{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T06:17:52Z","timestamp":1778221072426,"version":"3.51.4"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To develop and validate a nomogram integrating chest computed tomography (CT) features and serum biomarkers for predicting the mutation status of macrolide resistance genes in pediatric Mycoplasma pneumoniae pneumonia (MPP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study enrolled children diagnosed with MPP, genetically stratified into macrolide-resistant (MRMP) and macrolide-sensitive (MSMP) groups based on 23S rRNA gene mutations (A2063G\/A2064G). Clinical data, chest CT scans obtained within 48\u2005h of admission, and serum biomarker levels (including C-reactive protein [CRP], procalcitonin [PCT], interleukin-6 [IL-6], D-dimer, neutrophil-to-lymphocyte ratio [NLR], and lactate dehydrogenase to albumin ratio [LAR]) measured within 24\u2005h of admission prior to antibiotic therapy were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to the MSMP group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009283), the MRMP group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009145) had longer fever duration (5.91 vs. 4.85 days) and hospital stay (8.77 vs. 7.32 days), higher rates of shortness of breath (35.86% vs. 24.38%) and oxygen requirement (25.52% vs. 13.78%), elevated serum levels of CRP (39.16 vs. 31.74\u2005mg\/L), D-dimer (1.51 vs. 1.32\u2005mg\/L FEU), NLR (6.15 vs. 5.22), PCT (0.55 vs. 0.35\u2005ng\/mL), IL-6 (28.86 vs. 21.35 pg\/mL), and LAR (9.19 vs. 8.42), and more frequent CT findings of lobar consolidation (68.28% vs. 45.23%), bilateral involvement (66.21% vs. 51.59%), pleural effusion (32.41% vs. 14.49%), and higher total severity score (9.22 vs. 7.88). The nomogram based on these independent predictors showed excellent discrimination with an area under the curve of 0.869.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A nomogram combining CT imaging characteristics and serum biomarkers predicted mutation status of macrolide resistance genes in pediatric MPP, potentially aiding early clinical decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1828908","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:55:20Z","timestamp":1778219720000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Construction of a nomogram combining CT and serum markers for predicting macrolide resistance gene mutation status in pediatric Mycoplasma pneumoniae pneumonia"],"prefix":"10.3389","volume":"14","author":[{"given":"Xinhui","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, the First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University","place":["Lanzhou, Gansu Province, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, the First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University","place":["Lanzhou, Gansu Province, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, the First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University","place":["Lanzhou, Gansu Province, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jizu","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, the First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University","place":["Lanzhou, Gansu Province, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, the First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University","place":["Lanzhou, Gansu Province, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, the First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University","place":["Lanzhou, Gansu Province, 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