{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:56:03Z","timestamp":1790751363107,"version":"4.1.0"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Gastric heterotopia (GH) is a developmental anomaly characterized by the presence of ectopic gastric mucosa outside its normal location. It is rare in the duodenum, particularly as a large polypoid lesion in children. We report the case of a 12-year-old boy who developed recurrent postprandial nausea and vomiting at 11 years of age. Imaging and endoscopy revealed a large partially obstructing polypoid mass in the distal duodenum. Technetium-99m pertechnetate scintigraphy demonstrated ectopic gastric mucosa. The lesion was successfully removed through a two-stage endoscopic resection, leading to complete symptom resolution. Histopathological examination confirmed a hyperplastic polyp arising from heterotopic gastric mucosa in the distal duodenum. This case highlights that polypoid duodenal GH should be considered in children presenting with chronic unexplained vomiting or symptoms of partial upper intestinal obstruction. Complete resection resulted in symptom resolution in our patient and may be achieved endoscopically in selected cases.<\/jats:p>","DOI":"10.3389\/fped.2026.1931161","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:05:30Z","timestamp":1790748330000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A rare cause of recurrent vomiting: large polypoid duodenal gastric heterotopia. A case report with a focused review of the paediatric literature"],"prefix":"10.3389","volume":"14","author":[{"given":"Martina","family":"Begucci","sequence":"first","affiliation":[{"name":"Postgraduate School of Pediatrics, University of Bari Aldo Moro","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Natalizio","sequence":"additional","affiliation":[{"name":"Postgraduate School of Pediatrics, University of Bari Aldo Moro","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Tambucci","sequence":"additional","affiliation":[{"name":"Pediatric Hospital Bambino Ges\u00f9 IRCCS, Gastroenterology and Nutrition Unit","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Sgarro","sequence":"additional","affiliation":[{"name":"University of Bari Aldo Moro, Interdisciplinary Department of Medicine-Pediatric Section","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Marzullo","sequence":"additional","affiliation":[{"name":"University of Bari Aldo Moro, Interdisciplinary Department of Medicine-Pediatric Section","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Gaeta","sequence":"additional","affiliation":[{"name":"Pediatric Hospital Giovanni XXIII- Department of Radiology","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruggiero","family":"Francavilla","sequence":"additional","affiliation":[{"name":"University of Bari Aldo Moro, Interdisciplinary Department of Medicine-Pediatric Section","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Dall'Oglio","sequence":"additional","affiliation":[{"name":"Pediatric Hospital Bambino Ges\u00f9 IRCCS, Gastroenterology and Nutrition Unit","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Cristofori","sequence":"additional","affiliation":[{"name":"University of Bari Aldo Moro, Interdisciplinary Department of Medicine-Pediatric Section","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e04633","DOI":"10.1002\/ccr3.4633","article-title":"Endoscopic resection of a large polypoid gastric heterotopia of duodenum: a case report","volume":"9","author":"Maione","year":"2021","journal-title":"Clin Case Rep"},{"key":"B2","doi-asserted-by":"publisher","first-page":"8822019","DOI":"10.1155\/2020\/8822019","article-title":"Jejunal polyps out of place: a case of gastric heterotopia of the jejunum","volume":"2020","author":"Urquhart","year":"2020","journal-title":"Case Rep Gastrointest Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s100249910036","article-title":"Extensive gastric heterotopia of the small intestine resulting in massive gastrointestinal bleeding, bowel perforation, and death: report of a case and review of the literature","volume":"3","author":"Lambert","year":"2000","journal-title":"Pediatr Dev Pathol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1641000","DOI":"10.3389\/fped.2025.1641000","article-title":"Heterotopic gastric mucosa in the second part of the duodenum causing hemorrhage in a child: a case report and literature review","volume":"13","author":"Huang","year":"2025","journal-title":"Front. 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