{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:52:13Z","timestamp":1791525133669,"version":"4.3.4"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Human parechovirus is a common pathogen causing respiratory and gastroenterological symptoms. Symptoms range from asymptomatic courses to rare encephalitis or sepsis-like symptoms. Studies regarding neurodevelopment after parechovirus encephalitis in infants are conflicting with indications of possible short or long term neurodevelopmental impairments. In this case report we describe an especially severe course of human parechovirus infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>A two-week-old infant presented with fever and developed seizures and apneic episodes after admission. Laboratory tests revealed leukopenia. A lumbar puncture revealed parechovirus via polymerase chain reaction (PCR). Recurrent seizures required extensive anticonvulsive therapy. Invasive ventilation for four days was necessary due to apneic episodes. Cranial magnetic resonance imaging (MRI) revealed white matter involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In neonates with a sepsis-like presentation and largely unremarkable laboratory and cerebrospinal fluid findings, parechovirus encephalitis is an important differential diagnosis. In this case, follow-up examinations showed age-appropriate neurodevelopment. However, owing to the severe clinical presentation and extensive neuroimaging abnormalities, long-term neurodevelopmental monitoring is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1889734","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:35:23Z","timestamp":1791524123000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: A severe case of human parechovirus encephalitis in a neonate"],"prefix":"10.3389","volume":"14","author":[{"given":"A. M.","family":"Grimm","sequence":"first","affiliation":[{"name":"University Hospital of Paediatrics \u2013 Elisabeth Children\u2019s Hospital, Department of Neonatology, Paediatric Intensive Care, Paediatric Cardiology, Paediatric Pneumology and Allergology, Klinikum Oldenburg A\u00f6R","place":["Oldenburg, Germany"]},{"name":"Carl von Ossietzky Universit\u00e4t Oldenburg, Faculty VI- Medicine and Health Sciences","place":["Oldenburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Heep","sequence":"additional","affiliation":[{"name":"University Hospital of Paediatrics \u2013 Elisabeth Children\u2019s Hospital, Department of Neonatology, Paediatric Intensive Care, Paediatric Cardiology, Paediatric Pneumology and Allergology, Klinikum Oldenburg A\u00f6R","place":["Oldenburg, Germany"]},{"name":"Carl von Ossietzky Universit\u00e4t Oldenburg, Faculty VI- Medicine and Health Sciences","place":["Oldenburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiaan Peter","family":"Sentner","sequence":"additional","affiliation":[{"name":"University Hospital of Paediatrics \u2013 Elisabeth Children\u2019s Hospital, Department of Neonatology, Paediatric Intensive Care, Paediatric Cardiology, Paediatric Pneumology and Allergology, Klinikum Oldenburg A\u00f6R","place":["Oldenburg, Germany"]},{"name":"Carl von Ossietzky Universit\u00e4t Oldenburg, Faculty VI- Medicine and Health Sciences","place":["Oldenburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. M.","family":"Fiedler","sequence":"additional","affiliation":[{"name":"University Hospital of Paediatrics \u2013 Elisabeth Children\u2019s Hospital, Department of Neonatology, Paediatric Intensive Care, Paediatric Cardiology, Paediatric Pneumology and Allergology, Klinikum Oldenburg A\u00f6R","place":["Oldenburg, Germany"]},{"name":"Carl von Ossietzky Universit\u00e4t Oldenburg, Faculty VI- Medicine and Health Sciences","place":["Oldenburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"piae069","DOI":"10.1093\/jpids\/piae069","article-title":"Enterovirus and parechovirus neurologic infections in children: clinical presentations and neuropathogenesis","volume":"14","author":"Freeman","year":"2025","journal-title":"J Pediatric Infect Dis Soc"},{"key":"B2","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/INF.0000000000001718","article-title":"Epidemiology of sepsis-like illness in young infants: major role of enterovirus and human parechovirus","volume":"37","author":"de Jong","year":"2018","journal-title":"Pediatr Infect Dis J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"S74","DOI":"10.1093\/ofid\/ofy209.177","article-title":"2569. 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