{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:38:53Z","timestamp":1792593533450,"version":"4.5.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Surgical intervention after air enema for paediatric intussusception is very common, and prompt surgical treatment after failure of air enema therapy is the key to reducing serious complications, such as intestinal perforation and intestinal necrosis caused by intussusception. The aim of this study was to develop and validate a prediction model for surgical intervention after air enema in paediatric intussusception to reduce the incidence of serious complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was performed on 843 children who were successfully reduced by air enema and 120 children who underwent surgical intervention after air enema in our hospital from January 2011 to December 2021. Baseline information, clinical presentation and test results of the children on admission were recorded. Univariate and multivariate logistic regression analyses were used to identify independent risk factors for surgical intervention after air enema for paediatric intussusception. Meanwhile, we developed a predictive model to predict surgical intervention after air enema for paediatric intussusception based on independent risk factors and validated the model using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Age, duration of symptoms, bloody stools, body temperature, lymphocyte percentage and basophil percentage were independently associated with the composite endpoint (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05). The patients were randomly divided into a training set and a validation set at a ratio of 7:3 for model construction and validation, respectively. A logistic regression model was constructed based on the above six factors and integrated into the nomogram. The area under the ROC curve of the nomogram constructed by 6 independent risk factors reached 0.879, and the calibration curve was close to the ideal diagonal. In addition, DCA analysis revealed significant net benefits of the model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our predictive model for surgical intervention after air enema in pediatric intussusception, developed using objectively measurable indicators, demonstrates reliable predictive capability. It provides clinicians with an effective and dependable tool for early decision-making regarding post-enema treatment strategies\u2014whether to continue with enema or proceed to surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1775369","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:55:33Z","timestamp":1772693733000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Development of a predictive model for surgical intervention following air enema reduction of pediatric intussusception"],"prefix":"10.3389","volume":"14","author":[{"given":"Min","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, The Sixth Affiliated Hospital of Harbin Medical University","place":["Harbin, China"]},{"name":"Department of Pediatric Surgery, The First Affiliated Hospital of Shantou University Medical College","place":["Shantou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfeng","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Huang","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department, Shenzhen Nanshan People\u2019s Hospital (Nanshan Hospital Affiliated to Shenzhen University)","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The First Affiliated Hospital of Shantou University Medical College","place":["Shantou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The Sixth Affiliated Hospital of Harbin Medical University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjun","family":"Rao","sequence":"additional","affiliation":[{"name":"Wangjing Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouxing","family":"Duan","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department, Shenzhen Nanshan People\u2019s Hospital (Nanshan Hospital Affiliated to Shenzhen University)","place":["Shenzhen, Guangdong, China"]},{"name":"Department of Pediatric Surgery, The First Affiliated Hospital of Shantou University Medical College","place":["Shantou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingbo","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The Sixth Affiliated Hospital of Harbin Medical University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.21037\/tp-23-269","article-title":"Risk factors and predictive models for early recurrent intussusception in children: a retrospective cohort study","volume":"12","author":"Yang","year":"2023","journal-title":"Transl Pediatr"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1092548","DOI":"10.3389\/fped.2023.1092548","article-title":"Developing a nomogram for predicting surgical intervention in pediatric intussusception after hydrostatic reduction","volume":"11","author":"Zhuang","year":"2023","journal-title":"Front Pediatr"},{"key":"B3","doi-asserted-by":"publisher","first-page":"368504211040911","DOI":"10.1177\/00368504211040911","article-title":"Effectiveness and safety of ultrasound-guided hydrostatic reduction for children with acute intussusception","volume":"104","author":"Yang","year":"2021","journal-title":"Sci Prog"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e18956","DOI":"10.1097\/MD.0000000000018956","article-title":"Sedative reduction method for children with intussusception","volume":"99","author":"Doo","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"B5","volume-title":"Pediatric Surgery","author":"Cai","year":"2014"},{"key":"B6","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S1875-9572(10)60055-1","article-title":"Epidemiology of childhood intussusception