{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:46:27Z","timestamp":1782279987827,"version":"3.54.5"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Psoriasis is a chronic, recurrent, inflammatory skin disorder closely associated with dysregulation of the immune microenvironment. Conventional systemic therapies often face limitations in children due to safety concerns, highlighting the urgent need for safer and effective treatment options. Natural products, characterized by their multi-target and multi-pathway actions along with relatively favorable safety profiles, as suggested primarily by adult and preclinical studies, have shown great potential in modulating the immune microenvironment. This review summarizes recent advances in the use of natural products\u2014including plant extracts, active components, and compound formulations\u2014in reshaping the immune microenvironment of psoriatic lesions by regulating T cell subsets, cytokine networks, innate immune cell functions, and skin barrier integrity. We explicitly distinguish between evidence derived from pediatric clinical studies, adult studies, and preclinical models. Furthermore, the article explores the implications of these findings for developing novel therapeutic strategies specifically tailored for pediatric psoriasis, addressing current challenges, and outlining future directions for translational research. By integrating these insights, this review aims to provide a comprehensive understanding of how natural products can contribute to safer and more effective immunomodulatory treatments in children with psoriasis.<\/jats:p>","DOI":"10.3389\/fped.2026.1834627","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:48:03Z","timestamp":1782276483000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The therapeutic potential of natural products for pediatric psoriasis: targeting the immune microenvironment"],"prefix":"10.3389","volume":"14","author":[{"given":"Zitong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuhan University","place":["Wuhan, China"]},{"name":"The Second Clinical College of Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuhan University","place":["Wuhan, China"]},{"name":"The Second Clinical College of Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuhan University","place":["Wuhan, China"]},{"name":"The Second Clinical College of Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuhan University","place":["Wuhan, China"]},{"name":"Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Department of Dermatology, Shenzhen Nanshan People's Hospital\/The 6th Affiliated Hospital of Shenzhen University Health Science Center","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"102593","DOI":"10.1016\/j.mtbio.2025.102593","article-title":"Simultaneous targeting of multiple etiological using a nanosized strategy for psoriasis management","volume":"35","author":"Jiang","year":"2025","journal-title":"Mater Today Bio"},{"key":"B2","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1684\/ejd.2016.2932","article-title":"Childhood psoriasis","volume":"26","author":"Mahe","year":"2016","journal-title":"Eur J Dermatol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000251595","article-title":"The natural history of psoriasis in 5,600 patients","volume":"148","author":"Farber","year":"1974","journal-title":"Dermatologica"},{"key":"B4","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1007\/s40257-017-0294-9","article-title":"Pediatric psoriasis","volume":"18","author":"Relvas","year":"2017","journal-title":"Am J Clin Dermatol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3390\/ijms19010179","article-title":"Scanning the immunopathogenesis of psoriasis","volume":"19","author":"Chiricozzi","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.det.2014.09.002","article-title":"The immunopathogenesis of psoriasis","volume":"33","author":"Kim","year":"2015","journal-title":"Dermatol Clin"},{"key":"B7","doi-asserted-by":"publisher","first-page":"11574","DOI":"10.3390\/ijms222111574","article-title":"Current concepts of psoriasis immunopathogenesis","volume":"22","author":"Vicic","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1365-2133.2004.06009.x","article-title":"Psoriasis: immunopathogenesis and evolving immunomodulators and systemic therapies; U.S. Experiences","volume":"151","author":"Kormeili","year":"2004","journal-title":"Br J Dermatol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"5518","DOI":"10.3390\/ijms23105518","article-title":"Overlapping features of psoriasis and atopic dermatitis: from genetics to immunopathogenesis to phenotypes","volume":"23","author":"Tsai","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00281-015-0539-8","article-title":"Update on psoriasis immunopathogenesis and targeted immunotherapy","volume":"38","author":"Mahil","year":"2016","journal-title":"Semin Immunopathol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.clindermatol.2007.08.012","article-title":"Immunopathogenesis and role of T cells in