{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:01:41Z","timestamp":1780038101552,"version":"3.53.1"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pediatric arrhythmias are heterogeneous and differ from adult disease in presentation and management; evidence from geographically vast, resource-variable regions of northwestern China remains limited, particularly in settings where access to pediatric electrophysiology services and prolonged rhythm monitoring is uneven.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the clinical spectrum of pediatric arrhythmias, identify independent risk factors, and assess treatment effectiveness and safety in a multicenter cohort from Xinjiang.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective multicenter study included children (\u226418 years) diagnosed with arrhythmia by ECG and\/or 24-hour Holter monitoring in six prefecture-level hospitals in Xinjiang (January 2019 to December 2024). A 1:1 age- and sex-matched healthy cohort served as controls. Candidate factors were screened by univariable chi-square tests and entered into multivariable binary logistic regression; results are reported as ORs with 95% CIs. Management was categorized as regular follow-up, pharmacotherapy, or radiofrequency catheter ablation, with effectiveness assessed using standardized follow-up criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We enrolled 232 children with arrhythmia (50.9% male), aged 1.2\u201318.0 years (mean 11.5\u2009\u00b1\u20093.6); 68.9% were \u22656 years. Supraventricular arrhythmias were most common (49.1%), and PSVT accounted for 35.3%. In multivariable analysis, congenital heart disease (OR 7.265, 95% CI 4.012\u201313.298), recent infection exposure (OR 6.452, 95% CI 3.605\u201311.521), and recurrent arrhythmia history (OR 8.216, 95% CI 4.458\u201315.169) were independent risk factors (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05), while age \u22656 years was not. Management included follow-up (65.5%), pharmacotherapy (25.0%), and ablation (9.5%). Ablation in 22 PSVT patients achieved 100% acute success with no recurrence over 6\u201312 months. Among 102 patients with complete effectiveness evaluation, the overall response rate was 88.2%; four mild adverse drug reactions were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This Xinjiang multicenter cohort reveals region-specific divergences from published data: higher PSVT (35.3%) and ventricular arrhythmia (24.1%) proportions, and markedly lower ablation utilization (9.5%) vs. tertiary centers in eastern China and internationally. Congenital heart disease, infection exposure, and recurrence history were independent risk factors (ORs 6.5\u20138.2). Key actionable findings: (1) targeted ECG screening for high-risk children; (2) maintenance of school-based screening for subclinical detection; and (3) effective stratified management with pharmacotherapy and selective ablation, with regional capacity building needed to close the interventional care gap.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1810814","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T06:03:28Z","timestamp":1780034608000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Spectrum, independent risk factors, and treatment outcomes of pediatric arrhythmias: a multicenter retrospective analysis in Xinjiang"],"prefix":"10.3389","volume":"14","author":[{"given":"Jinyong","family":"Pan","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Shihezi University","place":["Shihezi, Xinjiang, 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Shihezi University","place":["Shihezi, Xinjiang, China"]},{"name":"Department of Pediatrics , The First Affiliated Hospital of Shihezi University","place":["Shihezi, Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengling","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Shihezi University","place":["Shihezi, Xinjiang, China"]},{"name":"Department of Pediatrics , The First Affiliated Hospital of Shihezi University","place":["Shihezi, Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muqing","family":"Niu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Shihezi University","place":["Shihezi, Xinjiang, China"]},{"name":"Department of Pediatrics , The First Affiliated Hospital of Shihezi University","place":["Shihezi, Xinjiang, 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fourth Division Hospital of Xinjiang Construction Corps","place":["Kekedala, Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seventh Division Hospital of Xinjiang Construction Corps","place":["Huyanghe, Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, 10th Division Hospital of Xinjiang Construction Corps","place":["Beitun, Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Red Star Hospital, 13th Division","place":["Hami, Xinjiang, 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