{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T06:42:52Z","timestamp":1776062572286,"version":"3.50.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>\n                    Severe community-acquired pneumonia caused by coinfection with\n                    <jats:italic>influenza A<\/jats:italic>\n                    virus and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ) is rare but may lead to rapid clinical deterioration and high mortality. We report two pediatric cases of severe pneumonia associated with\n                    <jats:italic>influenza A<\/jats:italic>\n                    virus-\n                    <jats:italic>S. aureus<\/jats:italic>\n                    coinfection. Both patients initially presented with nonspecific influenza-like symptoms, followed by rapid progression to acute respiratory failure. One case was characterized by necrotizing pneumonia complicated by pneumothorax and empyema, with\n                    <jats:italic>S. aureus<\/jats:italic>\n                    isolated from respiratory specimens and pleural fluid. The other case developed\n                    <jats:italic>S. aureus<\/jats:italic>\n                    bloodstream infection, progressing to septic shock and multiple organ dysfunction syndrome. Both children required prolonged invasive mechanical ventilation and multidisciplinary intensive care, including targeted antimicrobial therapy, organ support, and surgical intervention. Antimicrobial treatment consisted of vancomycin with adjunctive linezolid for 4\u20136 weeks. Despite severe disease, both patients achieved clinical recovery and were discharged, although residual pulmonary abnormalities were observed on follow-up. These cases highlight the heterogeneous clinical presentations of influenza-associated\n                    <jats:italic>S. aureus<\/jats:italic>\n                    coinfection in children. Early recognition, timely optimization of antimicrobial therapy, and comprehensive supportive management are essential to improve outcomes in this potentially life-threatening condition.\n                  <\/jats:p>","DOI":"10.3389\/fped.2026.1797919","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:44:09Z","timestamp":1776059049000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe pneumonia in children with influenza A\u2013Staphylococcus aureus coinfection: case report"],"prefix":"10.3389","volume":"14","author":[{"given":"Pei","family":"Tao","sequence":"first","affiliation":[{"name":"Chengdu Women and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China","place":["Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Wang","sequence":"additional","affiliation":[{"name":"Chengdu Women and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China","place":["Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghong","family":"Fan","sequence":"additional","affiliation":[{"name":"Chengdu Women and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China","place":["Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"B1","volume-title":"Pneumonia in Children","year":"2022"},{"key":"B2","volume-title":"Pneumonia","year":"2023"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1056\/NEJMc1504028","article-title":"Community-acquired pneumonia among U.S. 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