NH with neonatal goiter. The infant was started on oral methimazole and propranolol. Three days after initiation of therapy, the symptoms resolved rapidly, and the patient was discharged.<\/jats:p>","DOI":"10.3389\/fped.2026.1767859","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:42:18Z","timestamp":1771483338000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neonatal hyperthyroidism with myocardial injury: a case report"],"prefix":"10.3389","volume":"14","author":[{"given":"Tian","family":"Junhua","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Ningbo Zhenhai People\u2019s Hospital","place":["Ningbo, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Qiuyan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Ningbo Zhenhai People\u2019s Hospital","place":["Ningbo, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Ranfeng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ningbo Zhenhai People\u2019s Hospital","place":["Ningbo, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.yapd.2022.04.004","article-title":"Update on pediatric hyperthyroidism","volume":"69","author":"Vaidyanathan","year":"2022","journal-title":"Adv Pediatr"},{"key":"B2","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1515\/JPEM.2008.21.5.479","article-title":"Congenital neonatal hyperthyroidism caused by germline mutations in the TSH receptor gene: case report and review of the literature","volume":"21","author":"Chester","year":"2008","journal-title":"J Pediatr Endocrinol Metab"},{"key":"B3","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1530\/EJE-20-1320","article-title":"Prevalence and course of thyroid dysfunction in neonates at high risk of graves\u2019 disease or with non-autoimmune hyperthyroidism","volume":"184","author":"Benlarbi","year":"2021","journal-title":"Eur J Endocrinol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1046\/j.1365-2265.2001.01224.x","article-title":"Effect of maternal hyperthyroidism during late pregnancy on the risk of neonatal low birth weight","volume":"54","author":"Phoojaroenchanachai","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.beem.2004.03.005","article-title":"Hyperthyroidism in pregnancy","volume":"18","author":"Mestman","year":"2004","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"B6","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1093\/aje\/kwt031","article-title":"Neonatal outcomes and birth weight in pregnancies complicated by maternal thyroid disease","volume":"178","author":"M\u00e4nnist\u00f6","year":"2013","journal-title":"Am J Epidemiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"15","DOI":"10.15605\/jafes.037.02.03","article-title":"Neonatal outcomes of pregnancies complicated by maternal hyperthyroidism","volume":"37","author":"Abdullah","year":"2022","journal-title":"J ASEAN Fed Endocr Soc"},{"key":"B8","doi-asserted-by":"publisher","first-page":"877119","DOI":"10.3389\/fendo.2022.877119","article-title":"Follow-up of thyroid function in children with neonatal hyperthyroidism","volume":"13","author":"Pyr\u017cak","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B9","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.jpeds.2018.01.071","article-title":"Prediction of neonatal hyperthyroidism","volume":"197","author":"Banig\u00e9","year":"2018","journal-title":"J Pediatr"},{"key":"B10","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1507\/endocrj.50.595","article-title":"Changes in serum TSH receptor antibody (TRAb) values in patients with graves\u2019 disease after total or subtotal thyroidectomy","volume":"50","author":"Takamura","year":"2003","journal-title":"Endocr J"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/EJE-10-0775","article-title":"Genetic hyperthyroidism: hyperthyroidism due to activating TSHR mutations","volume":"164","author":"Hebrant","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5152\/TurkPediatriArs.2017.2513","article-title":"Fetal neonatal hyperthyroidism: diagnostic and therapeutic approachment","volume":"52","author":"Kurto\u011flu","year":"2017","journal-title":"Turk Arch Pediatr T\u00fcrk Pediatri Ar\u015fivi"},{"key":"B13","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1001\/archpedi.1977.02120140070012","article-title":"Neonatal hyperthyroidism and heart failure: a differential approach","volume":"131","author":"Lightner","year":"1977","journal-title":"Am J Dis Children"},{"key":"B14","doi-asserted-by":"publisher","first-page":"\u0421.1","DOI":"10.4172\/2161-1017.1000166","article-title":"Role of thyroid hormones in different aspects of cardiovascular system","volume":"4","author":"Hernando","year":"2015","journal-title":"Endocrinol Metab Synd"},{"key":"B15","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1093\/clinchem\/hvab063","article-title":"Cardiac biomarkers in pediatrics: an undervalued resource","volume":"67","author":"Bohn","year":"2021","journal-title":"Clin Chem"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.3390\/diagnostics13193028","article-title":"Data analysis and systematic scoping review on the pathogenesis and modalities of treatment of thyroid storm complicated with myocardial involvement and shock","volume":"13","author":"Elmenyar","year":"2023","journal-title":"Diagnostics"},{"key":"B17","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s40560-021-00548-6","article-title":"Cardiac biomarkers in acute respiratory distress syndrome: a systematic review and meta-analysis","volume":"9","author":"Jayasimhan","year":"2021","journal-title":"J Intensive Care"},{"key":"B18","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3390\/diagnostics15020165","article-title":"Cardiac markers in pediatric laboratory medicine: critical review","volume":"15","author":"Zrinski Topic","year":"2025","journal-title":"Diagnostics"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1767859\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:42:19Z","timestamp":1771483339000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1767859\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,19]]},"references-count":18,"alternative-id":["10.3389\/fped.2026.1767859"],"URL":"https:\/\/doi.org\/10.3389\/fped.2026.1767859","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,19]]},"article-number":"1767859"}}