and determinants of recurrence and operation: analysis of national health insurance data between 1998 and 2007 in Taiwan","volume":"51","author":"Chen","year":"2010","journal-title":"Pediatr Neonatol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/PEC.0b013e3182587d12","article-title":"Factors associated with bowel resection among infants with intussusception in the United States","volume":"28","author":"Johnson","year":"2012","journal-title":"Pediatr Emerg Care"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1016\/j.jpedsurg.2016.09.033","article-title":"Predictors for bowel resection and the presence of a pathological lead point for operated childhood intussusception: a multi-center study","volume":"51","author":"Wong","year":"2016","journal-title":"J Pediatr Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.jamcollsurg.2013.02.033","article-title":"Pediatric specialist care is associated with a lower risk of bowel resection in children with intussusception: a population-based analysis","volume":"217","author":"McAteer","year":"2013","journal-title":"J Am Coll Surg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1016\/j.jpedsurg.2019.07.022","article-title":"Intussusception: a 14-year experience at a UK tertiary referral centre","volume":"55","author":"Ondhia","year":"2020","journal-title":"J Pediatr Surg"},{"key":"B11","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1097\/MPG.0000000000002487","article-title":"Tate J; African intussusception surveillance network. Risk factors associated with increased mortality from intussusception in African infants","volume":"70","author":"Pindyck","year":"2020","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"B12","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1080\/00015458.2021.1900521","article-title":"Ultrasound-guided hydrostatic reduction of ileo-colic intussusception in childhood: first-line management for both primary and recurrent cases","volume":"122","author":"Demirel","year":"2022","journal-title":"Acta Chir Belg"},{"key":"B13","volume-title":"Clinical Pathway of Acute Intussusception","year":"2019"},{"key":"B14","year":"2021"},{"key":"B15","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1080\/07853890.2021.1938661","article-title":"Risk factors and predictive model for abdominal wound dehiscence in neonates: a retrospective cohort study","volume":"53","author":"Duan","year":"2021","journal-title":"Ann Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.2147\/TCRM.S109785","article-title":"Prognostic indicators for failed nonsurgical reduction of intussusception","volume":"12","author":"Khorana","year":"2016","journal-title":"Ther Clin Risk Manag"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1542\/peds.2009-0466","article-title":"Prevention of rotavirus disease: updated guidelines for use of rotavirus vaccine","volume":"123","year":"2009","journal-title":"Pediatrics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1080\/21645515.2016.1197452","article-title":"Rotavirus vaccination and intussusception - science, surveillance, and safety: a review of evidence and recommendations for future research priorities in low and middle income countries","volume":"12","author":"Yen","year":"2016","journal-title":"Hum Vaccin Immunother"},{"key":"B19","first-page":"53","article-title":"Global advisory committee on vaccine safety, 11\u201312 December 2013","volume":"89","year":"2014","journal-title":"Wkly Epidemiol Rec"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.jpedsurg.2013.02.021","article-title":"Risk factors for surgery in pediatric intussusception in the era of pneumatic reduction","volume":"48","author":"Fallon","year":"2013","journal-title":"J Pediatr Surg"},{"key":"B21","first-page":"535","article-title":"Barium enema reduction of intussusception in a developing country","volume":"59","author":"Tota-Maharaj","year":"2010","journal-title":"West Indian Med J"},{"key":"B22","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1136\/adc.65.8.871","article-title":"Intussusception: factors related to treatment","volume":"65","author":"Reijnen","year":"1990","journal-title":"Arch Dis Child"},{"key":"B23","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.jpedsurg.2012.01.047","article-title":"Predictors of failed enema reduction in childhood intussusception","volume":"47","author":"Fike","year":"2012","journal-title":"J Pediatr Surg"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.7863\/ultra.33.9.1669","article-title":"Risk factors associated with failed sonographically guided saline hydrostatic intussusception reduction in children","volume":"33","author":"He","year":"2014","journal-title":"J Ultrasound Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1007\/s11605-019-04178-0","article-title":"Clinical characteristics of intussusception with surgical reduction: a single-center experience with 568 cases","volume":"23","author":"Hu","year":"2019","journal-title":"J Gastrointest Surg"},{"key":"B26","volume-title":"Internal Medicine","author":"Ge","year":"2019"},{"key":"B27","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.it.2024.05.009","article-title":"Basophil differentiation, heterogeneity, and functional implications","volume":"45","author":"Chen","year":"2024","journal-title":"Trends Immunol"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1775369\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:55:35Z","timestamp":1772693735000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1775369\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":27,"alternative-id":["10.3389\/fped.2026.1775369"],"URL":"https:\/\/doi.org\/10.3389\/fped.2026.1775369","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,5]]},"article-number":"1775369"}}