{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:54:01Z","timestamp":1781589241501,"version":"3.54.5"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010814","name":"Anhui Provincial Department of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diagnosis of pediatric nasopharyngeal carcinoma (NPC) is frequently delayed due to its rarity and histologic mimicry of benign lymphoproliferative disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report two pediatric cases of NPC presenting with isolated cervical lymphadenopathy, initially misdiagnosed as Kimura disease and classical Hodgkin lymphoma, respectively. Both patients were treated with multimodal chemoradiotherapy and remain under follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These cases highlight the diagnostic challenges of pediatric NPC, particularly its mimicry of reactive or inflammatory conditions. Persistent cervical lymphadenopathy in children warrants early core or excisional biopsy, routine cytokeratin staining, and EBER\n                      <jats:italic>in-situ<\/jats:italic>\n                      hybridization to expedite diagnosis and optimize outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1843731","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:37:36Z","timestamp":1781588256000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Pediatric nasopharyngeal carcinoma masquerading as benign lymphadenopathy: diagnostic pitfalls in two cases"],"prefix":"10.3389","volume":"14","author":[{"given":"Yuhan","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University)","place":["Wuhu, Anhui, China"]},{"name":"Department of Pediatric Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University)","place":["Wuhu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Wannan Medical University","place":["Wuhu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiqin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Wannan Medical University","place":["Wuhu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Education, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University)","place":["Wuhu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University)","place":["Wuhu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University)","place":["Wuhu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s12105-022-01449-2","article-title":"Update from the 5th edition of the World Health Organization classification of head and neck tumors: oropharynx and nasopharynx","volume":"16","author":"Badoual","year":"2022","journal-title":"Head Neck Pathol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1097\/MPH.0000000000002848","article-title":"Nasopharyngeal carcinoma in children, current treatment approach","volume":"46","author":"Ben-Ami","year":"2024","journal-title":"J Pediatr Hematol Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1002\/lary.31939","article-title":"Global, regional, and national burden of nasopharyngeal carcinoma from 1990 to 2021","volume":"135","author":"Wu","year":"2025","journal-title":"Laryngoscope"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.3390\/cancers17132237","article-title":"Pediatric versus adult nasopharyngeal cancer in diffusion-weighted magnetic resonance imaging","volume":"17","author":"Crasnean","year":"2025","journal-title":"Cancers (Basel)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1200\/JCO.19.01276","article-title":"Treatment of childhood nasopharyngeal carcinoma with induction chemotherapy and concurrent chemoradiotherapy: results of the children\u2019s oncology group ARAR0331 study","volume":"37","author":"Rodriguez-Galindo","year":"2019","journal-title":"J Clin Oncol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.7150\/thno.82690","article-title":"Nasopharyngeal carcinoma ecology theory: cancer as multidimensional spatiotemporal \u201cunity of ecology and evolution\u201d. pathological ecosystem","volume":"13","author":"Luo","year":"2023","journal-title":". 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