{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:10:05Z","timestamp":1784182205447,"version":"3.55.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To analyze the associations of inflammatory indices with laboratory-defined organ injury\/involvement and hospitalization length in pediatric respiratory tract infections (RTIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, logistic regression analyses were performed to examine the associations between inflammatory index levels and laboratory-defined cardiac injury, liver injury, and kidney involvement. Receiver operating characteristic (ROC) curve analyses were performed to evaluate the discriminative ability of inflammatory indices for laboratory-defined organ injury\/involvement. Linear regression analyses were conducted to assess the associations between inflammatory index levels and hospitalization length.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lower levels of neutrophils, C-reactive protein (CRP), Systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-platelet ratio (NPR), and CRP-to-lymphocyte ratio (CLR) were associated with the presence of laboratory-defined cardiac injury. Higher lymphocyte levels and lower levels of neutrophils, platelets, CRP, SII, NLR, platelet-to-lymphocyte ratio (PLR), NPR, and CLR were associated with the presence of laboratory-defined liver injury. Higher levels of white blood cells (WBCs), neutrophils, CRP, SII, NLR, PLR, and CLR, together with lower lymphocyte levels, were associated with the presence of laboratory-defined kidney involvement. ROC curve analyses suggested that NLR, SII, and CLR had a relatively high discriminative ability for laboratory-defined cardiac injury; SII, NLR, and PLR for liver injury; and NLR, CLR, and NPR for laboratory-defined kidney involvement. Higher levels of WBCs, lymphocytes, CRP, NPR, and CLR, along with lower levels of platelets and Hb, were associated with longer hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Inflammatory indices, particularly composite indices, were associated with laboratory-defined organ injury\/involvement and longer hospitalization in children with RTIs, suggesting their potential value as non-invasive exploratory markers. Future longitudinal studies are needed to confirm their prognostic utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1804507","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:40:04Z","timestamp":1784180404000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Differentiated associations of inflammatory indices with laboratory-defined organ injury\/involvement and hospitalization length in pediatric respiratory tract infections"],"prefix":"10.3389","volume":"14","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruotong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of 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