{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:57:46Z","timestamp":1789757866918,"version":"4.0.1"},"reference-count":176,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2014.00099","type":"journal-article","created":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T14:00:03Z","timestamp":1399471203000},"source":"Crossref","is-referenced-by-count":143,"title":["Neurodegeneration with brain iron accumulation: update on pathogenic mechanisms"],"prefix":"10.3389","volume":"5","author":[{"given":"Sonia","family":"Levi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Finazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2014,5,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.3324\/haematol.2011.043018","article-title":"A pilot trial of deferiprone for neurodegeneration with brain iron accumulation.","volume":"96","author":"Abbruzzese","year":"2011","journal-title":"Haematologica"},{"key":"B2","doi-asserted-by":"crossref","first-page":"9227","DOI":"10.1016\/S0021-9258(17)37098-9","article-title":"Ca(2+)-independent cytosolic phospholipase A2 from macrophage-like P388D1 cells. Isolation and characterization.","volume":"269","author":"Ackermann","year":"1994","journal-title":"J. Biol. Chem."},{"key":"B3","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/genetics\/157.3.1267","article-title":"fumble encodes a pantothenate kinase homolog required for proper mitosis and meiosis in Drosophila melanogaster.","volume":"157","author":"Afshar","year":"2001","journal-title":"Genetics"},{"issue":"e49509","key":"B4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049509","article-title":"Compartmentalization of mammalian pantothenate kinases.","volume":"7","author":"Alfonso-Pecchio","year":"2012","journal-title":"PLoS ONE"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/embor.2013.168","article-title":"Loss of iron triggers PINK1\/Parkin-independent mitophagy.","volume":"14","author":"Allen","year":"2013","journal-title":"EMBO Rep."},{"key":"B6","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.bbagen.2010.02.005","article-title":"Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage.","volume":"1800","author":"Arosio","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1111\/j.1742-4658.2008.06350.x","article-title":"Calcium-independent phospholipase A2 mediates proliferation of human promonocytic U937 cells.","volume":"275","author":"Balboa","year":"2008","journal-title":"dFEBS J."},{"key":"B8","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/S0014-5793(02)03481-6","article-title":"Expression and function of phospholipase A(2) in brain.","volume":"531","author":"Balboa","year":"2002","journal-title":"FEBS Lett."},{"key":"B9","doi-asserted-by":"publisher","first-page":"16069","DOI":"10.1074\/jbc.272.26.16069","article-title":"Function and inhibition of intracellular calcium-independent phospholipase A2.","volume":"272","author":"Balsinde","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"38194","DOI":"10.1074\/jbc.M406489200","article-title":"Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility.","volume":"279","author":"Bao","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"31679","DOI":"10.1074\/jbc.M805532200","article-title":"Iron-mediated aggregation and a localized structural change characterize ferritin from a mutant light chain polypeptide that causes neurodegeneration.","volume":"283","author":"Baraibar","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1016\/j.freeradbiomed.2012.02.015","article-title":"A mutant light-chain ferritin that causes neurodegeneration has enhanced propensity toward oxidative damage.","volume":"52","author":"Baraibar","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1074\/jbc.M109.042986","article-title":"Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration.","volume":"285","author":"Baraibar","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1111\/j.1471-4159.2009.06028.x","article-title":"Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene.","volume":"109","author":"Barbeito","year":"2009","journal-title":"J. Neurochem."},{"issue":"50","key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-5-50","article-title":"Abnormal iron metabolism in fibroblasts from a patient with the neurodegenerative disease hereditary ferritinopathy.","volume":"5","author":"Barbeito","year":"2010","journal-title":"Mol. Neurodegener."},{"key":"B16","doi-asserted-by":"publisher","first-page":"11411","DOI":"10.1523\/JNEUROSCI.0345-11.2011","article-title":"Neuroaxonal dystrophy in calcium-independent phospholipase A2\u00ce\u00b2 deficiency results from insufficient remodeling and degeneration of mitochondrial and presynaptic membranes.","volume":"31","author":"Beck","year":"2011","journal-title":"J. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature09204","article-title":"Network organization of the human autophagy system.","volume":"466","author":"Behrends","year":"2010","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1093\/hmg\/ddn105","article-title":"De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system.","volume":"17","author":"Bosveld","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1093\/hmg\/dds089","article-title":"Mutation of the parkinsonism gene ATP13A2 causes neuronal ceroid-lipofuscinosis.","volume":"21","author":"Bras","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B20","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.bbagen.2011.07.014","article-title":"Non-transferrin bound iron: a key role in iron overload and iron toxicity.","volume":"1820","author":"Brissot","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"B21","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/brain\/awt325","article-title":"Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model.","volume":"137(Pt 1)","author":"Brunetti","year":"2014","journal-title":"Brain"},{"key":"B22","doi-asserted-by":"publisher","first-page":"5294","DOI":"10.1093\/hmg\/dds380","article-title":"Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model.","volume":"21","author":"Brunetti","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B23","doi-asserted-by":"publisher","first-page":"S237","DOI":"10.1194\/jlr.R800033-JLR200","article-title":"Phospholipase A2 structure\/function, mechanism, and signaling.","volume":"50(Suppl.)","author":"Burke","year":"2009","journal-title":"J. Lipid Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"4049","DOI":"10.1093\/hmg\/dds229","article-title":"Skin