{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T06:01:50Z","timestamp":1785132110846,"version":"3.55.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to explore the recurrence rate and risk factors for recurrence after antiseizure medications withdrawal in children with epilepsy through a meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Databases were searched up to May 8, 2025. Two reviewers independently screened the literature, extracted data, and assessed study quality. A meta-analysis was performed using Stata 15.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nineteen studies involving 3,226 children were included. The pooled recurrence rate was 28% (95% CI: 23%\u201333%). Risk factors included female gender, focal seizure, history of febrile seizures, delayed development\/intellectual disability, symptomatic etiology, abnormal electroencephalogram (EEG) after withdrawal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Multiple factors increase recurrence risk after antiseizure medications withdrawal in children, supporting individualized clinical decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1827056","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:41:03Z","timestamp":1785130863000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrence rate and risk factors of recurrence after antiseizure medications withdrawal in children with epilepsy: a meta-analysis"],"prefix":"10.3389","volume":"14","author":[{"given":"Hechengyue","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Neurology, West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University","place":["Chengdu, Sichuan, 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