{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:48:01Z","timestamp":1782362881042,"version":"3.54.5"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Maternal early-onset preeclampsia (EOPE) may affect gastrointestinal function in very preterm infants, but its independent association with feeding intolerance (FI) and in-hospital morbidities remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective 1:1 gestational age-matched cohort study included 87 very preterm infants (&amp;lt;32 weeks) exposed to EOPE and 87 controls born to normotensive mothers. The primary outcome was FI. The secondary outcomes included bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), late-onset sepsis (LOS), retinopathy of prematurity (ROP), parenteral nutrition-associated cholestasis (PNAC), extrauterine growth restriction (EUGR), and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EOPE-exposed infants exhibited a significantly higher incidence of FI (77.0% vs. 41.4%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001) and a prolonged time to full enteral feeding (13.0 vs. 9.5 days,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.017). Multivariable logistic regression identified EOPE as an independent factor associated with FI (OR=2.290, 95% CI: 1.061\u20134.944,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.035). Lower birth weight was also independently associated with an increased risk of FI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Maternal EOPE may be associated with an increased risk of FI in very preterm infants, underscoring the necessity for targeted feeding monitoring and nutritional support in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1847317","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:21:37Z","timestamp":1782361297000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Early-onset preeclampsia exposure and hospital outcomes of very preterm infants: a retrospective analysis of feeding intolerance and hospital morbidities"],"prefix":"10.3389","volume":"14","author":[{"given":"Xinyue","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Peking University Third Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Peking University Third Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Peking University Third Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongyan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Peking University Third Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"B1","first-page":"38940793","article-title":"Exploring the effects of Various early hospital feeding approaches on feeding tolerance and growth in premature infants","volume":"28","author":"Wu","year":"2024","journal-title":"Altern Ther Health Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e2021203","DOI":"10.1590\/1984-0462\/2023\/41\/2021203","article-title":"Impact of early-onset preeclampsia on feeding tolerance and growth of very low birth weight infants during hospitalization","volume":"41","author":"Pel\u00edcia","year":"2022","journal-title":"Rev Paul Pediatr"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e0007623","DOI":"10.1128\/spectrum.00076-23","article-title":"Alterations in the gut microbiome and metabolisms in pregnancies with fetal growth restriction","volume":"11","author":"Tao","year":"2023","journal-title":"Microbiol Spectr"},{"key":"B4","doi-asserted-by":"publisher","first-page":"20503121231175759","DOI":"10.1177\/20503121231175759","article-title":"Association between micronutrients, oxidative stress biomarkers and angiogenic growth mediators in early and late-onset preeclamptic Ghanaian women","volume":"11","author":"Anto","year":"2023","journal-title":"SAGE Open Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s43032-024-01674-w","article-title":"Comparison of characteristics between early-onset and late-onset severe preeclampsia: a retrospective cohort study from a tertiary hospital in China","volume":"32","author":"Li","year":"2025","journal-title":"Reprod Sci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"l2381","DOI":"10.1136\/bmj.l2381","article-title":"Pre-eclampsia: pathophysiology and clinical implications","volume":"366","author":"Burton","year":"2019","journal-title":"Br Med J"},{"key":"B7","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1080\/01443615.2019.1706160","article-title":"Factors contributing to favourable neonatal outcomes in early-onset severe preeclampsia","volume":"41","author":"Sato","year":"2021","journal-title":"J Obstet Gynaecol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.preghy.2018.11.001","article-title":"Preeclampsia and risk of developing bronchopulmonary dysplasia in very preterm neonates","volume":"15","author":"Wilmink","year":"2019","journal-title":"Pregnancy Hypertens"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1111\/1471-0528.16683","article-title":"Pre-eclampsia and long-term health outcomes for mother and infant: an umbrella review","volume":"128","author":"Pittara","year":"2021","journal-title":"BJOG"},{"key":"B10","doi-asserted-by":"publisher","first-page":"844460","DOI":"10.3389\/fped.2022.844460","article-title":"Status and influencing factors of parenteral nutrition practice for late preterm infants in China","volume":"10","author":"Quan","year":"2022","journal-title":"Front. Pediatr"},{"key":"B11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/1471-2431-13-59","article-title":"A systematic review and meta-analysis to revise the fenton growth chart for preterm infants","volume":"13","author":"Fenton","year":"2013","journal-title":"BMC Pediatr"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1370361","DOI":"10.3389\/fped.2024.1370361","article-title":"Feeding intolerance scoring system in very preterm and very low birth weight infants using clinical and ultrasound findings","volume":"12","author":"Ifran","year":"2024","journal-title":"Front. Pediatr"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1164\/ajrccm.163.7.2011060","article-title":"Bronchopulmonary