{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:02:25Z","timestamp":1780038145893,"version":"3.53.1"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>This case report presents a rare instance of a giant rapidly involuting congenital hemangioma (RICH) in a neonate. Prenatal ultrasound identified a placenta-like lesion on the right lower limb. Postnatally, a massive, dark purple tumor was observed. Imaging confirmed the diagnosis of RICH with no deep tissue involvement. The lesion underwent complete spontaneous involution within the first year of life without intervention, accompanied by transient thrombocytosis and ulceration during regression. This case demonstrates that even exceptionally large RICH lesions follow the classic, rapid involuting course. It underscores the importance of recognizing characteristic clinical and radiological features to adopt an active observation strategy, thereby avoiding unnecessary invasive treatments. The report highlights the roles of multidisciplinary management and long-term follow-up in ensuring optimal outcomes.<\/jats:p>","DOI":"10.3389\/fped.2026.1780760","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T06:11:03Z","timestamp":1780035063000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Giant rapidly involuting congenital hemangioma in a neonate: a case report"],"prefix":"10.3389","volume":"14","author":[{"given":"Jian","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasonics, Maternal and Child Health Care Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasonics, Maternal and Child Health Care Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasonics, Maternal and Child Health Care Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasonics, Maternal and Child Health Care Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuihua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasonics, Maternal and Child Health Care Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1111\/pde.13930","article-title":"Atypical presentations of congenital hemangiomas: extending the clinical phenotype","volume":"36","author":"West","year":"2019","journal-title":"Pediatr Dermatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/j.jaad.2020.01.069","article-title":"A case series of tardive expansion congenital hemangioma: a variation of noninvoluting congenital hemangioma or a new hemangiomatous entity?","volume":"84","author":"Hua","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"bcr-2018\u2013224337","DOI":"10.1136\/bcr-2018-224337","article-title":"Rapidly involuting congenital haemangioma of the liver","volume":"2018","author":"Lewis","year":"2018","journal-title":"BMJ Case Rep"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1148\/rg.2016150197","article-title":"2014 revised classification of vascular lesions from the international society for the study of vascular anomalies: radiologic-pathologic update","volume":"36","author":"Merrow","year":"2016","journal-title":"RadioGraphics"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e000816","DOI":"10.1136\/bmjpo-2020-000816","article-title":"Congenital haemangiomas: a single-centre retrospective review","volume":"4","author":"Braun","year":"2020","journal-title":"BMJPO"},{"key":"B6","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13244-019-0718-6","article-title":"Vascular tumors in infants and adolescents","volume":"10","author":"Wildgruber","year":"2019","journal-title":"Insights Imaging"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1007\/s00247-005-1557-9","article-title":"Imaging characteristics of two subtypes of congenital hemangiomas: rapidly involuting congenital hemangiomas and non-involuting congenital hemangiomas","volume":"35","author":"Gorincour","year":"2005","journal-title":"Pediatr Radiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e113","DOI":"10.1097\/JOVA.0000000000000113","article-title":"ISSVA vascular anomalies classification group. Updated classification of vascular anomalies. A living document from the international society for the study of vascular anomalies classification group","volume":"6","author":"Goldenberg","year":"2025","journal-title":"J Vasc Anom (Phila)"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.3390\/ijms23042358","article-title":"ISSVA classification of vascular anomalies and molecular biology","volume":"23","author":"Kunimoto","year":"2022","journal-title":"IJMS"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1111\/j.1365-2133.2008.08546.x","article-title":"Rapidly involuting congenital haemangioma associated with transient thrombocytopenia and coagulopathy: a case series","volume":"158","author":"Baselga","year":"2008","journal-title":"Br J Dermatol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e20173866","DOI":"10.1542\/peds.2017-3866","article-title":"Efficacy of propranolol between 6 and 12 months of age in high-risk infantile hemangioma","volume":"142","author":"Baselga","year":"2018","journal-title":"Pediatrics"},{"key":"B12","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1055\/s-0039-1688432","article-title":"A basic Introduction to pediatric vascular anomalies","volume":"36","author":"Eberson","year":"2019","journal-title":"Semin Intervent Radiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13023-020-1320-1","article-title":"Kaposiform hemangioendothelioma: current knowledge and future perspectives","volume":"15","author":"Ji","year":"2020","journal-title":"Orphanet J Rare Dis"},{"key":"B14","doi-asserted-by":"publisher","first-page":"20170798","DOI":"10.1259\/bjr.20170798","article-title":"Clinical and imaging features of kaposiform hemangioendothelioma","volume":"91","author":"Hu","year":"2018","journal-title":"Br J Radiol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/1346-8138.15270","article-title":"Conventional ultrasonography and elastography for the diagnosis of congenital and infantile hemangiomas","volume":"47","author":"Gong","year":"2020","journal-title":"J Dermatol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s10024-003-2134-6","article-title":"Rapidly involuting congenital hemangioma: clinical and histopathologic features","volume":"6","author":"Berenguer","year":"2003","journal-title":"Pediatr Dev Pathol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.jaad.2023.12.036","article-title":"Clinical features of rapid involuting congenital hemangioma: a prospective study","volume":"90","author":"Qiu","year":"2024","journal-title":"J Am Acad Dermatol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/his.14114","article-title":"The histopathology of congenital haemangioma and its clinical correlations: a long-term follow-up study of 55 cases","volume":"77","author":"El Zein","year":"2020","journal-title":"Histopathology"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1780760\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T06:11:03Z","timestamp":1780035063000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1780760\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":18,"alternative-id":["10.3389\/fped.2026.1780760"],"URL":"https:\/\/doi.org\/10.3389\/fped.2026.1780760","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"article-number":"1780760"}}