{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:03:33Z","timestamp":1789625013526,"version":"build-2803163510"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018693","name":"HORIZON EUROPE Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Children, adolescents and young adults with cancer face severely reduced exercise tolerance while undergoing treatment, which places an additional burden on their health. The FORTEe research project, a European multicenter randomized clinical trial, investigates if a precision-based exercise program (PEx) can reduce cancer-related fatigue and maintain or improve a broad range of physical and psychosocial outcomes, thereby supporting its integration into standard paediatric oncology care from the start of cancer treatment. This methodological paper describes how the protocols were developed, applied in the field, and disseminated within the scientific community.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One year of consultation between the 10 clinical centers across the FORTEe consortium in Europe lead to the FORTEe precision-based exercise protocols (FORTEe-exprot). They include cardiorespiratory, resistance, flexibility, balance, and coordination training, tailored to age, functional status, and treatment intensity. Sessions are intended to be delivered 3\u20135 times\/week, 20\u201360\u2005minutes, in inpatient, outpatient, and home settings, with in-person or telehealth supervision. Safety considerations comprised individualized modifications, vital signs monitoring, and structured reporting of adverse events. Daily documentation of exercise type, intensity, duration, and individual perceived exertion informs ongoing prescription adjustments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A final version of the FORTEe-exprot was ready by March 2022, prior to the start of clinical trial recruitment. During their development, potential risks were carefully considered, including injury, staff experience, data quality, recruitment, and compliance. The FORTEe-exprot were designed to be inclusive, accommodating children with varying needs and ensuring applicability across different levels of expertise among exercise professionals and diverse clinical settings. The FORTEe-exprot printed handbooks were disseminated internally and externally via conferences and distribution of around 50 countries worldwide. They are freely downloadable from the FORTEe website and from Zenodo, an open research repository commonly used for EU-funded research projects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Effective implementation of PEx requires appropriately trained exercise professionals, risk-stratified prescription, daily documentation, and close interdisciplinary collaboration to ensure safe, individualized interventions aligned with each child's clinical status. Such multi-stakeholder collaboration constituted a key foundation of the FORTEe-exprot, highlighting their potential role in pediatric oncology care and their possible contribution to future evidence-based recommendations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1907775","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:31:00Z","timestamp":1789623060000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Precision-based exercise protocols for children with cancer: a methodological approach from the European FORTEe research project"],"prefix":"10.3389","volume":"14","author":[{"given":"Francesca","family":"Lanfranconi","sequence":"first","affiliation":[{"name":"Centro Maria Letizia Verga - Fondazione Monza e Brianza per il Bambino e la sua Mamma","place":["Monza, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Dreismickenbecker","sequence":"additional","affiliation":[{"name":"University Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center Mainz","place":["Mainz, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Zardo","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Istituto Nazionale dei Tumori, Pediatric Oncology Unit","place":["Milano, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Moriggi","sequence":"additional","affiliation":[{"name":"Centro Maria Letizia Verga - Fondazione Monza e Brianza per il Bambino e la sua Mamma","place":["Monza, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Villa","sequence":"additional","affiliation":[{"name":"Centro Maria Letizia Verga - Fondazione Monza e Brianza per il Bambino e la sua Mamma","place":["Monza, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Radaelli","sequence":"additional","affiliation":[{"name":"Centro Maria Letizia Verga - Fondazione Monza e Brianza per il Bambino e la sua Mamma","place":["Monza, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Corti","sequence":"additional","affiliation":[{"name":"Centro Maria Letizia Verga - Fondazione Monza e Brianza per il Bambino e la sua Mamma","place":["Monza, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Peli","sequence":"additional","affiliation":[{"name":"Centro Maria Letizia Verga - Fondazione Monza e Brianza per il Bambino e la sua Mamma","place":["Monza, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie A.","family":"Neu","sequence":"additional","affiliation":[{"name":"University Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center