{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:04:37Z","timestamp":1789538677664,"version":"build-2803163510"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, accounting for approximately 80% of childhood acute leukemia cases. Despite substantial improvements in survival in high-income countries, outcomes in Indonesia remain suboptimal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study analyzed medical records of pediatric ALL patients treated at Dr. Mohammad Hoesin General Hospital, Palembang, from 2019 to 2023 to describe demographic, clinical, laboratory, and immunophenotypic characteristics and their association with overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most patients were aged 1\u201310 years, male, and had normal nutritional status, with leukocyte counts &amp;lt;50,000\/\u00b5L, thrombocytopenia, and no central nervous system involvement or mediastinal mass. B-lineage ALL predominated. Univariate survival analysis showed that age at diagnosis, nutritional status, mediastinal mass, leukocyte count, and risk stratification were significantly associated with overall survival, whereas immunophenotypic classification was not. Multivariate Cox regression identified age &amp;gt;10 years and poor nutritional status as independent predictors of poorer overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings underscore the importance of early diagnosis and nutritional optimization to improve overall survival in pediatric ALL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1830355","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:30:55Z","timestamp":1789536655000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical outcomes in pediatric acute lymphoblastic leukemia: a retrospective cohort study from a tertiary center in Indonesia"],"prefix":"10.3389","volume":"14","author":[{"given":"Dian Puspita","family":"Sari","sequence":"first","affiliation":[{"name":"Department of Oncology, Dr. Mohammad Hoesin General Hospital","place":["Palembang, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewi Rosariah","family":"Ayu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Dr. Mohammad Hoesin General Hospital","place":["Palembang, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M.","family":"Indra","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, Dr. Mohammad Hoesin General Hospital","place":["Palembang, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eny","family":"Rahmawati","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Dr. Mohammad Hoesin General Hospital","place":["Palembang, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"900","DOI":"10.21037\/tp-2025-24","article-title":"Immunophenotyping in diagnosing pediatric acute leukemia after setting up the first flow cytometry unit in mosul city in Iraq: an observational study of the project performed through a contribution from Japan","volume":"14","author":"Al-Badrani","year":"2025","journal-title":"Transl Pediatr"},{"key":"B2","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s41182-025-00760-2","article-title":"Clinical characteristics and outcomes of paediatric acute lymphoblastic leukaemia in a tertiary hospital in Tanzania: a single-centre observational study","volume":"53","author":"Shimizu","year":"2025","journal-title":"Trop Med Health"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e0322747","DOI":"10.1371\/journal.pone.0322747","article-title":"Clinical profile and treatment outcomes of acute lymphoblastic leukemia among children attending at the university of gondar comprehensive specialized hospital and tikur anbessa specialized hospital in Ethiopia","volume":"20","author":"Kassa","year":"2025","journal-title":"PLoS One"},{"key":"B4","year":"2024"},{"key":"B5","year":"2024"},{"key":"B6","doi-asserted-by":"publisher","first-page":"115","DOI":"10.33371\/ijoc.v14i4.818","article-title":"Update on diagnosis of childhood acute lymphoblastic leukemia (ALL) in Indonesia","volume":"14","author":"Perdana","year":"2020","journal-title":"Indonesian Journal of Cancer"},{"key":"B7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.52403\/ijhsr.20250322","article-title":"Immunophenotyping in acute leukemia at a central laboratory installation RSUP dr. 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