{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:55:25Z","timestamp":1775804125223,"version":"3.50.1"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study investigated the clinical characteristics, diagnostic considerations, and optimal management of a neonatal mature teratoma arising from an intra-abdominal cryptorchid testis complicated by torsion, a rare clinical entity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed data from a full-term male neonate admitted in November 2025 with a prenatally detected intra-abdominal mass, including postnatal imaging, tumor marker assessment, surgical excision, and pathological confirmation. Concurrently, we conducted a systematic review of English-language literature using PubMed, Embase, Cochrane Library, and Web of Science.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patient was diagnosed with a mature teratoma originating from an intra-abdominal cryptorchid testis. Intraoperative findings revealed 360\u00b0 clockwise torsion causing colonic compression. Complete resection resulted in an uneventful recovery, with a physiological decline in serum alpha-fetoprotein (AFP) levels consistent with postnatal age-related maturation, and no recurrence at one-month follow-up. The literature review identified ten cases (including the present case) of prenatally detected ultrasound-detected tumors with progressive tumor growth. Surgical management primarily involved laparoscopic surgery (40.0%) or laparotomy (60.0%). Mature teratomas were the predominant pathology (90.0%), tumor torsion occurred in 20.0% of cases, and no recurrences were reported, indicating a favorable prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Neonatal mature teratomas arising from an intra-abdominal cryptorchid testis with torsion are exceedingly rare. Evaluation of testicular position should be routine in male neonates with intra-abdominal masses, and gonadal tumors should be included in the differential diagnosis. Multidisciplinary, individualized management is essential for optimizing outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1802253","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:00:13Z","timestamp":1775800813000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neonatal mature teratoma arising from an intra-abdominal cryptorchid testis with torsion: a case report and literature review"],"prefix":"10.3389","volume":"14","author":[{"given":"Tong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University","place":["Xiamen, Fujian, China"]},{"name":"Pediatric Key Laboratory of Xiamen","place":["Xiamen, Fujian, 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