Mainz","place":["Mainz, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mareike","family":"Kuehn","sequence":"additional","affiliation":[{"name":"University Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center Mainz","place":["Mainz, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Wypyrsczyk","sequence":"additional","affiliation":[{"name":"University Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center Mainz","place":["Mainz, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Fiuza-Luces","sequence":"additional","affiliation":[{"name":"Hospital 12 de Octubre Research Institute, \u2018imas12\u201a, Physical Activity and Health Laboratory","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Lucia","sequence":"additional","affiliation":[{"name":"Department of Sports Sciences, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"G\u00f6tte","sequence":"additional","affiliation":[{"name":"University Hospital Essen, West German Cancer Center","place":["Essen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Kaj","family":"Fridh","sequence":"additional","affiliation":[{"name":"University Hospital Copenhagen, Rigshospitalet, Department of Pediatrics and Adolescent Medicine","place":["Copenhagen, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidija","family":"Kitanovski","sequence":"additional","affiliation":[{"name":"University Medical Center Ljubljana, Division of Pediatrics, Department of Haematooncology","place":["Ljubljana, Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Konda","sequence":"additional","affiliation":[{"name":"Forma 3D Ltd., Forma 3D","place":["Ljubljana, Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Marriott","sequence":"additional","affiliation":[{"name":"School of Sport, Nutrition and Allied Health Professions, Faculty of Health Science, and Technology, Oxford Brookes University","place":["Oxford, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolf","family":"Mongondry","sequence":"additional","affiliation":[{"name":"Centre de Lutte Contre le Cancer L\u00e9on B\u00e9rard, Prevention Cancer Environment Department","place":["Lyon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Spreafico","sequence":"additional","affiliation":[{"name":"Oncology Unit, IRCCS Istituto Giannina Gaslini","place":["Genova, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Wiskemann","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Working Group Exercise Oncology, a partnership between DKFZ and University Medical Center Heidelberg, Heidelberg University Hospital and National Center for Tumor Diseases","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Balduzzi","sequence":"additional","affiliation":[{"name":"Pediatric Department, Fondazione IRCCS San Gerardo dei Tintori and School of Medicine and Surgery, Milano-Bicocca University","place":["Monza, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Faber","sequence":"additional","affiliation":[{"name":"University Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center Mainz","place":["Mainz, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4591","DOI":"10.1210\/jcem.84.12.6205","article-title":"Degree of fatness after treatment for acute lymphoblastic leukemia in childhood","volume":"84","author":"Nysom","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"B2","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1002\/mpo.1084","article-title":"Motor nervous pathway function is impaired after treatment of childhood acute lymphoblastic leukemia: a study with motor evoked potentials","volume":"36","author":"Harila-Saari","year":"2001","journal-title":"Med Pediatr Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/sj.leu.2402078","article-title":"Bone mineral decrements in survivors of childhood acute lymphoblastic leukemia: frequency of occurrence and risk factors for their development","volume":"15","author":"Kaste","year":"2001","journal-title":"Leukemia"},{"key":"B4","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/mpo.2950240403","article-title":"Lung function and exercise capacity in childhood leukemia survivors","volume":"24","author":"Jenney","year":"1995","journal-title":"Med Pediatr Oncol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1016\/j.ejca.2007.04.015","article-title":"Long term survivors of childhood cancer: cure and care. The erice statement","volume":"43","author":"Haupt","year":"2007","journal-title":"Eur J Cancer"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1200\/JCO.2006.06.2539","article-title":"High body mass index increases the risk for osteonecrosis in children with acute lymphoblastic leukemia","volume":"25","author":"Niinim\u00e4ki","year":"2007","journal-title":"J Clin Oncol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"341","DOI":"10.2522\/ptj.20070108","article-title":"Relationships among severity of osteonecrosis, pain, range of motion, and functional mobility in children, adolescents, and young adults with acute lymphoblastic leukemia","volume":"88","author":"Marchese","year":"2008","journal-title":"Phys Ther"},{"key":"B8","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/pbc.21942","article-title":"A randomized trial investigating an exercise program to prevent