{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:49:54Z","timestamp":1791355794670,"version":"4.3.1"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"\n Background<\/jats:title>\n Anthropometric assessment remains the cornerstone of the identification and classification of pediatric undernutrition, whereas the role of laboratory biomarkers is less well established.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate serum copeptin in children with undernutrition and to compare its discriminatory performance with that of serum albumin.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This single-center cross-sectional case-control study included children aged 1 month to 18 years with undernutrition and healthy controls recruited from the same clinical setting. Serum copeptin concentrations were measured by enzyme-linked immunosorbent assay. Receiver operating characteristic analysis and multivariable logistic regression were performed. Age-stratified and sensitivity analyses were also conducted.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 98 children were included: 44 with undernutrition and 54 healthy controls. Serum copeptin concentrations were significantly higher and serum albumin concentrations were significantly lower in children with undernutrition than in healthy controls (both\n p<\/jats:italic>\n \u2009&lt;\u20090.001). In ROC analysis, copeptin yielded an area under the curve of 0.729 (95% CI 0.622\u20130.835), whereas albumin yielded an area under the curve of 0.726 (95% CI 0.618\u20130.833), with no significant difference between the two ROC curves (DeLong\n p<\/jats:italic>\n \u2009=\u20090.977). In multivariable analysis adjusted for age and sex, both copeptin and albumin remained independently associated with undernutrition. A combined copeptin\u2013albumin model showed higher discrimination within the study sample.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Serum copeptin is elevated in children with undernutrition. Although it does not outperform albumin as a standalone biomarker, it may provide complementary information when interpreted alongside albumin.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fped.2026.1902840","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:53:46Z","timestamp":1791352426000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Copeptin and albumin in children with undernutrition"],"prefix":"10.3389","volume":"14","author":[{"given":"Halil U\u011fur","family":"Hatipo\u011flu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Hamidiye Faculty of Medicine, Istanbul Haseki Training and Research Hospital","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsen","family":"G\u00fcler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Hamidiye Faculty of Medicine, Istanbul Haseki Training and Research Hospital","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Elevli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Hamidiye Faculty of Medicine, Istanbul Haseki Training and Research Hospital","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"B1","volume-title":"Levels and Trends in Child Malnutrition: Key Findings of the 2025 Edition","year":"2025"},{"key":"B2","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1177\/0884533614557642","article-title":"Consensus statement of the academy of nutrition and dietetics\/American society for parenteral and enteral nutrition: indicators recommended for the identification and documentation of pediatric 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