{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:12:53Z","timestamp":1779257573619,"version":"3.51.4"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In recent years, non-invasive high-frequency oscillatory ventilation (NHFOV) has been widely used in clinical practice for premature infants with respiratory distress. However, until now, the focus of all published studies has been on the effect of NHFOV on patient's respiratory system, and its impact on the neonatal cerebral hemodynamics has not been considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We monitored the hemodynamics of the anterior cerebral arteries of 10 premature infants who received NHFOV treatment because of respiratory distress and compared them with the cerebral hemodynamics of patients who received invasive high-frequency oscillatory ventilation (IHFOV), invasive conventional mechanical ventilation (IMV), nasal continuous positive airway pressure (NCPAP), and those who did not receive ventilator treatment at the same time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results of this study revealed that NHFOV can have serious adverse effects on the cerebral hemodynamics of infants and subsequently lead to brain damage. Most importantly, this adverse effect of NHFOV is even more severe than that caused by IHFOV and IMV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Given that NHFOV has a severely adverse effect on the cerebral hemodynamics of patients compared with other non-invasive ventilation modes, it does not have any distinct advantages; therefore, we believe that NHFOV should be used with caution in premature infants, especially those who are extremely premature.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1830897","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:49:02Z","timestamp":1779256142000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The adverse effects of non-invasive high-frequency oscillatory ventilation on the cerebral hemodynamics of premature infants: point-of-care brain ultrasound findings from a case-series study"],"prefix":"10.3389","volume":"14","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neonatology and NICU, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital","place":["Beijing, China"]},{"name":"Department of Neonatology and NICU, Beijing Chaoyang District Maternal and Child Healthcare Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neonatology and NICU, Beijing Chaoyang District Maternal and Child Healthcare Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neonatology and NICU, Beijing Chaoyang District Maternal and Child Healthcare Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1001\/jamapediatrics.2022.0710","article-title":"Noninvasive high- frequency oscillatory ventilation vs nasal continuous positive airway pressure vs nasal intermittent positive pressure ventilation as postextubation support for preterm neonates in China: a randomized clinical trial","volume":"176","author":"Zhu","year":"2022","journal-title":"JAMA Pediatr"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e2321644","DOI":"10.1001\/jamanetworkopen.2023.21644","article-title":"Effectiveness of nasal continuous positive airway pressure vs nasal intermittent positive pressure ventilation vs noninvasive high-frequency oscillatory ventilation as support after extubation of neonates born extremely preterm or with more severe respiratory failure: a secondary analysis of a randomized clinical trial","volume":"6","author":"Zhu","year":"2023","journal-title":"JAMA Netw Open"},{"key":"B3","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s00431-025-06041-8","article-title":"Non-invasive high- frequency oscillatory ventilation versus non-invasive intermittent mandatory ventilation as a rescue mode in preterm infants with respiratory distress on nasal CPAP-a randomized control trial","volume":"184","author":"Rachana","year":"2025","journal-title":"Eur J Pediatr"},{"key":"B4","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.chest.2019.01.014","article-title":"Nasal high-frequency oscillatory ventilation in preterm infants with respiratory distress syndrome and ARDS after extubation: a randomized controlled trial","volume":"155","author":"Chen","year":"2019","journal-title":"Chest"},{"key":"B5","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1002\/ppul.26244","article-title":"Noninvasive high-frequency oscillatory ventilation versus nasal intermittent positive pressure ventilation for preterm infants as an extubation support: a systematic review and meta-analysis","volume":"58","author":"Wang","year":"2023","journal-title":"Pediatr Pulmonol"},{"key":"B6","first-page":"149","article-title":"Prevention of hemorrhagic cerebral injury in newborn and premature infants subjected to mechanical ventilation","volume":"55","author":"Gianturco","year":"1989","journal-title":"Minerva Anestesiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.earlhumdev.2009.01.008","article-title":"Influence of ventilation mode on neonatal cerebral blood flow and volume","volume":"85","author":"Milan","year":"2009","journal-title":"Early Hum Dev"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1016\/j.chest.2024.02.005","article-title":"The roles of point-of-care lung ultrasound in saving the life of neonates with rapidly deteriorative critical lung diseases","volume":"166","author":"Liu","year":"2024","journal-title":"Chest"},{"key":"B9","doi-asserted-by":"publisher","first-page":"3624","DOI":"10.3390\/diagnostics13243624","article-title":"No critical ultrasound, no life: the value of point-of care critical ultrasound in the rescue of critically ill infants","volume":"13","author":"Liu","year":"2023","journal-title":"Diagnostics"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e323","DOI":"10.5812\/ijp.323","article-title":"The role of lung ultrasound in diagnosis of respiratory distress syndrome in newborn infants","volume":"25","author":"Liu","year":"2015","journal-title":"Iran J Pediatr"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1016\/j.chest.2015.12.024","article-title":"Lung ultrasonography to diagnose transient tachypnea of the newborn","volume":"149","author":"Liu","year":"2016","journal-title":"Chest"},{"key":"B12","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/ppul.26168","article-title":"Lung ultrasound to diagnose infectious pneumonia of newborns: a prospective multicenter study","volume":"58","author":"Ma","year":"2023","journal-title":"Pediatr Pulmonol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e58990","DOI":"10.3791\/58990","article-title":"Protocol and guidelines for point-of-care lung ultrasound in diagnosing neonatal pulmonary diseases based on international expert consensus","volume":"145","author":"Liu","year":"2019","journal-title":"J Vis Exp"},{"key":"B14","doi-asserted-by":"publisher","first-page":"700632","DOI":"10.3389\/fped.2021.700632","article-title":"Nasal high-frequency oscillatory ventilation vs. Nasal continuous positive airway pressure as therapy for postextubation respiratory failure in infants after congenital heart surgery","volume":"9","author":"Wu","year":"2021","journal-title":"Front Pediatr"},{"key":"B15","doi-asserted-by":"publisher","first-page":"865057","DOI":"10.3389\/fped.2022.865057","article-title":"The long-term outcomes of preterm infants receiving non-invasive high-frequency oscillatory ventilation","volume":"10","author":"Li","year":"2022","journal-title":"Front Pediatr"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1055\/a-2113-3284","article-title":"Carbon dioxide level between nasal high-frequency oscillatory ventilationand synchronized nasal intermittent positive pressure ventilation after extubation in neonates: a cross-over randomized controlled trial","volume":"41","author":"Baingam","year":"2024","journal-title":"Am J Perinatol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1017\/S0265021506002006","article-title":"Effects of sequential changes from conventional ventilation to high-frequency oscillatory ventilation at increasing mean airway pressures in an ovine model of combined lung and head injury","volume":"24","author":"O'Rourke","year":"2007","journal-title":"Eur J Anaesthesiol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1002\/ppul.25195","article-title":"Hemodynamic effects of high-frequency oscillatory ventilation in preterm neonates with respiratory distress syndrome","volume":"56","author":"Ayoub","year":"2021","journal-title":"Pediatr Pulmonol"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1830897\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:49:04Z","timestamp":1779256144000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1830897\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":18,"alternative-id":["10.3389\/fped.2026.1830897"],"URL":"https:\/\/doi.org\/10.3389\/fped.2026.1830897","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]},"article-number":"1830897"}}