reduction of bone mineral density and impairment of motor performance during treatment for childhood acute lymphoblastic leukemia","volume":"53","author":"Hartman","year":"2009","journal-title":"Pediatr. Blood Cancer"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1002\/pbc.22637","article-title":"Low anthracycline doses-induced cardiotoxicity in acute lymphoblastic leukemia long-term female survivors","volume":"55","author":"Amigoni","year":"2010","journal-title":"Pediatr Blood Cancer"},{"key":"B10","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1097\/MPH.0000000000000067","article-title":"Muscle strength, motor performance, cardiac and muscle biomarkers in detection of muscle side effects during and after acute lymphoblastic leukemia treatment in children","volume":"36","author":"Akyay","year":"2014","journal-title":"J Pediatr Hematol Oncol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1159\/000494809","article-title":"Skeletal morbidity in children and adolescents during and following cancer therapy","volume":"91","author":"Mostoufi-Moab","year":"2019","journal-title":"Horm Res Paediatr"},{"key":"B12","doi-asserted-by":"publisher","first-page":"12892","DOI":"10.1038\/s41598-020-69393-1","article-title":"Precision-based exercise as a new therapeutic option for children and adolescents with haematological malignancies","volume":"10","author":"Lanfranconi","year":"2020","journal-title":"Sci Rep"},{"key":"B13","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1055\/a-1073-8104","article-title":"Exercise interventions and cardiovascular health in childhood cancer: a meta-analysis","volume":"41","author":"Morales","year":"2020","journal-title":"Int J Sports Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e99282","DOI":"10.1371\/journal.pone.0099282","article-title":"Near infrared spectroscopy (NIRS) as a new non-invasive tool to detect oxidative skeletal muscle impairment in children survived to acute lymphoblastic leukaemia","volume":"9","author":"Lanfranconi","year":"2014","journal-title":"PLoS One"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.3109\/10428194.2014.944519","article-title":"Skeletal, neuromuscular and fitness impairments among children with newly diagnosed acute lymphoblastic leukemia","volume":"56","author":"Ness","year":"2015","journal-title":"Leuk Lymphoma"},{"key":"B16","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1080\/08880018.2016.1219796","article-title":"Muscle strength and quality of life in patients with childhood cancer at early phase of primary treatment","volume":"33","author":"Deisenroth","year":"2016","journal-title":"Pediatr Hematol Oncol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ejca.2018.07.006","article-title":"The survivorship passport for childhood cancer survivors","volume":"102","author":"Haupt","year":"2018","journal-title":"Eur J Cancer"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e13418","DOI":"10.1111\/ecc.13418","article-title":"Within 5-year off-chemotherapy: how the cardio-respiratory response to exercise is related to energy expenditure, fatigue, and adiposity in children with acute lymphoblastic leukaemia?","volume":"30","author":"Elnaggar","year":"2021","journal-title":"Eur J Cancer Care"},{"key":"B19","doi-asserted-by":"publisher","first-page":"5515","DOI":"10.1182\/blood-2007-10-117150","article-title":"Twenty-five-year follow-up among survivors of childhood acute lymphoblastic leukemia: a report from the childhood cancer survivor study","volume":"111","author":"Mody","year":"2008","journal-title":"Blood"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1001\/jama.2013.6296","article-title":"Clinical ascertainment of health outcomes among adults treated for childhood cancer","volume":"309","author":"Hudson","year":"2013","journal-title":"JAMA"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.3390\/cancers14051187","article-title":"The impact of a precision-based exercise intervention in childhood hematological malignancies evaluated by an adapted yo-yo intermittent recovery test","volume":"14","author":"Zardo","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/sj.leu.2403547","article-title":"Is physical fitness decreased in survivors of childhood leukemia? A systematic review","volume":"19","author":"Van Brussel","year":"2005","journal-title":"Leukemia"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e27286","DOI":"10.1002\/pbc.27286","article-title":"Influence of fitness on health status among survivors of acute lymphoblastic leukemia","volume":"65","author":"Wilson","year":"2018","journal-title":"Pediatr Blood Cancer"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1007\/s00520-021-06719-3","article-title":"Exercise reduces systemic immune inflammation index in childhood cancer patients","volume":"30","author":"Winker","year":"2022","journal-title":"Support Care Cancer"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1038\/leu.2011.84","article-title":"Dexamethasone versus prednisone for induction therapy in childhood acute lymphoblastic leukemia: a systematic review and meta-analysis","volume":"25","author":"Teuffel","year":"2011","journal-title":"Leukemia"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1038\/s41409-019-0535-z","article-title":"Psychophysical