{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:49:54Z","timestamp":1773269394680,"version":"3.50.1"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peutz\u2013Jeghers syndrome (PJS) is a rare autosomal dominant disorder characterized by mucocutaneous pigmentation and gastrointestinal hamartomatous polyposis, predisposing affected individuals to recurrent small bowel intussusception and increased cancer risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report two siblings with genetically confirmed PJS who presented with intestinal obstruction due to small bowel intussusception. The first, a 13-year-old girl, had necrotic ileal intussusception caused by a large polyp requiring segmental resection. Her younger brother had jejuno-jejunal intussusception secondary to multiple intraluminal polyps, managed by manual reduction and polyp extraction. Histopathological examination revealed characteristic hamartomatous Peutz\u2013Jeghers polyps with villous architecture and arborizing bundles of compact smooth muscle. Genetic analysis confirmed a pathogenic STK11\/LKB1 mutation in both patients. At 5-year follow-up, both remained asymptomatic under regular endoscopic and imaging surveillance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PJS should be suspected in children presenting with recurrent small bowel intussusception, particularly with mucocutaneous pigmentation or a positive family history. Early diagnosis, bowel-preserving surgery, and long-term multidisciplinary follow-up are key to preventing recurrence and malignant transformation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1768468","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:14:48Z","timestamp":1773213288000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Familial pediatric Peutz\u2013Jeghers syndrome with recurrent intussusception: case report and literature review"],"prefix":"10.3389","volume":"14","author":[{"given":"Sondes","family":"Sahli","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Children Hospital Tunis","place":["Tunis, Tunisia"]},{"name":"Universite de Tunis El Manar Faculte de Medecine de Tunis","place":["Tunis, Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bochra","family":"Aziza","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Children Hospital Tunis","place":["Tunis, Tunisia"]},{"name":"Universite de Tunis El Manar Faculte de Medecine de Tunis","place":["Tunis, Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Sghairoun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Children Hospital Tunis","place":["Tunis, Tunisia"]},{"name":"Universite de Tunis El Manar Faculte de Medecine de Tunis","place":["Tunis, Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Slimani","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Children Hospital Tunis","place":["Tunis, Tunisia"]},{"name":"Universite de Tunis El Manar Faculte de Medecine de Tunis","place":["Tunis, Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Boujelbene","sequence":"additional","affiliation":[{"name":"Universite de Tunis El Manar Faculte de Medecine de Tunis","place":["Tunis, Tunisia"]},{"name":"Institut Salah Azaiez","place":["Tunis, Tunisia"]},{"name":"Universite de Tunis El Manar Faculte des Sciences de Tunis","place":["Tunis, Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rim","family":"Missaoui","sequence":"additional","affiliation":[{"name":"Universite de Tunis El Manar Faculte de Medecine de Tunis","place":["Tunis, Tunisia"]},{"name":"Institut Salah Azaiez","place":["Tunis, Tunisia"]},{"name":"Universite de Tunis El Manar Faculte des Sciences de Tunis","place":["Tunis, Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohra","family":"Rahal","sequence":"additional","affiliation":[{"name":"Universite de Tunis El Manar Faculte de Medecine de Tunis","place":["Tunis, 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