{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:07:12Z","timestamp":1789020432880,"version":"build-2803163510"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epidural block is an effective labor analgesia method; adjunctive low-dose oxytocin may further influence uterine dynamics and clinical outcomes, but evidence in primiparas is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the association of epidural analgesia combined with low-dose oxytocin with pain intensity, labor duration, delivery mode, and immediate maternal\u2013neonatal outcomes in primiparous women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, 120 eligible primiparous women who delivered between January 2023 and January 2025 were classified by analgesia regimen into a combination group (epidural analgesia plus low-dose oxytocin) or a control group (epidural analgesia alone). We compared maternal demographics, VAS pain scores, durations of each labor stage, delivery mode, postpartum blood loss, maternal adverse events, and short-term neonatal outcomes (Apgar scores, NICU admission).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The combination group showed markedly lower VAS scores at 30\u2005min after analgesia, in active labor, and 2\u2005h postpartum (3.1\u2009\u00b1\u20090.9 vs. 7.0\u2009\u00b1\u20091.0; 3.5\u2009\u00b1\u20091.0 vs. 6.8\u2009\u00b1\u20091.1; 2.8\u2009\u00b1\u20090.8 vs. 6.5\u2009\u00b1\u20091.0; all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). First-stage, second-stage and total labor durations were shorter in the combination group (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05). Vaginal delivery rate was higher (86.7% vs. 60.0%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001) and emergency cesarean lower (10.0% vs. 30.0%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.006); combined treatment remained associated with vaginal birth (adjusted OR\u2009=\u20091.92, 95% CI\u2009=\u20091.10\u20133.34,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02). Common short-term maternal adverse events did not differ significantly between groups(\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;gt;\u20090.05), but hospital stay was shorter with the combination (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Epidural analgesia combined with low-dose oxytocin was associated with lower labor pain scores, shorter labor duration, and a higher rate of vaginal delivery in primiparous women, without a detectable increase in common short-term maternal or neonatal adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1850211","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:31:32Z","timestamp":1789018292000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of epidural block analgesia combined with Low-dose oxytocin with pain intensity and delivery outcomes in primiparous women"],"prefix":"10.3389","volume":"14","author":[{"given":"Yuhong","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ganxian District People\u2019s Hospital","place":["Ganzhou City, Jiangxi Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoxiang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ganxian District People\u2019s Hospital","place":["Ganzhou City, Jiangxi Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ganxian District People\u2019s Hospital","place":["Ganzhou City, Jiangxi Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanquan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ganxian District People\u2019s Hospital","place":["Ganzhou City, Jiangxi Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"CD000331","DOI":"10.1002\/14651858.CD000331.pub4","article-title":"Epidural versus non-epidural or no analgesia for pain management in labour","volume":"2018","author":"Anim-Somuah","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"B2","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/ijgo.14175","article-title":"Epidural analgesia in labor: a narrative review","volume":"159","author":"Halliday","year":"2022","journal-title":"Int J Gynaecol Obstet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.gofs.2020.09.015","article-title":"Normal childbirth: physiologic labor support and medical procedures. 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