{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:05:27Z","timestamp":1789387527403,"version":"build-2803163510"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"\n Background<\/jats:title>\n Immunoglobulin A vasculitis (IgAV) is the most common childhood vasculitis, and involvement of multiple systems (gastrointestinal, joint, renal) may affect prognosis. Reliable biomarkers for predicting multi-system involvement are needed.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To investigate the association between routine inflammation-related laboratory indicators and multi-system involvement in children with IgAV.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A retrospective study included 657 children with IgAV diagnosed according to EULAR\/PRINTO\/PRES criteria. Patients were categorized into five mutually exclusive subgroups based on clinical phenotypes: skin only (\n n<\/jats:italic>\n \u2009=\u200975), gastrointestinal (GI,\n n<\/jats:italic>\n \u2009=\u200996), joint (\n n<\/jats:italic>\n \u2009=\u2009158), kidney (\n n<\/jats:italic>\n \u2009=\u200931), and multi-system (\n n<\/jats:italic>\n \u2009=\u2009297) involvement. Laboratory parameters including white blood cell (WBC), neutrophils, platelets, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), albumin, and D-dimer were compared across groups. Generalized additive models (GAM) and ROC curve analysis were used to determine optimal cut-off values for age and disease duration.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Multi-system involvement was the most common phenotype (45.2%). Compared with other subgroups, multi-system involvement patients showed significantly higher WBC (\n P<\/jats:italic>\n \u2009=\u20090.032), neutrophils (\n P<\/jats:italic>\n \u2009=\u20090.001), platelets (\n P<\/jats:italic>\n \u2009=\u20090.002), NLR (\n P<\/jats:italic>\n \u2009=\u20090.001), PLR (\n P<\/jats:italic>\n \u2009=\u20090.002), and D-dimer, while albumin was lowest (\n P<\/jats:italic>\n \u2009&lt;\u20090.001). Pairwise comparisons revealed that NLR and PLR elevations were most pronounced between multi-system and skin-only groups. GAM analysis identified 10 years as the optimal cut-off for onset age; children &gt;10 years had significantly higher renal involvement rates (25.49% vs. 11.39%,\n P<\/jats:italic>\n \u2009&lt;\u20090.001) and higher NLR (\n P<\/jats:italic>\n \u2009=\u20090.019) than those \u226410 years. Multivariate logistic regression identified female sex (OR\u2009=\u20091.650,\n P<\/jats:italic>\n \u2009=\u20090.038), onset age &gt;10 years (OR\u2009=\u20092.160,\n P<\/jats:italic>\n \u2009=\u20090.036), and longer disease duration (OR\u2009=\u20091.059,\n P<\/jats:italic>\n \u2009=\u20090.037) as independent risk factors for renal involvement.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Elevated inflammatory markers including WBC, neutrophils, platelets, NLR, PLR, and D-dimer, as well as decreased albumin, are associated with multi-system involvement in children with IgAV, with the most pronounced differences observed between multi-system and skin-only groups. Onset age &gt;10 years is associated with increased renal involvement risk. These routine laboratory indicators, interpreted in conjunction with age and disease duration, may aid in early risk stratification.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fped.2026.1921404","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:24:47Z","timestamp":1789385087000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of the inflammation indicators with multiple system involved of immunoglobulin A vasculitis in children"],"prefix":"10.3389","volume":"14","author":[{"given":"Hao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology, Children\u2019s Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Children\u2019s Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children\u2019s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.3390\/jcm14093055","article-title":"Laboratory findings and clinical features in IgA vasculitis: identifying predictors of kidney involvement and disease relapse in pediatric patients","volume":"14","author":"Podraza","year":"2025","journal-title":"J Clin Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-026-07382-8","article-title":"Biomarkers of kidney involvement in paediatric IgA vasculitis: a systematic review and meta-analysis","author":"Beltie","year":"2026","journal-title":"Pediatr Nephrol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3390\/biomedicines13010113","article-title":"The impact of infectious diseases on clinical characteristics and immunological correlations in pediatric Henoch-Sch\u00f6nlein purpura: a five-year retrospective study","volume":"13","author":"Opri\u021bescu","year":"2025","journal-title":"Biomedicines"},{"key":"B4","doi-asserted-by":"publisher","first-page":"279","DOI":"10.2147\/JMDH.S499808","article-title":"Predictive laboratory markers for gastrointestinal complications in children with henoch-sch\u00f6nlein Purpura","volume":"18","author":"Guo","year":"2025","journal-title":"J Multidiscip Healthc"},{"key":"B5","doi-asserted-by":"publisher","first-page":"113063","DOI":"10.1016\/j.intimp.2024.113063","article-title":"Blood soluble CD89-IgA complex may be a potential biomarker for predicting multi-organ involvement, especially renal involvement in children with immunoglobulin A vasculitis","volume":"142","author":"Yu","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"683","DOI":"10.7499\/j.issn.1008-8830.2311151","article-title":"[Exploring the mechanism of IgA vasculitis pathogenesis through the interaction of thrombin and inflammatory factors using urinary proteomics]","volume":"26","author":"Liu","year":"2024","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"B7","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1136\/ard.2009.116657","article-title":"EULAR\/PRINTO\/PRES criteria for henoch-sch\u00f6nlein purpura, childhood polyarteritis nodosa, childhood wegener granulomatosis and childhood takayasu arteritis: ankara 2008. 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