{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:03:52Z","timestamp":1777637032551,"version":"3.51.4"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Ineffective erythropoiesis resulting from vitamin B12 deficiency leads to hemolysis. The breakdown of erythrocytes increases plasma bilirubin levels, which can cause jaundice in newborns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This descriptive cross-sectional study was conducted at the Department of Pediatric Hematology, Antalya Training and Research Hospital. In total, 103 infants with prolonged neonatal jaundice due to vitamin B12 deficiency, defined as a serum level below 250\u2005ng\/L, were included. Participants were divided into two groups based on treatment type: sublingual methylcobalamin (Group 1,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200972) and intramuscular cyanocobalamin (Group 2,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean gestational ages were 38.36\u2009\u00b1\u20091.4 weeks in Group 1 and 38.87\u2009\u00b1\u20090.81 weeks in Group 2. The mean ages at diagnosis were 35.74\u2009\u00b1\u200913.17 days and 35.9\u2009\u00b1\u200911.73 days, respectively. The female-to-male ratios were 30:42 in Group 1 and 16:15 in Group 2. Mean serum vitamin B12 levels in Group 1 were 138.82\u2009\u00b1\u200950.09\u2005ng\/L before treatment, 656.86\u2009\u00b1\u2009333.16\u2005ng\/L at 1.5 months, and 394.08\u2009\u00b1\u2009169.94\u2005ng\/L at 3 months following sublingual methylcobalamin therapy. In Group 2, the mean levels were 165.71\u2009\u00b1\u200956.07\u2005ng\/L before treatment, 502.9\u2009\u00b1\u2009196.07\u2005ng\/L at 1.5 months, and 345.77\u2009\u00b1\u2009115.42\u2005ng\/L at 3 months after intramuscular cyanocobalamin administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitamin B12 deficiency may be associated with prolonged jaundice in neonates. Early diagnosis of vitamin B12 deficiency enables timely initiation of sublingual methylcobalamin, a non-invasive and effective treatment option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1822723","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:00:52Z","timestamp":1777442452000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sublingual methylcobalamin treatment in infants with prolonged jaundice due to vitamin B12 deficiency"],"prefix":"10.3389","volume":"14","author":[{"given":"Sultan","family":"Aydin","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Antalya Training and Research Hospital","place":["Antalya, T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse","family":"Oz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, 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