psoriasis","volume":"25","author":"Ghoreschi","year":"2007","journal-title":"Clin Dermatol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s40257-025-00965-5","article-title":"The burden of pediatric psoriasis: a systematic review","volume":"26","author":"Yang","year":"2025","journal-title":"Am J Clin Dermatol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s40272-025-00715-4","article-title":"Long-Term efficacy and safety of secukinumab in children and adolescents with moderate-to-severe chronic plaque psoriasis: four-year results of a randomized, phase III, open-label trial","volume":"27","author":"Kingo","year":"2025","journal-title":"Paediatr Drugs"},{"key":"B14","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.det.2021.12.003","article-title":"Clinical decisions in pediatric psoriasis: a practical approach to systemic therapy","volume":"40","author":"Ornelas","year":"2022","journal-title":"Dermatol Clin"},{"key":"B15","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s40259-022-00569-z","article-title":"Biologic and small-molecule therapies for moderate-to-severe psoriasis: focus on psoriasis comorbidities","volume":"37","author":"Jiang","year":"2023","journal-title":"BioDrugs"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.3390\/molecules27061953","article-title":"Relationship between immune cells, depression, stress, and psoriasis: could the use of natural products be helpful?","volume":"27","author":"Alesci","year":"2022","journal-title":"Molecules"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1007\/s00210-024-03528-3","article-title":"Emerging insights into the role of natural products and miRNAs in psoriasis: from pathophysiology to precision medicine","volume":"398","author":"Mohammed","year":"2025","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.2174\/0115680266277952240223120435","article-title":"Immunomodulatory plant natural products as therapeutics against inflammatory skin diseases","volume":"24","author":"Kumar","year":"2024","journal-title":"Curr Top Med Chem"},{"key":"B19","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1515\/znc-2024-0153","article-title":"Phyto-pharmaceuticals as a safe and potential alternative in management of psoriasis: a review","volume":"80","author":"Patel","year":"2025","journal-title":"Z Naturforsch C J Biosci"},{"key":"B20","doi-asserted-by":"publisher","first-page":"6016","DOI":"10.3390\/molecules25246016","article-title":"Present Status and future trends of natural-derived compounds targeting T helper (th) 17 and microsomal prostaglandin E synthase-1 (mPGES-1) as alternative therapies for autoimmune and inflammatory-based diseases","volume":"25","author":"Saviano","year":"2020","journal-title":"Molecules"},{"key":"B21","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1039\/d5np00074b","article-title":"Natural products modulating interleukin-mediated pathways for anti-allergic and immunomodulatory effects","volume":"43","author":"Shah","year":"2026","journal-title":"Nat Prod Rep"},{"key":"B22","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3390\/md22090405","article-title":"Marine microorganism molecules as potential anti-inflammatory therapeutics","volume":"22","author":"Lasalo","year":"2024","journal-title":"Mar Drugs"},{"key":"B23","doi-asserted-by":"publisher","first-page":"629","DOI":"10.3390\/md21120629","article-title":"Polar lipids of marine microalgae nannochloropsis oceanica and chlorococcum amblystomatis mitigate the LPS-induced pro-inflammatory response in macrophages","volume":"21","author":"Conde","year":"2023","journal-title":"Mar Drugs"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1742455","DOI":"10.3389\/ffunb.2025.1742455","article-title":"Edible mushrooms as emerging biofactories for natural therapeutics and oral biopharmaceutical delivery","volume":"6","author":"Wang","year":"2025","journal-title":"Front Fungal Biol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.jep.2015.08.050","article-title":"Indigo naturalis and its component tryptanthrin exert anti-angiogenic effect by arresting cell cycle and inhibiting akt and FAK signaling in human vascular endothelial cells","volume":"174","author":"Chang","year":"2015","journal-title":"J Ethnopharmacol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1038\/s41598-023-30227-5","article-title":"Protective effect of anoectochilus burmannicus extracts and its active compound, kinsenoside on adipocyte differentiation induced by benzyl butyl phthalate and bisphenol A","volume":"13","author":"Buacheen","year":"2023","journal-title":"Sci Rep"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e2350","DOI":"10.1038\/cddis.2016.255","article-title":"Kinsenoside screening with a microfluidic chip attenuates gouty arthritis through inactivating NF-\u03baB signaling in macrophages and protecting endothelial cells","volume":"7","author":"Han","year":"2016","journal-title":"Cell Death Dis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41419-025-07358-w","article-title":"S1PR3-driven positive feedback loop