dysplasia","volume":"163","author":"Jobe","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","article-title":"Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging","volume":"187","author":"Bell","year":"1978","journal-title":"Ann Surg"},{"key":"B15","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm","volume":"92","author":"Papile","year":"1978","journal-title":"J Pediatr"},{"key":"B16","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1542\/peds.109.1.34","article-title":"Epidemiological, clinical, and microbiological characteristics of late-onset sepsis among very low birth weight infants in Israel: a national survey","volume":"109","author":"Makhoul","year":"2002","journal-title":"Pediatrics"},{"key":"B17","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1111\/dmcn.15468","article-title":"Retinopathy of prematurity","volume":"65","author":"Dammann","year":"2023","journal-title":"Dev Med Child Neurol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1136\/archdischild-2020-319108","article-title":"Parenteral lipid emulsions in the preterm infant: current issues and controversies","volume":"106","author":"Frazer","year":"2021","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"B19","doi-asserted-by":"publisher","first-page":"106153","DOI":"10.1016\/j.earlhumdev.2024.106153","article-title":"Metabolic bone disease in premature infants receiving parenteral nutrition: incidence, clinical, laboratory and nutritional profile","volume":"200","author":"Dos Santos","year":"2025","journal-title":"Early Hum Dev"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e2459557","DOI":"10.1001\/jamanetworkopen.2024.59557","article-title":"Meconium-Related obstruction and clinical outcomes in term and preterm infants","volume":"8","author":"Rook","year":"2025","journal-title":"JAMA Netw Open"},{"key":"B21","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1007\/s00101-024-01451-z","article-title":"Nosocomial pneumonia","volume":"73","author":"Ewig","year":"2024","journal-title":"Anaesthesiologie"},{"key":"B22","doi-asserted-by":"publisher","first-page":"4073","DOI":"10.1007\/s00431-024-05673-6","article-title":"Extrauterine growth restriction in very-low-birthweight infants: prevalence and concordance according to fenton, olsen, and INTERGROWTH-21st growth charts in a multicenter Spanish cohort","volume":"183","author":"Gonz\u00e1lez L\u00f3pez","year":"2024","journal-title":"Eur J Pediatr"},{"key":"B23","doi-asserted-by":"publisher","first-page":"S1186","DOI":"10.1016\/j.ajog.2020.10.052","article-title":"Preeclampsia has two phenotypes which require different treatment strategies","volume":"226","author":"Masini","year":"2021","journal-title":"Am J Obstet Gynecol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.7499\/j.issn.1008-8830.2404095","article-title":"Clinical features and risk factors of cholestasis in small for gestational age preterm infants","volume":"26","author":"Chen","year":"2024","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1055\/a-2490-3259","article-title":"Changes in liver shear wave elastography of preterm infants during hospitalization","volume":"42","author":"Kemmotsu","year":"2025","journal-title":"Am J Perinatol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1381193","DOI":"10.3389\/fped.2024.1381193","article-title":"Construction and validation of a risk prediction model for extrauterine growth restriction in preterm infants born at gestational age less than 34 weeks","volume":"12","author":"Xie","year":"2024","journal-title":"Front. Pediatr"},{"key":"B27","doi-asserted-by":"publisher","first-page":"452","DOI":"10.3390\/jcm11020452","article-title":"Early preeclampsia effect on preterm newborns outcome","volume":"11","author":"Matyas","year":"2022","journal-title":"J Clin Med"},{"key":"B28","doi-asserted-by":"publisher","first-page":"697690","DOI":"10.3389\/fped.2021.697690","article-title":"A good way to reduce screening for retinopathy of prematurity: development of the ROP model in a China preterm population","volume":"9","author":"Ding","year":"2021","journal-title":"Front. Pediatr"},{"key":"B29","doi-asserted-by":"publisher","first-page":"111","DOI":"10.23736\/S2724-5276.22.07019-7","article-title":"Maternal pre-eclampsia as a risk factor for developing bronchopulmonary dysplasia in neonates","volume":"77","author":"Vora","year":"2025","journal-title":"Minerva Pediatr (Torino)"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e60901","DOI":"10.7759\/cureus.60901","article-title":"Maternal preeclampsia and a preterm neonate with small bowel stenosis, Volvulus, and severe intrauterine growth restriction","volume":"16","author":"Babacheva","year":"2024","journal-title":"Cureus"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1055\/a-2183-5155","article-title":"Impact of size for gestational age on multivariate analysis of factors associated with necrotizing enterocolitis in preterm infants: retrospective cohort study","volume":"41","author":"S\u00e1nchez-Rosado","year":"2024","journal-title":"Am J Perinatol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3340\/jkns.2023.0020","article-title":"Perspectives: understanding the pathophysiology of intraventricular hemorrhage in preterm infants and considering of the future direction for treatment","volume":"66","author":"Park","year":"2023","journal-title":"J Korean Neurosurg Soc"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1847317\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:21:42Z","timestamp":1782361302000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1847317\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":32,"alternative-id":["10.3389\/fped.2026.1847317"],"URL":"https:\/\/doi.org\/10.3389\/fped.2026.1847317","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"article-number":"1847317"}}