{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:54:50Z","timestamp":1790283290803,"version":"4.1.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review and meta-analysis aimed to identify prognostic factors influencing hearing recovery in children with sudden sensorineural hearing loss (SSNHL), thereby providing a reference for developing prevention strategies and optimizing therapeutic interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a comprehensive search of PubMed, Web of Science, Cochrane Library, Embase, CNKI, and SinoMed databases to identify relevant studies published prior to 2024. Inclusion criteria encompassed pediatric patients with SSNHL (&amp;lt;18 years old) who had clearly documented audiological outcomes. We extracted data on demographic characteristics, clinical features, and treatment regimens to investigate the association between prognostic factors and hearing recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This meta-analysis included 1,006 patients from 13 studies. The combined rates for partial and complete hearing recovery were 19.6% [95% confidence interval (CI): 13.6\u201325.7%,\n                      <jats:italic>\n                        <jats:bold>I\u00b2<\/jats:bold>\n                      <\/jats:italic>\n                      \u2009=\u200980.63%] and 18.6% (95% CI: 12.2\u201325.1%,\n                      <jats:italic>\n                        <jats:bold>I\u00b2<\/jats:bold>\n                      <\/jats:italic>\n                      \u2009=\u200985.99%), respectively. Better prognosis was associated with unilateral hearing loss [odds ratio (OR): 2.741,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004], age &amp;gt;12 years (OR: 1.911,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.034), treatment delay\u2009\u2264\u200914 days (OR: 6.402,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001), and an ascending audiogram curve (OR: 6.910,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). Conversely, poorer outcomes were associated with profound hearing loss curves (OR: 0.376,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001) and initial pure-tone average (PTA) thresholds &amp;gt;80\u2005dB HL (OR: 0.451,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early intervention (\u226414 days) and targeted treatment for profound hearing loss (PTA &amp;gt; 80\u2005dB HL) hold promise for improving pediatric outcomes. Systemic inflammatory markers (neutrophil-to-lymphocyte ratio) and age-specific pathophysiological mechanisms warrant further investigation. Conducting multicenter prospective studies is essential to validate these findings and establish standardized diagnostic and treatment protocols for pediatric SSNHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD42024612409<\/jats:ext-link>\n                      , CRD42024612409.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1808182","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:06:56Z","timestamp":1777442816000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic factors for pediatric sudden sensorineural hearing loss: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"14","author":[{"given":"Zongyi","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Endoscopic Ear Surgery, Senior Department of Otorhinolaryngology Head and Neck Surgery, The Sixth Medical Center of PLA General Hospital of Beijing","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peili","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endoscopic Ear Surgery, Senior Department of Otorhinolaryngology Head and Neck Surgery, The Sixth Medical Center of PLA General Hospital of Beijing","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Peking University International Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfang","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Endoscopic Ear Surgery, Senior Department of Otorhinolaryngology Head and Neck Surgery, The Sixth Medical Center of PLA General Hospital of Beijing","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.ijporl.2016.07.003","article-title":"Pediatric sudden sensorineural hearing loss: etiology, diagnosis and treatment in 20 children","volume":"88","author":"Dedhia","year":"2016","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"418","DOI":"10.3969\/j.issn.1006-7299.2013.04.029","article-title":"Research progress on clinical characteristics and prognosis of sudden deafness patients across different age groups","volume":"21","author":"Hou","year":"2013","journal-title":"J Audio Speech Pathol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.ijporl.2005.01.015","article-title":"Idiopathic sudden sensorineural hearing loss in children","volume":"69","author":"Chen","year":"2005","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1097\/mao.0000000000000222","article-title":"Incidence of sudden sensorineural hearing loss","volume":"34","author":"Alexander","year":"2013","journal-title":"Otol Neurotol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.15406\/joentr.2024.16.00548","article-title":"Sudden sensorineural hearing loss: a review","volume":"16","author":"Juan","year":"2024","journal-title":"J Otolaryngol ENT Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ijporl.2015.12.022","article-title":"Sudden sensorineural hearing loss in children: etiology, management, and outcome","volume":"82","author":"Pitaro","year":"2016","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"64","DOI":"10.5152\/iao.2020.8902","article-title":"Paediatric sudden sensorineural hearing loss. 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