sustains STAT3 activation and keratinocyte hyperproliferation in psoriasis","volume":"16","author":"Lian","year":"2025","journal-title":"Cell Death Dis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.3390\/cells10102636","article-title":"PI3Kdelta Sustains keratinocyte hyperproliferation and epithelial inflammation: implications for a topically druggable target in psoriasis","volume":"10","author":"Mercurio","year":"2021","journal-title":"Cells"},{"key":"B30","doi-asserted-by":"publisher","first-page":"106689","DOI":"10.1016\/j.intimp.2020.106689","article-title":"Hypoxia-inducible factor-1: a potential pharmacological target to manage psoriasis","volume":"86","author":"Zhu","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"120607","DOI":"10.1016\/j.jep.2025.120607","article-title":"Dictamnine inhibited keratinocyte hyperproliferation and alleviated psoriasis-like dermatitis via blocking HIF1A-mediated ferroptotic pathway","volume":"355","author":"Wang","year":"2026","journal-title":"J Ethnopharmacol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"903160","DOI":"10.3389\/fphar.2022.903160","article-title":"Efficacy and safety of curcumin in psoriasis: preclinical and clinical evidence and possible mechanisms","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Pharmacol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1728162","DOI":"10.3389\/fmed.2026.1728162","article-title":"Tripterygium glycosides: recent advances in mechanisms, therapeutic applications, and safety optimization","volume":"13","author":"Jin","year":"2026","journal-title":"Front Med (Lausanne"},{"key":"B34","doi-asserted-by":"publisher","first-page":"5777","DOI":"10.1007\/s10787-025-01954-0","article-title":"Natural products and nutraceuticals in the management of chronic inflammatory diseases: efficacy, mechanisms, and comparative insights","volume":"33","author":"Rao","year":"2025","journal-title":"Inflammopharmacology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"796","DOI":"10.3390\/jcm14030796","article-title":"Managing the overlap: therapeutic approaches in patients with concomitant psoriasis and atopic dermatitis-A case series","volume":"14","author":"de Felici Del Giudice","year":"2025","journal-title":"J Clin Med"},{"key":"B36","doi-asserted-by":"publisher","first-page":"4191","DOI":"10.1007\/s10787-025-01852-5","article-title":"Berberine as a natural immunomodulator of B lymphocytes","volume":"33","author":"Mohammadian Haftcheshmeh","year":"2025","journal-title":"Inflammopharmacology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"156486","DOI":"10.1016\/j.phymed.2025.156486","article-title":"Apigenin suppresses keratinocyte hyperproliferation and inflammation in psoriasis by inhibiting CDK2\/E2F2 pathway","volume":"144","author":"Alimujiang","year":"2025","journal-title":"Phytomedicine"},{"key":"B38","doi-asserted-by":"publisher","first-page":"22","DOI":"10.15586\/aei.v52i6.1157","article-title":"Gypenosides alleviates HaCaT keratinocyte hyperproliferation and ameliorates imiquimod-induced psoriasis in mice","volume":"52","author":"Liu","year":"2024","journal-title":"Allergol Immunopathol (Madr)"},{"key":"B39","doi-asserted-by":"publisher","first-page":"167879","DOI":"10.1016\/j.bbadis.2025.167879","article-title":"Quercetin induces keratinocytes apoptosis via triple inhibition of notch, PI3K\/AKT signaling and Glut1 in the treatment of psoriasis","volume":"1871","author":"Chen","year":"2025","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.3390\/ijms22062979","article-title":"Psoriasis: pathogenesis, comorbidities, and therapy updated","volume":"22","author":"Kanda","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B41","doi-asserted-by":"publisher","first-page":"6068","DOI":"10.3390\/ijms25116068","article-title":"Natural product-derived compounds targeting keratinocytes and molecular pathways in psoriasis therapeutics","volume":"25","author":"Lee","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B42","doi-asserted-by":"publisher","first-page":"3969","DOI":"10.1002\/ptr.7546","article-title":"Potential mechanism of oral baicalin treating psoriasis via suppressing wnt signaling pathway and inhibiting Th17\/IL-17 axis by activating PPAR\u03b3","volume":"36","author":"Chen","year":"2022","journal-title":"Phytother Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cbi.2017.04.020","article-title":"Investigating the potential of oxymatrine as a psoriasis therapy","volume":"271","author":"Chen","year":"2017","journal-title":"Chem Biol Interact"},{"key":"B44","doi-asserted-by":"publisher","first-page":"941071","DOI":"10.3389\/fimmu.2022.941071","article-title":"Dendritic cells and macrophages in the pathogenesis of psoriasis","volume":"13","author":"Kamata","year":"2022","journal-title":"Front Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"6718","DOI":"10.1038\/s41467-024-50993-8","article-title":"Skin hepcidin initiates psoriasiform skin inflammation via Fe-driven hyperproliferation and neutrophil recruitment","volume":"15","author":"Abboud","year":"2024","journal-title":"Nat