{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:27:27Z","timestamp":1787120847477,"version":"build-2736575974"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kawasaki disease (KD) is a systemic medium-vessel vasculitis of early childhood that, rarely, has been reported during the course of a pediatric burn. Because persistent fever, rash, and mucocutaneous changes overlap with the systemic inflammatory response to a burn wound, KD can go unrecognized, delaying the administration of intravenous immunoglobulin (IVIG), which reduces the risk of coronary sequelae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case description<\/jats:title>\n                    <jats:p>A previously healthy 1-year-old boy sustained a 6% total body surface area deep partial-thickness scald to the left lower limb. The wound healed with conservative dressing care and was almost completely re-epithelialized (&amp;gt;99%) by postburn day 10. On that same day, he developed an abrupt, persistent fever that peaked at 39.5\u00b0C\u201340\u00b0C and did not respond to empirical antibiotics. Over the next 48\u2005h, he developed bilateral non-purulent bulbar conjunctival injection, erythematous cracked lips with a strawberry tongue, a polymorphous trunk rash, palmoplantar erythema with hand induration, and non-suppurative cervical lymphadenopathy (largest node 20\u2009\u00d7\u200915\u2005mm). Investigations showed neutrophilic leukocytosis (WBC 16.22\u2009\u00d7\u200910\u2079\/L), a C-Reactive Protein (CRP) level of 42.65\u2005mg\/L, mild hyperbilirubinemia and transaminitis, and elevated levels of IL-6, soluble IL-2 receptor, and TNF-\u03b1. The platelet count was 456\u2009\u00d7\u200910\u2079\/L at admission, 384\u2009\u00d7\u200910\u2079\/L during the acute phase, and increased to 657\u2009\u00d7\u200910\u2079\/L during convalescence. Infectious and rheumatological differentials were excluded. The patient met all six principal criteria of the JCS\/JSCS 2020 guideline, leading to a diagnosis of complete KD. He received IVIG (2\u2005g\/kg) and oral aspirin (30\u2005mg\/kg\/day, tapered after defervescence). Fever resolved within 24\u2005h, followed by periungual desquamation. Transthoracic echocardiography showed a patent foramen ovale without coronary artery abnormalities, and repeat imaging at approximately 1 week and 1 month after onset confirmed normal coronary arteries with no evidence of aneurysms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case illustrates that KD can emerge as a burn wound re-epithelializes, at which point the reappearance of fever is easily misattributed to an intercurrent infection. Across the present case and 13 previously reported, primary-source-verified cases, burn-associated KD occurred in children aged 5 years or younger, usually presented within about 2 weeks of the burn, mostly followed modest burns, and responded promptly to IVIG, with acute coronary artery changes observed in a minority (three of 14) that regressed after treatment. Whether burn injury triggers KD or the two co-occur by chance cannot be determined from a single case; the practical message is that clinicians should re-examine all mucocutaneous surfaces and consider KD in any pediatric burn patient with unexplained persistent fever, so that IVIG is not delayed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1902593","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:45:41Z","timestamp":1787118341000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Kawasaki disease following a pediatric scald burn: a case report and literature review"],"prefix":"10.3389","volume":"14","author":[{"given":"Hanqin","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Burn Surgery, Taizhou School of Clinical Medicine, Nanjing Medical University","place":["Taizhou, Jiangsu, 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