{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:54:50Z","timestamp":1776318890706,"version":"3.50.1"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"\n Background<\/jats:title>\n This study aimed to compare the clinical efficacy of quarterly (15\u2005mg\/90 days) versus monthly (3.75\u2005mg\/28 days) triptorelin formulations with respect to bone maturation, predicted adult height (PAH), and hormonal suppression in Chinese girls with central precocious puberty (CPP).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This retrospective cohort study included 70 girls diagnosed with CPP at Fuzhou First General Hospital from March 2023 to 2025. Participants were assigned to either a quarterly regimen (triptorelin 15\u2005mg every 90 days,\n n<\/jats:italic>\n \u2009=\u200932) or a monthly regimen (triptorelin 3.75\u2005mg every 28 days,\n n<\/jats:italic>\n \u2009=\u200938). The evaluated outcomes included bone age (BA; TW3 method), PAH, serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) concentrations, uterine and ovarian volumes, body mass index (BMI), and adverse events, assessed at baseline, 6 months, and 12 months.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n After 12 months of treatment, both regimens achieved effective and comparable suppression of LH (quarterly: 0.30\u2009\u00b1\u20090.19\u2005IU\/L; monthly: 0.30\u2009\u00b1\u20090.26\u2005IU\/L; both\n P<\/jats:italic>\n \u2009\n &lt;<\/jats:italic>\n \u20090.001 vs. baseline) and FSH (quarterly:1.22\u2009\u00b1\u20090.91\u2005IU\/L; monthly: 1.31\u2009\u00b1\u20090.65\u2005IU\/L;\n P<\/jats:italic>\n \u2009\n &lt;<\/jats:italic>\n \u20090.05 vs. baseline). Improvements in PAH were also comparable between groups (quarterly: 3.95\u2009\u00b1\u20092.97\u2005cm; monthly: 2.91\u2009\u00b1\u20092.70\u2005cm;\n P<\/jats:italic>\n \u2009\n =<\/jats:italic>\n \u20090.790). No significant between-group differences were observed in BA maturation, growth velocity, or uterine and ovarian volumes (\n P<\/jats:italic>\n \u2009\n &gt;<\/jats:italic>\n \u20090.05). BMI increased significantly in both groups (quarterly: from 16.96\u2009\u00b1\u20092.10 to 17.89\u2009\u00b1\u20092.53\u2005kg\/m\n 2<\/jats:sup>\n ,\n P<\/jats:italic>\n \u2009=\u20090.01; monthly: from 16.89\u2009\u00b1\u20092.06 to 17.50\u2009\u00b1\u20092.03\u2005kg\/m\n 2<\/jats:sup>\n ,\n P<\/jats:italic>\n \u2009=\u20090.008), with no significant differences between regimens. Three patients experiencing a \u201cflare-up\u201d had a larger mean baseline uterine volume (6.95\u2005mL) compared with the remaining 67 patients (2.38\u2005mL).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Quarterly triptorelin demonstrated efficacy comparable to that of monthly administration in suppressing puberty and improving PAH in Chinese girls with CPP.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fped.2026.1774350","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:24:48Z","timestamp":1776317088000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative efficacy of quarterly vs. monthly triptorelin in Chinese girls with central precocious puberty: a 12-month observational study"],"prefix":"10.3389","volume":"14","author":[{"given":"Hongyi","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Genetics, and Metabolic Diseases, Fuzhou First General Hospital Affilliated with Fujian Medical University, Fuzhou Children\u2019s Hospital","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics, and Metabolic Diseases, Fuzhou First General Hospital Affilliated with Fujian Medical University, Fuzhou Children\u2019s Hospital","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics, and Metabolic Diseases, Fuzhou First General Hospital Affilliated with Fujian Medical University, Fuzhou Children\u2019s Hospital","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics, and Metabolic Diseases, Fuzhou First General Hospital Affilliated with Fujian Medical University, Fuzhou Children\u2019s Hospital","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics, and Metabolic Diseases, Fuzhou First General Hospital Affilliated with Fujian Medical University, Fuzhou Children\u2019s Hospital","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics, and Metabolic Diseases, Fuzhou First General Hospital Affilliated with Fujian Medical University, Fuzhou Children\u2019s Hospital","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuanzhuan","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics, and Metabolic Diseases, Fuzhou First General Hospital Affilliated with Fujian Medical University, Fuzhou Children\u2019s Hospital","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics, and Metabolic Diseases, Fuzhou First General Hospital Affilliated with Fujian Medical University, Fuzhou Children\u2019s Hospital","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruimin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics, and Metabolic Diseases, Fuzhou First General Hospital Affilliated with Fujian Medical University, Fuzhou Children\u2019s Hospital","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1111\/cen.14475","article-title":"Central precocious puberty: recent advances in understanding the aetiology and in the clinical approach","volume":"95","author":"Maione","year":"2021","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1210\/clinem\/dgad081","article-title":"Approach to the patient: central precocious puberty","volume":"108","author":"Kilberg","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1007\/s00431-021-04022-1","article-title":"Diagnosis and management of precocious sexual maturation: an updated review","volume":"180","author":"Cheuiche","year":"2021","journal-title":"Eur J 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