Commun"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1136\/annrheumdis-2022-222229","article-title":"Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease","volume":"81","author":"Mellor","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"B47","doi-asserted-by":"publisher","first-page":"113449","DOI":"10.1016\/j.celrep.2023.113449","article-title":"Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis","volume":"42","author":"Hao","year":"2023","journal-title":"Cell Rep"},{"key":"B48","doi-asserted-by":"publisher","first-page":"116746","DOI":"10.1016\/j.jep.2023.116746","article-title":"Centella asiatica alleviates psoriasis through JAK\/STAT3-mediated inflammation: an in vitro and in vivo study","volume":"317","author":"Lin","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.3390\/antiox10122014","article-title":"Flavonoids present in propolis in the battle against photoaging and psoriasis","volume":"10","author":"Rivera-Ya\u00f1ez","year":"2021","journal-title":"Antioxidants"},{"key":"B50","doi-asserted-by":"publisher","first-page":"850967","DOI":"10.3389\/fphar.2022.850967","article-title":"ANGPTL4 Regulates psoriasis via modulating hyperproliferation and inflammation of keratinocytes","volume":"13","author":"Zuo","year":"2022","journal-title":"Front Pharmacol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1007\/s12016-024-08995-3","article-title":"Atopic dermatitis and psoriasis: similarities and differences in metabolism and microbiome","volume":"66","author":"Chen","year":"2024","journal-title":"Clin Rev Allergy Immunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1111\/jdv.19088","article-title":"Lysophosphatidylcholine facilitates the pathogenesis of psoriasis through activating keratinocytes and T cells differentiation via glycolysis","volume":"37","author":"Liu","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"121201","DOI":"10.1016\/j.lfs.2022.121201","article-title":"LPA\/LPAR1 signaling induces PGAM1 expression via AKT\/mTOR\/HIF-1\u03b1 pathway and increases aerobic glycolysis, contributing to keratinocyte proliferation","volume":"311","author":"Kim","year":"2022","journal-title":"Life Sci"},{"key":"B54","doi-asserted-by":"publisher","first-page":"5424","DOI":"10.3390\/ijms20215424","article-title":"Aryl hydrocarbon receptor in atopic dermatitis and psoriasis","volume":"20","author":"Furue","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B55","doi-asserted-by":"publisher","first-page":"109212","DOI":"10.1016\/j.clim.2022.109212","article-title":"Lipidomic profiling reveals metabolic signatures in psoriatic skin lesions","volume":"246","author":"Liu","year":"2023","journal-title":"Clin Immunol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"14872","DOI":"10.3390\/ijms241914872","article-title":"Crosstalk between Serum and skin sphingolipids in psoriasis","volume":"24","author":"Matwiejuk","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B57","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s12964-023-01381-0","article-title":"Triggers for the onset and recurrence of psoriasis: a review and update","volume":"22","author":"Liu","year":"2024","journal-title":"Cell Commun Signal"},{"key":"B58","doi-asserted-by":"publisher","first-page":"adv00407","DOI":"10.2340\/00015555-3766","article-title":"Metabolomic analysis of skin biopsies from patients with atopic dermatitis reveals hallmarks of inflammation, disrupted barrier function and oxidative stress","volume":"101","author":"Ilves","year":"2021","journal-title":". Acta Derm Venereol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1080\/13510002.2019.1658377","article-title":"Salidroside inhibits MAPK, NF-\u03baB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation","volume":"24","author":"Xu","year":"2019","journal-title":"Redox Rep"},{"key":"B60","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3109\/10715762.2016.1162301","article-title":"Oxidative stress in psoriasis and potential therapeutic use of antioxidants","volume":"50","author":"Lin","year":"2016","journal-title":"Free Radic Res"},{"key":"B61","doi-asserted-by":"publisher","first-page":"2249834","DOI":"10.1155\/2022\/2249834","article-title":"Psoriasis between autoimmunity and oxidative stress: changes induced by different therapeutic approaches","volume":"2022","author":"Medovic","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1016\/j.apsb.2024.12.020","article-title":"Topical adhesive spatio-temporal nanosystem co-delivering chlorin e6 and HMGB1 inhibitor glycyrrhizic acid for in situ psoriasis chemo-phototherapy","volume":"15","author":"Su","year":"2025","journal-title":"Acta Pharm Sin B"},{"key":"B63","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1111\/jcmm.17635","article-title":"Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: a review","volume":"27","author":"Bandopadhyay","year":"2023","journal-title":"J Cell Mol Med"},{"key":"B64","doi-asserted-by":"publisher","first-page":"155524","DOI":"10.1016\/j.phymed.2024.155524","article-title":"Anti-psoriasis