{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:09:16Z","timestamp":1773644956503,"version":"3.50.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2023\u7a7a\u519b\u57fa\u57301079"],"award-info":[{"award-number":["2023\u7a7a\u519b\u57fa\u57301079"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2024\u7a7a\u519b\u57fa\u5730657"],"award-info":[{"award-number":["2024\u7a7a\u519b\u57fa\u5730657"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Left ventricular non-compaction (LVNC) is a rare type of cardiomyopathy. It is more difficult to diagnose during the neonatal period. This study reported the clinical manifestations of neonatal LVNC at initial diagnosis and investigated their short-term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cohort of 10 neonates was enrolled. Their clinical characteristics were analyzed, and follow-up was conducted for 1 year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The neonates had an average gestational age of 35.82 weeks and an average birth weight of 2,636\u2005g. The average age at initial diagnosis was 12 days and clinical manifestations were highly variable, ranging from asymptomatic (20%) to cyanosis (50%), dyspnea (50%), arrhythmia (60%), and heart failure (30%). Plasma myocardial injury markers were elevated, and electrocardiogram abnormalities were present in 90% of infants. Echocardiography revealed an average left ventricular (LV) non-compacted\/compacted ratio of 2.96 and reduced systolic function (ejection fraction: 38.5%; fractional shortening: 18.8%). The average LV internal diameters were both above the normative reference intervals, with an end-diastolic diameter of 2.26\u2005cm and an end-systolic diameter of 1.84\u2005cm. During follow-up, two neonates died. Among the eight survivors, three with non-isolated LVNC underwent cardiac surgery, whereas five were asymptomatic with normal LV systolic function at 1 year of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The clinical presentation of neonatal LVNC varies widely, from asymptomatic to those with dyspnea, cyanosis, arrhythmia, or heart failure. In our cohort, heart failure at initial diagnosis was associated with a poorer prognosis. Short-term follow-up suggested that with aggressive management, myocardial function may show signs of reversibility in a subset of neonates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1774991","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T06:36:38Z","timestamp":1773642998000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical characteristics and short-term outcomes of left ventricular non-compaction cardiomyopathy in neonates"],"prefix":"10.3389","volume":"14","author":[{"given":"Yan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatric, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Union 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