{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:04:39Z","timestamp":1789538679016,"version":"build-2803163510"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to measure soluble leukocyte differentiation antigen 14 (presepsin) levels in umbilical cord blood from neonates with risk factors for early-onset sepsis (EOS). The objectives were to evaluate presepsin's diagnostic value for EOS and determine its optimal diagnostic cutoff in umbilical cord blood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>In this single-center prospective study, we enrolled neonates born between June 2024 and September 2025 at our hospital who presented with EOS risk factors. Infants were stratified into two groups based on EOS development: the EOS group and the non-EOS group. Within 24\u2005h of birth, umbilical cord blood and venous blood samples were collected for analysis. We measured presepsin levels in cord blood and evaluated complete blood counts, C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) in both cord and peripheral blood. These biomarkers were compared to assess presepsin's diagnostic performance relative to traditional inflammatory markers for neonatal EOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 195 eligible neonates. Umbilical cord presepsin levels were significantly elevated in the EOS group compared to controls (1,084.51\u2005pg\/mL vs. 618.94\u2005pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). Presepsin demonstrated higher diagnostic accuracy than traditional biomarkers (white blood cell (WBC), CRP, PCT, and IL-6) for EOS detection. Based on our analysis, the maximum Youden index was 0.726, corresponding to an optimal cutoff value of 800.91\u2005pg\/mL for umbilical cord blood presepsin in predicting neonatal EOS, with a sensitivity of 88.0%, specificity of 84.6%, and the area under the curve (AUC) of 0.941.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Umbilical cord presepsin showed higher diagnostic accuracy than traditional inflammatory markers for neonatal EOS. and the optimal cut-off value of umbilical-blood presepsin to predict EOS was 800.91\u2005pg\/mL.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical Trial Registration<\/jats:bold>\n                      :\n                      <jats:ext-link>https:\/\/www.chictr.org.cn\/showproj.aspx?proj=194627<\/jats:ext-link>\n                      , identifier ChiCTR2300072525.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1916996","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:31:03Z","timestamp":1789536663000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of umbilical cord blood presepsin in the diagnosis of neonatal early-onset sepsis"],"prefix":"10.3389","volume":"14","author":[{"given":"Huaqing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Peking University Shenzhen Hospital","place":["Shenzhe, Guandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Peking University Shenzhen Hospital","place":["Shenzhe, Guandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Peking University Shenzhen Hospital","place":["Shenzhen, Guandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Peking University Shenzhen Hospital","place":["Shenzhe, Guandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3390\/children7120309","article-title":"Relevance of biomarkers currently in use or research for practical diagnosis approach of neonatal early-onset 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