effects of an exercise therapy during pediatric stem cell transplantation: a randomized controlled trial","volume":"54","author":"Senn-Malashonak","year":"2019","journal-title":"Bone Marrow Transplant"},{"key":"B27","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1097\/PHM.0000000000000757","article-title":"Effects of exercise on immune function in pediatric solid tumors","volume":"96","author":"Fiuza-Luces","year":"2017","journal-title":"Am J Phys Med Rehabil"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1016\/j.pec.2018.07.008","article-title":"An integrated experiential training programme with coaching to promote physical activity, and reduce fatigue among children with cancer: a randomised controlled trial","volume":"101","author":"Lam","year":"2018","journal-title":"Patient Educ Couns"},{"key":"B29","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3389\/fped.2020.00243","article-title":"Benefits of exercise training for children and adolescents undergoing cancer treatment: results from the randomized controlled MUCKI trial","volume":"8","author":"St\u00f6ssel","year":"2020","journal-title":"Front Pediatr"},{"key":"B30","doi-asserted-by":"publisher","first-page":"833850","DOI":"10.3389\/fped.2022.833850","article-title":"Integrative neuromuscular training in adolescents and children treated for cancer (INTERACT): study protocol","volume":"10","author":"Schmidt-Andersen","year":"2022","journal-title":"Front Pediatr"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1186\/s12885-025-14489-y","article-title":"Get strong to fight childhood cancer - an exercise intervention for children and adolescents undergoing anti-cancer treatment (FORTEe): rationale and design of a randomized controlled exercise trial","volume":"25","author":"Neu","year":"2025","journal-title":"BMC Cancer"},{"key":"B32","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1519\/00124278-200702000-00031","article-title":"Early-phase adaptations to intrahospital training in strength and functional mobility of children with leukemia","volume":"21","author":"San Juan","year":"2007","journal-title":"J Strength Cond Res"},{"key":"B33","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1002\/cncr.24043","article-title":"Promoting physical activity in childhood cancer survivors","volume":"115","author":"Cox","year":"2009","journal-title":"Cancer"},{"key":"B34","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1177\/1534735416679515","article-title":"Influence of a moderate-intensity exercise program on NK cell immune recovery in pediatric patients after HSCT","volume":"16","author":"Chamorro-Vi\u00f1a","year":"2017","journal-title":"Integr Cancer Ther"},{"key":"B35","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1002\/pon.1484","article-title":"Development, feasibility and efficacy of a community-based exercise training program in pediatric cancer survivors","volume":"18","author":"Takken","year":"2009","journal-title":"Psychooncology"},{"key":"B36","first-page":"387","article-title":"Effects of a combined aerobic and strength training program in youth patients with acute lymphoblastic leukemia","volume":"11","author":"Perondi","year":"2012","journal-title":"J Sports Sci Med"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e28687","DOI":"10.1002\/pbc.28687","article-title":"Combined resistance and aerobic exercise intervention improves fitness, insulin resistance, and quality of life in survivors of childhood haemopoietic stem cell transplantation with total body irradiation","volume":"67","author":"Davis","year":"2020","journal-title":"Pediatr Blood Cancer"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1007\/s00520-017-4041-9","article-title":"Physical activity barriers, preferences, and beliefs in childhood cancer patients","volume":"26","author":"Ross","year":"2018","journal-title":"Support Care Cancer"},{"key":"B39","doi-asserted-by":"publisher","first-page":"834512","DOI":"10.3389\/fped.2022.834512","article-title":"Rehabilitation including structured active play for preschoolers with cancer (RePlay): study protocol for a randomized controlled trial","volume":"10","author":"Pouplier","year":"2022","journal-title":"Front Pediatr"},{"key":"B40","doi-asserted-by":"publisher","first-page":"102639","DOI":"10.1016\/j.ejon.2024.102639","article-title":"Rehabilitation including structured active play intervention for preschoolers with cancer during treatment: a RePlay qualitative study of parents\u2019 experiences","volume":"71","author":"Pouplier","year":"2024","journal-title":"Eur J Oncol Nurs"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1634626","DOI":"10.3389\/fonc.2025.1634626","article-title":"Telemedicine-based adapted physical activity programs for pediatric oncology patients in active oncological care: a feasibility study","volume":"15","author":"Peli","year":"2025","journal-title":"Front Oncol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1055\/s-2007-965571","article-title":"Benefits of intrahospital exercise training after pediatric bone marrow transplantation","volume":"29","author":"San Juan","year":"2008","journal-title":"Int J Sports Med"},{"key":"B43","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1055\/s-2007-964908","article-title":"Functional