{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:31:45Z","timestamp":1786516305514,"version":"build-2736575974"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Oblique vaginal septum syndrome (Herlyn-Werner-Wunderlich syndrome) is a congenital reproductive tract malformation frequently accompanied by ipsilateral renal dysplasia. During infancy, it can lead to urinary tract infections, dysuria, and abdominal masses. Delayed intervention predisposes patients to hydronephrosis and even renal failure. Current treatment primarily involves incision and drainage; however, traditional transvaginal surgery in infants is limited by a restricted surgical field and a lack of standardized protocols. This case report presents the clinical data of three affected infants (age range: 5 days to 4 months and 15 days) treated at our institution, evaluating the efficacy of two minimally invasive surgical approaches. During a follow-up period of 1\u201312 months postoperatively, all patients achieved complete recovery of normal voiding function, with no recurrence of urinary tract infections, and no instances of intestinal injury, hemorrhage, or restenosis were observed. Transvaginal direct incision is considered suitable for patients presenting with vulvar masses caused by a low-positioned oblique septum, whereas a laparoscopy-assisted approach effectively optimizes surgical conditions for cases involving a high-positioned oblique septum or those with significant inflammation following repeated punctures. Both techniques resulted in symptom relief without major complications. We emphasize the importance of early and precise intervention, as well as the avoidance of blind puncture, to preserve renal function.<\/jats:p>","DOI":"10.3389\/fped.2026.1912583","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:59:50Z","timestamp":1786514390000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Herlyn-Werner-Wunderlich syndrome in three infants: a case report of surgical treatment"],"prefix":"10.3389","volume":"14","author":[{"given":"Jiarong","family":"Chen","sequence":"first","affiliation":[{"name":"Graduate School, Guangxi University of Chinese Medicine","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youcai","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Urology, Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danping","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Urology, Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second Affiliated Hospital of Guangxi University of Chinese Medicine","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e947938","DOI":"10.12659\/AJCR.947938","article-title":"Term pregnancy in Herlyn-Werner-Wunderlich syndrome: successful management of congenital obstructed hemivagina and ipsilateral renal agenesis (OHVIRA)","volume":"26","author":"Alqntash","year":"2025","journal-title":"Am J Case Rep"},{"key":"B2","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3390\/jcm15010190","article-title":"Diagnostic challenges of OHVIRA syndrome-A case report","volume":"15","author":"Tomecka","year":"2025","journal-title":"J Clin Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"480.e17","DOI":"10.1016\/j.crad.2020.01.016","article-title":"Herlyn-Werner-Wunderlich syndrome: diverse presentations and diagnosis on MRI","volume":"75","author":"Zhang","year":"2020","journal-title":"Clin Radiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.jmig.2023.02.007","article-title":"Vaginoscopic management of OHVIRA (obstructive hemivagina and ipsilateral renal agenesis)","volume":"30","author":"Paul","year":"2023","journal-title":"J Minim Invasive Gynecol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3731","DOI":"10.1080\/01443615.2022.2158313","article-title":"Diagnosis and treatment of 46 patients with oblique vaginal septum syndrome","volume":"42","author":"Zhang","year":"2022","journal-title":"J Obstet Gynaecol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"214","DOI":"10.31729\/jnma.8520","article-title":"Herlyn-Werner-Wunderlich syndrome with hydrocolpos: a case report","volume":"62","author":"Oli","year":"2024","journal-title":"JNMA J Nepal Med Assoc"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e32264","DOI":"10.1097\/MD.0000000000032264","article-title":"Laparoscopy combined with transvaginal surgery for Herlyn-Werner-Wunderlich syndrome: a case report","volume":"101","author":"Niu","year":"2022","journal-title":"Medicine (Baltimore)"},{"key":"B8","doi-asserted-by":"publisher","first-page":"653.e1","DOI":"10.1016\/j.jpurol.2021.06.023","article-title":"Multiple variants of obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome - one clinical center case series and the systematic review of 734 cases","volume":"17","author":"Kudela","year":"2021","journal-title":"J Pediatr Urol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.3390\/diagnostics12102466","article-title":"Herlyn-Werner-Wunderlich syndrome: case report and review of the literature","volume":"12","author":"Panaitescu","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e13270","DOI":"10.1111\/ases.13270","article-title":"Successful pneumovaginoscopic surgery for recurrent abscess of OHVIRA syndrome, preventing further recurrence and subsequent pregnancy","volume":"17","author":"Kita","year":"2024","journal-title":"Asian J Endosc Surg"},{"key":"B11","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/j.jmig.2022.05.002","article-title":"Conservative treatment of didelphyc uterus with obstructed hemivagina and ipsilateral renal agenesis","volume":"29","author":"Candiani","year":"2022","journal-title":"J Minim Invasive Gynecol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/ijgo.70164","article-title":"Clinical features and surgical options of obstructed hemivagina and ipsilateral renal agenesis (OHVIRA) syndrome: a systematic review and a meta-analysis of prevalence","volume":"171","author":"Bonetti","year":"2025","journal-title":"Int J Gynaecol Obstet"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1007\/s00404-022-06856-y","article-title":"Anatomical variations, treatment and outcomes of Herlyn-Werner-Wunderlich syndrome: a literature review of 1673 cases","volume":"308","author":"Liu","year":"2023","journal-title":"Arch Gynecol Obstet"},{"key":"B14","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1055\/a-2680-6011","article-title":"MRI-based Stratification and surgical management of hydrocolpos in children and adolescents","volume":"36","author":"AbouZeid","year":"2026","journal-title":"Eur J Pediatr Surg"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1912583\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:59:51Z","timestamp":1786514391000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1912583\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":14,"alternative-id":["10.3389\/fped.2026.1912583"],"URL":"https:\/\/doi.org\/10.3389\/fped.2026.1912583","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]},"article-number":"1912583"}}