{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:51:39Z","timestamp":1781679099008,"version":"3.54.5"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"\n Background<\/jats:title>\n We report a rare case of sodium valproate (VPA)-induced reversible myelodysplastic syndrome (MDS) in an Asian child with epilepsy, thus expanding the recognition of VPA-associated hematological toxicity. Although VPA has been widely used, the reversibility of MDS as a complication remains underreported, particularly in pediatric populations.<\/jats:p>\n <\/jats:sec>\n \n Case summary<\/jats:title>\n \n A 9-year-old boy with epilepsy developed pancytopenia (hemoglobin level: 77\u2005g\/L, platelet count: 83\u2009\u00d7\u200910\n 9<\/jats:sup>\n \/L) and bone marrow-confirmed MDS after 6\u2005months of VPA therapy. Following a reduction in VPA dose to 250\u2005mg\/day with adjunctive lacosamide, hematological parameters normalized within 3\u2005months, and a repeat bone marrow examination revealed resolution of dysplastic features. Seizure control was maintained without relapse. This case highlights the dose-dependent nature of VPA-induced MDS and demonstrates its reversibility upon therapeutic intervention.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The reversibility of VPA-induced MDS following dose adjustment underscores the importance of vigilant hematological monitoring in children.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fped.2026.1828816","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:52:20Z","timestamp":1781675540000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Reversible myelodysplastic syndrome secondary to sodium valproate in an epileptic child"],"prefix":"10.3389","volume":"14","author":[{"given":"Hongyu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, WCSUH-Tianfu, Sichuan Provincial Children\u2019s Hospital","place":["Meishan, China"]},{"name":"Department of Nursing, West China Second University Hospital, Sichuan University","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, WCSUH-Tianfu, Sichuan Provincial Children\u2019s Hospital","place":["Meishan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ye","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University","place":["Chengdu, China"]},{"name":"Department of Laboratory Medicine, West China Second University Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University","place":["Chengdu, China"]},{"name":"Department of Medical Genetics, West China Second University Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1542\/pir.2019-0134","article-title":"Seizures in children","volume":"41","author":"Fine","year":"2020","journal-title":"Pediatr Rev"},{"key":"B2","first-page":"37","article-title":"Short-term side effects of low dose valproate monotherapy in epileptic children: a prospective study","volume":"13","author":"Nasr Esfahani","year":"2019","journal-title":"Iran J Child 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