{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T22:09:29Z","timestamp":1772834969093,"version":"3.50.1"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Congenital midline sinus of the upper lip is rarest malformation with or without other anomalies. Mostly the sinus opens below the white role on the vermilion and has no intra-oral communication. To date, there have been only several case reports of upper lip sinuses associated with other anomalies, such as cleft palate or transverse facial cleft in China. We herein present a case of congenital upper lip sinus in the middle of the philtrum presenting as whitish discharge used to come out of it and review the current literature on this condition.<\/jats:p>","DOI":"10.3389\/fped.2026.1777126","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:08:47Z","timestamp":1772806127000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Midline congenital upper lip sinus: a rare clinical case with analytical review of diagnostic and therapy strategies"],"prefix":"10.3389","volume":"14","author":[{"given":"Shuang","family":"Yang","sequence":"first","affiliation":[{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Kang","sequence":"additional","affiliation":[{"name":"The First Hospital of China National Pharmaceutical Group (Yiji Hospital)","place":["Baotou, Inner Mongolia, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Hospital of China National Pharmaceutical Group (Yiji Hospital)","place":["Baotou, Inner Mongolia, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibo","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1597\/05-075.1","article-title":"Congenital isolated midline sinus of the upper lip: clinical and embryological approaches","volume":"43","author":"Charrier","year":"2006","journal-title":"Cleft Palate Craniofac J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1597\/1545-1569_2002_039_0457_ulftnc_2.0.co_2","article-title":"Upper lip fistulas: three new cases","volume":"39","author":"Sancho","year":"2002","journal-title":"Cleft Palate Craniofac J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/0030-4220(67)90067-9","article-title":"The syndrome of pits of the lower lip and cleft lip and\/or palate. 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