{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:03:27Z","timestamp":1784873007378,"version":"3.55.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                      (MP) and respiratory syncytial virus (RSV) are major causes of pediatric pneumonia, and coinfection is increasingly recognized. However, the integrated laboratory characteristics and underlying host immune-inflammatory response patterns in children with MP\u2009+\u2009RSV coinfection remain unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this retrospective study, children with MP infection, RSV infection, and MP\u2009+\u2009RSV coinfection were analyzed. Hematological and biochemical parameters were compared using the Kruskal\u2013Wallis test with Dunn's\n                      <jats:italic>post hoc<\/jats:italic>\n                      analysis. Multivariate analysis (MANOVA, PCA), logistic regression with ROC analysis, and Spearman correlation were performed to evaluate global patterns and identify coinfection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Lymphocyte count differed significantly among groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001), showing a gradient pattern across MP, RSV, and MP\u2009+\u2009RSV. The coinfection group exhibited increased monocytes and significant alterations in liver, renal, and cardiac markers, indicating multi-organ involvement. Although MANOVA confirmed overall differences, PCA showed substantial overlap without a distinct cluster. A simplified model incorporating Lym, ALT, CK-MB, and Crea achieved moderate discrimination (AUC\u2009=\u20090.713). Correlation analysis revealed a denser immune\u2013organ interaction network in coinfection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MP\u2009+\u2009RSV coinfection is characterized by an integrated immune-inflammatory response with multi-organ involvement rather than a distinct phenotype. A simplified model based on routine laboratory indicators may facilitate early identification and clinical risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1888931","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:36:41Z","timestamp":1784871401000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Laboratory characteristics and immune-inflammatory profiles of Mycoplasma pneumoniae and respiratory syncytial virus coinfection in children: a retrospective study"],"prefix":"10.3389","volume":"14","author":[{"given":"Chao","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Changsha Economic Development Zone Hospital","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Laboratory 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