{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:15:29Z","timestamp":1789992929434,"version":"4.0.1"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze clinical characteristics and risk factors of acute cutaneous graft-vs.-host disease (GVHD) in pediatric acute myeloid leukemia (AML) patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT), providing evidence for clinical risk stratification and individualized prophylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study included pediatric AML patients who underwent their first allo-HSCT at Hunan Children's Hospital between December 2019 and September 2025. Demographic, disease-related, donor-recipient matching, transplant procedure, and supportive care data were collected. The primary outcome was acute cutaneous GVHD within 100 days post-transplant. Univariate analysis identified potential risk factors, and multivariate logistic regression confirmed independent predictors, with sensitivity analysis verifying robustness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Acute cutaneous GVHD occurred in 27 pediatric patients (38.6%), including grade I (14.8%, 4\/27), II (59.3%, 16\/27), and III (25.9%, 7\/27) cases. Multivariate analysis showed HLA mismatch at \u22652\/10 alleles (OR\u2009=\u20094.26, 95%CI:1.68\u201310.82,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002), refractory\/relapsed disease pre-transplant (OR\u2009=\u20096.83, 95%CI:1.57\u201329.65,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.011), and myeloablative conditioning (MAC) (OR\u2009=\u20093.15, 95%CI:1.08\u20139.19,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.036) were independent risk factors. Sensitivity analysis confirmed result robustness, and subgroup analysis showed stronger associations with grade II-III aGVHD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Poor HLA matching, refractory\/relapsed disease pre-transplant, and MAC increase the risk of acute cutaneous GVHD in pediatric AML patients after allo-HSCT. The risk factors identified in this study are helpful for identifying high-risk pediatric AML patients before transplantation, providing a basis for implementing individualized GVHD prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1820755","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:38:42Z","timestamp":1784785122000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical characteristics and risk factors of acute cutaneous graft-vs.-host disease following allogeneic hematopoietic stem cell transplantation in pediatric acute myeloid leukemia: a single-center retrospective study"],"prefix":"10.3389","volume":"14","author":[{"given":"Shan","family":"He","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology, The Affiliated Children\u2019s Hospital of Xiangya School of Medicine, Central South University 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Children\u2019s Hospital)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, The Affiliated Children\u2019s Hospital of Xiangya School of Medicine, Central South University (Hunan Children\u2019s Hospital)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benshan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, The Affiliated Children\u2019s Hospital of Xiangya School of Medicine, Central South University (Hunan Children\u2019s Hospital)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"503","DOI":"10.6004\/jnccn.2023.0025","article-title":"Acute myeloid leukemia, version 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