{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:02:42Z","timestamp":1790146962711,"version":"4.0.1"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>\n                    This case reports a 10 day old neonate with fulminant\n                    <jats:italic>Elizabethkingia anophelis<\/jats:italic>\n                    sepsis presenting as disseminated infection involving meningitis and intestinal necrosis. Pathogen identification was achieved on hospital day 2 by metagenomic next generation sequencing and confirmed by blood and cerebrospinal fluid cultures, enabling antimicrobial susceptibility guided therapy. The infant was treated with cefoperazone sulbactam plus levofloxacin on day 3, switched to levofloxacin plus trimethoprim sulfamethoxazole (TMP SMX) on day 10, and stepped down to oral TMP SMX on day 24, completing a 42 day course (24 days intravenous and 18 days oral). Concurrently, three surgical interventions, including bowel resection, burr hole drainage, and Ommaya reservoir placement, were performed to address intestinal perforation and intracranial complications. At 4 months of corrected age, the infant showed age appropriate neurodevelopment with no recurrence or sequelae. This successful outcome underscores that prompt diagnostics, susceptibility driven antibiotic optimization, and a coordinated multidisciplinary surgical medical approach are essential for managing life threatening neonatal\n                    <jats:italic>Elizabethkingia anophelis<\/jats:italic>\n                    infections, even in the setting of severe multisystem involvement.\n                  <\/jats:p>","DOI":"10.3389\/fped.2026.1920161","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:24:50Z","timestamp":1790144690000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: A neonatal case of Elizabethkingia anophelis sepsis complicated by meningitis and intestinal necrosis: a triumph of multidisciplinary management"],"prefix":"10.3389","volume":"14","author":[{"given":"Ziao","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Medicine, Department of Medicine, Wuhan University of Science and Technology","place":["Wuhan, China"]},{"name":"Division of Neonatology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology","place":["Wuhan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Outpatient, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology","place":["Wuhan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuwei","family":"Tao","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology","place":["Wuhan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1099\/ijs.0.026393-0","article-title":"Elizabethkingia anophelis sp. Nov., isolated from the midgut of the mosquito anopheles gambiae","volume":"61","author":"K\u00e4mpfer","year":"2011","journal-title":"Int J Syst Evol Microbiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1016\/S0140-6736(13)60318-9","article-title":"First case of elizabethkingia anophelis meningitis in the Central African Republic","volume":"381","author":"Frank","year":"2013","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"708","DOI":"10.18295\/2075-0528.2895","article-title":"Elizabethkingia infections\u2014an important emerging cause of sepsis and meningitis in neonates and infants: case series from north batinah region, Oman, and literature review","volume":"25","author":"AI Reesi","year":"2025","journal-title":"Sultan Qaboos Univ Med J"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.11816\/cn.ni.2025-246574","article-title":"Clinical characteristics and drug resistance of 53 strains of Elizabethkingia anophelis","volume":"35","author":"Caiyun","year":"2025","journal-title":"Chin J Nosocomiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3188","DOI":"10.11816\/cn.ni.2025-250570","article-title":"Progress of research on epidemiology and drug resistance mechanism of Elizabethkingia anopheles infection","volume":"35","author":"Jie","year":"2025","journal-title":"Chin J Nosocomiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"521","DOI":"10.3760\/cma.j.issn.1673-4408.2023.08.005","article-title":"Progress of neonatal infection with elizabethkingia anophelis","volume":"50","author":"Shangguan","year":"2023","journal-title":"Int J Pediatr"},{"key":"B7","doi-asserted-by":"publisher","first-page":"107544","DOI":"10.1016\/j.actatropica.2025.107544","article-title":"A systematic review of reported symptomatic elizabethkingia infection cases in children and adults","volume":"263","author":"Jiang","year":"2025","journal-title":"Acta Trop"},{"key":"B8","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1186\/s12866-026-04846-7","article-title":"Genomic perspectives on the global dissemination of elizabethkingia anophelis: unveiling inherent multidrug resistance and virulence determinants","volume":"26","author":"Hu","year":"2026","journal-title":"BMC Microbiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"278","DOI":"10.3390\/pathogens15030278","article-title":"Elizabethkingia species as an emerging pathogen: a comprehensive review of clinical and microbiological evidence","volume":"15","author":"Tan","year":"2026","journal-title":"Pathogens"},{"key":"B10","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1177\/00494755231180004","article-title":"Elizabethkingia meningosepticum infections with varied presentations and different antimicrobial susceptibility\u2014a case series","volume":"53","author":"Krishnan","year":"2023","journal-title":"Trop Doct"},{"key":"B11","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3390\/microorganisms7090295","article-title":"Elizabethkingia infections in humans: from genomics to clinics","volume":"7","author":"Lin","year":"2019","journal-title":"Microorganisms"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.3390\/ijms25042215","article-title":"Antibiotic combination to effectively postpone or inhibit the in vitro induction and selection of levofloxacin-resistant mutants in elizabethkingia anophelis","volume":"25","author":"Lee","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1330900","DOI":"10.3389\/fcimb.2023.1330900","article-title":"Role of gut microbiota and bacterial translocation in acute intestinal injury and mortality in patients admitted in ICU for septic shock","volume":"13","author":"Magnan","year":"2023","journal-title":"Front Cell Infect Microbiol"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1920161\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:24:58Z","timestamp":1790144698000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2026.1920161\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":13,"alternative-id":["10.3389\/fped.2026.1920161"],"URL":"https:\/\/doi.org\/10.3389\/fped.2026.1920161","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"article-number":"1920161"}}