effect of 18beta-glycyrrhetinic acid by breaking CCL20\/CCR6 axis through its vital active group targeting GUSB\/ATF2 signaling","volume":"128","author":"Wei","year":"2024","journal-title":"Phytomedicine"},{"key":"B65","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.biopha.2017.08.123","article-title":"Glycyrrhizic acid: a promising carrier material for anticancer therapy","volume":"95","author":"Su","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"B66","doi-asserted-by":"publisher","first-page":"826","DOI":"10.2174\/1389557519666190119111125","article-title":"Research progress of glycyrrhizic acid on antiviral activity","volume":"19","author":"Sun","year":"2019","journal-title":"Mini Rev Med Chem"},{"key":"B67","doi-asserted-by":"publisher","first-page":"155494","DOI":"10.1016\/j.phymed.2024.155494","article-title":"Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation","volume":"127","author":"He","year":"2024","journal-title":"Phytomedicine"},{"key":"B68","doi-asserted-by":"publisher","first-page":"S105","DOI":"10.1016\/j.jid.2023.03.623","article-title":"616 TC cream is a novel botanical topical therapy for the treatment of psoriasis","volume":"143","author":"Yang","year":"2023","journal-title":"J Invest Dermatol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.3928\/00904481-20111209-08","article-title":"Management of pediatric psoriasis","volume":"41","author":"Bhutani","year":"2012","journal-title":"Pediatr Ann"},{"key":"B70","doi-asserted-by":"publisher","first-page":"742","DOI":"10.36849\/jdd.7531","article-title":"Diagnosis and management of pediatric psoriasis: an overview for pediatricians","volume":"22","author":"Hebert","year":"2023","journal-title":"J Drugs Dermatol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1111\/bjd.13235","article-title":"Safety and efficacy of calcipotriol plus betamethasone dipropionate gel in the treatment of scalp psoriasis in adolescents 12\u221217 years of age","volume":"171","author":"Gooderham","year":"2014","journal-title":"Br J Dermatol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1111\/jdv.12789","article-title":"Treatment of paediatric scalp psoriasis with calcipotriene\/betamethasone dipropionate scalp formulation: effectiveness, safety and influence on children\u2019s quality of life in daily practice","volume":"29","author":"Oostveen","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s40272-015-0137-1","article-title":"Psoriasis in children and adolescents: diagnosis, management and comorbidities","volume":"17","author":"Bronckers","year":"2015","journal-title":"Paediatr Drugs"},{"key":"B74","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1111\/j.1468-3083.2006.01562.x","article-title":"Cyclosporin A treatment in severe childhood psoriasis","volume":"20","author":"Pereira","year":"2006","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"e12571","DOI":"10.1111\/dth.12571","article-title":"Management of pediatric psoriasis with Acitretin: a review","volume":"31","author":"Subedi","year":"2018","journal-title":"Dermatol Ther"},{"key":"B76","doi-asserted-by":"publisher","first-page":"5405","DOI":"10.3390\/ijms21155405","article-title":"Nutrition and psoriasis","volume":"21","author":"Kanda","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B77","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.clindermatol.2021.08.021","article-title":"The skin microbiome and the gut-skin axis","volume":"39","author":"Sinha","year":"2021","journal-title":"Clin Dermatol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.3390\/biomedicines10051037","article-title":"Gut-Skin axis: unravelling the connection between the gut microbiome and psoriasis","volume":"10","author":"Thye","year":"2022","journal-title":"Biomedicines"},{"key":"B79","doi-asserted-by":"publisher","first-page":"11225","DOI":"10.3390\/ijms241311225","article-title":"Transforming psoriasis care: probiotics and prebiotics as novel therapeutic approaches","volume":"24","author":"Buha\u0219","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B80","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1159\/000232304","article-title":"Practice of phototherapy in the treatment of moderate-to-severe psoriasis","volume":"38","author":"Nguyen","year":"2009","journal-title":"Curr Probl Dermatol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1111\/exd.14938","article-title":"Artificial intelligence in psoriasis: where we are and where we are going","volume":"32","author":"Liu","year":"2023","journal-title":"Exp Dermatol"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1834627\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:48:08Z","timestamp":1782276488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1834627\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,24]]},"references-count":81,"alternative-id":["10.3389\/fped.2026.1834627"],"URL":"https:\/\/doi.org\/10.3389\/fped.2026.1834627","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,24]]},"article-number":"1834627"}}