{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:09:07Z","timestamp":1789711747754,"version":"4.0.1"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially fatal inherited arrhythmia syndrome triggered by exercise or emotional stress that may mimic epileptic seizures, resulting in delayed diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      We report the case of a 6-year-old girl with recurrent transient loss of consciousness (T-LOC) who was initially misdiagnosed with epilepsy. She experienced three episodes of T-LOC between 4 and 6 years of age. The first two episodes occurred during or immediately post-exercise, whereas the third appeared non-exertional; however, retrospective review suggested fear-induced sympathetic activation as the trigger. During the second and third episodes, she exhibited eye opening, fixed gaze, and tonic posturing, closely resembling epileptic seizures. Interictal electroencephalography was normal, resting electrocardiography (ECG) showed sinus bradycardia without QT prolongation, and an initial Master's triple two-step exercise test increased the heart rate to only 74 beats per minute (bpm) without inducing arrhythmia. She was provisionally diagnosed with epilepsy, and a diagnostic trial of levetiracetam was initiated. Four months later, school-based ECG screening, prompted by her history of seizure-like episodes with impaired consciousness, led to further cardiac evaluation, which revealed bigeminal premature ventricular contractions. Subsequent treadmill exercise testing at a tertiary center induced bidirectional ventricular tachycardia at a heart rate of 144 bpm, confirming the diagnosis of CPVT. Genetic testing identified a pathogenic ryanodine receptor 2 (\n                      <jats:italic>RYR2)<\/jats:italic>\n                      variant (c.11836G\u2009&amp;gt;\u2009A, p.Gly3946Ser). Treatment with nadolol and flecainide was initiated, levetiracetam was discontinued, and she has remained free of syncope and seizure-like episodes for &amp;gt;2 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the diagnostic challenges of CPVT, and underscores the need for specialized evaluation, including repeat exercise testing under varying conditions, in children with exercise- or emotion-induced T-LOC suggestive of cardiac syncope.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fped.2026.1950509","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:39:05Z","timestamp":1789709945000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Catecholaminergic polymorphic ventricular tachycardia with diagnostic difficulty differentiating seizures from syncope: a case report"],"prefix":"10.3389","volume":"14","author":[{"given":"Takato","family":"Akiba","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Juntendo University Shizuoka Hospital","place":["Shizuoka, Japan"]},{"name":"Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine","place":["Tokyo, Japan"]},{"name":"National Epilepsy Center, NHO Shizuoka Institute of Epilepsy and Neurological Disorders","place":["Shizuoka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shino","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Juntendo University Shizuoka Hospital","place":["Shizuoka, Japan"]},{"name":"Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine","place":["Tokyo, Japan"]},{"name":"Medical Genomics Center, National Institute of Global Health and Medicine","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kantaro","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Juntendo University Shizuoka Hospital","place":["Shizuoka, Japan"]},{"name":"Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Juntendo University Shizuoka Hospital","place":["Shizuoka, Japan"]},{"name":"Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Shoji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Juntendo University Shizuoka Hospital","place":["Shizuoka, Japan"]},{"name":"Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Arrhythmia Medicine, Shizuoka Children's Hospital","place":["Shizuoka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1093\/eurheartj\/ehy037","article-title":"2018 ESC guidelines for the diagnosis and management of syncope","volume":"39","author":"Brignole","year":"2018","journal-title":"Eur Heart J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1161\/CIRCULATIONAHA.105.170274","article-title":"AHA\/ACCF scientific statement on the evaluation of syncope: from the American Heart Association councils on clinical cardiology, cardiovascular nursing, cardiovascular disease in the young, and stroke, and the quality of care and outcomes research interdisciplinary working group; 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