capacity of children with leukemia","volume":"29","author":"San Juan","year":"2008","journal-title":"Int J Sports Med"},{"key":"B44","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/jcsm.12042","article-title":"A framework for prescription in exercise-oncology research","volume":"6","author":"Sasso","year":"2015","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"B45","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMoa2502760","article-title":"Structured exercise after adjuvant chemotherapy for colon cancer (CHALLENGE)","volume":"393","author":"Courneya","year":"2025","journal-title":"N Engl J Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1249\/MSS.0000000000003795","article-title":"Physical activity and exercise intensity terminology: a joint American college of sports medicine (ACSM) expert statement and exercise and sport science Australia (ESSA) consensus statement","volume":"57","author":"Bishop","year":"2025","journal-title":"Med Sci Sports Exerc"},{"key":"B47","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1002\/1097-0142(19871001)60:7<1651::AID-CNCR2820600738>3.0.CO;2-J","article-title":"The measurement of performance in childhood cancer patients","volume":"60","author":"Lansky","year":"1987","journal-title":"Cancer"},{"key":"B48","first-page":"191","article-title":"Evaluation of chemotherapeutic agents","volume-title":"The Clinical Evaluation of Chemotherapeutic Agents in Cancer","author":"Karnofsky","year":"1949"},{"key":"B49","doi-asserted-by":"publisher","first-page":"627876","DOI":"10.3389\/fped.2021.627876","article-title":"Positive impact of organized physical exercise on quality of life and fatigue in pediatric oncology","volume":"9","author":"Spreafico","year":"2021","journal-title":"Front Pediatr"},{"key":"B50","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/s41585-021-00533-6","article-title":"Recommending exercise for children with a single kidney","volume":"19","author":"Spreafico","year":"2022","journal-title":"Nat Rev Urol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"982996","DOI":"10.3389\/fped.2022.982996","article-title":"Effects of strength exercise interventions in pediatric leukemia","volume":"10","author":"Gaser","year":"2022","journal-title":"Front Pediatr"},{"key":"B52","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.trecan.2020.12.003","article-title":"Exercise benefits meet cancer immunosurveillance","volume":"7","author":"Fiuza-Luces","year":"2021","journal-title":"Trends Cancer"},{"key":"B53","doi-asserted-by":"publisher","first-page":"e29953","DOI":"10.1002\/pbc.29953","article-title":"Multidisciplinary network ActiveOncoKids guidelines for providing movement and exercise in pediatric oncology: consensus-based recommendations","volume":"69","author":"G\u00f6tte","year":"2022","journal-title":"Pediatr Blood Cancer"},{"key":"B54","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S2352-4642(22)00306-6","article-title":"Childhood cancer: exercise is medicine","volume":"7","author":"Fiuza-Luces","year":"2023","journal-title":"Lancet Child Adolesc Health"},{"key":"B55","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/s41577-023-00943-0","article-title":"Effect of physical exercise on anticancer immunity","volume":"24","author":"Fiuza-Luces","year":"2024","journal-title":"Nat Rev Immunol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1002\/pbc.22698","article-title":"Effect of adapted physical activity sessions in the hospital on health-related quality of life for children with cancer: a cross-over randomized trial","volume":"55","author":"Speyer","year":"2010","journal-title":"Pediatr Blood Cancer"},{"key":"B57","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1002\/pbc.23320","article-title":"A revision of the intensity of treatment rating scale: classifying the intensity of pediatric cancer treatment","volume":"59","author":"Kazak","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"B58","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1200\/JCO-25-01649","article-title":"If exercise were a pill, we\u2019d all prescribe it to patients with cancer. But it\u2019s not","volume":"44","author":"Schmitz","year":"2026","journal-title":"J Clin Oncol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.jsams.2019.05.003","article-title":"The exercise and sports science Australia position statement: exercise medicine in cancer management","volume":"22","author":"Hayes","year":"2019","journal-title":"J Sci Med Sport"},{"key":"B60","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1249\/MSS.0000000000002116","article-title":"Exercise guidelines for cancer survivors: consensus statement","volume":"51","author":"Campbell","year":"2019","journal-title":"Med Sci Sports Exerc"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1907775\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:31:02Z","timestamp":1789623062000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1907775\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":60,"alternative-id":["10.3389\/fped.2026.1907775"],"URL":"https:\/\/doi.org\/10.3389\/fped.2026.1907775","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,17]]},"article-number":"1907775"}}