fibroblasts from pantothenate kinase-associated neurodegeneration patients show altered cellular oxidative status and have defective iron-handling properties.","volume":"21","author":"Campanella","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B25","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1093\/brain\/awl319","article-title":"Clinical features and natural history of neuroferritinopathy caused by the FTL1 460InsA mutation.","volume":"130(Pt 1)","author":"Chinnery","year":"2007","journal-title":"Brain"},{"key":"B26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00005072-196304000-00001","article-title":"Infantile neuroaxonal dystrophy.","volume":"22","author":"Cowen","year":"1963","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.nbd.2009.09.009","article-title":"Oxidative stress and cell death in cells expressing L-ferritin variants causing neuroferritinopathy.","volume":"37","author":"Cozzi","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"B28","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.nbd.2006.05.004","article-title":"Characterization of the L-ferritin variant 460InsA responsible of a hereditary ferritinopathy disorder.","volume":"23","author":"Cozzi","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1006\/bcmd.2002.0589","article-title":"Neuroferritinopathy: a window on the role of iron in neurodegeneration.","volume":"29","author":"Crompton","year":"2002","journal-title":"Blood Cells Mol. Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.ymgme.2010.02.009","article-title":"Multiplex ligation-dependent probe amplification (MLPA) analysis is an effective tool for the detection of novel intragenic PLA2G6 mutations: implications for molecular diagnosis.","volume":"100","author":"Crompton","year":"2010","journal-title":"Mol. Genet. Metab."},{"key":"B31","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.jtemb.2009.05.004","article-title":"Age-dependent expression of hephaestin in the brain of ceruloplasmin-deficient mice.","volume":"23","author":"Cui","year":"2009","journal-title":"J. Trace Elem. Med. Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/ng571","article-title":"Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease.","volume":"28","author":"Curtis","year":"2001","journal-title":"Nat. Genet."},{"key":"B33","doi-asserted-by":"publisher","first-page":"9611","DOI":"10.1073\/pnas.1112368109","article-title":"Loss of P-type ATPase ATP13A2\/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration.","volume":"109","author":"Dehay","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B34","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.neulet.2010.05.025","article-title":"Accumulation of oxidative DNA damage in brain mitochondria in mouse model of hereditary ferritinopathy.","volume":"479","author":"Deng","year":"2010","journal-title":"Neurosci. Lett."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5593","article-title":"Targeting chelatable iron as a therapeutic modality in Parkinson\u00e2\u20ac\u2122s disease.","author":"Devos","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"e109","key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn274","article-title":"Clinical features and natural history of neuroferritinopathy caused by the 458dupA FTL mutation.","volume":"132(Pt 6)","author":"Devos","year":"2009","journal-title":"Brain"},{"key":"B37","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1002\/cmmi.1482","article-title":"Two forms of iron as an intrinsic contrast agent in the basal ganglia of PKAN patients.","volume":"7","author":"Dezortova","year":"2012","journal-title":"Contrast Media Mol. Imaging"},{"key":"B38","doi-asserted-by":"publisher","first-page":"E1251","DOI":"10.1002\/humu.21205","article-title":"Mutation of FA2H underlies a complicated form of hereditary spastic paraplegia (SPG35).","volume":"31","author":"Dick","year":"2010","journal-title":"Hum. Mutat."},{"key":"B39","doi-asserted-by":"publisher","first-page":"4545","DOI":"10.1074\/jbc.M805688200","article-title":"Dominant mutants of ceruloplasmin impair the copper loading machinery in aceruloplasminemia.","volume":"284","author":"di Patti","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/B978-0-12-410502-7.00010-7","article-title":"Imaging of iron.","volume":"110","author":"Dusek","year":"2013","journal-title":"Int. Rev. Neurobiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1097\/WCO.0b013e3283550cac","article-title":"Neurodegeneration with brain iron accumulation.","volume":"25","author":"Dusek","year":"2012","journal-title":"Curr. Opin. Neurol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1002\/mds.25424","article-title":"Neurodegenerative disorder with brain iron accumulation previously known as SENDA syndrome now genetically determined.","volume":"28","author":"Dusek","year":"2013","journal-title":"Mov. Disord."},{"key":"B43","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ajhg.2013.11.008","article-title":"Exome sequence reveals mutations in CoA synthase as a cause of neurodegeneration with brain iron accumulation.","volume":"94","author":"Dusi","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"B44","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.ajhg.2008.10.010","article-title":"Mutations in the fatty acid 2-hydroxylase gene are associated with leukodystrophy with spastic paraparesis and dystonia.","volume":"83","author":"Edvardson","year":"2008","journal-title":"Am. J. Hum. Genet."},{"issue":"e12897","key":"B45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012897","article-title":"Catalytic function of PLA2G6 is impaired by mutations associated with infantile neuroaxonal dystrophy but not dystonia-parkinsonism.","volume":"5","author":"Engel","year":"2010","journal-title":"PLoS ONE"},{"key":"B46","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s002340050768","article-title":"Infantile neuroaxonal dystrophy: neuroradiological studies in 11 patients.","volume":"41","author":"Farina","year":"1999","journal-title":"Neuroradiology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.jhep.2010.04.039","article-title":"Hepatic but not brain iron is rapidly chelated by deferasirox in aceruloplasminemia due to a novel gene mutation.","volume":"53","author":"Finkenstedt","year":"2010","journal-title":"J. Hepatol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.tips.2010.09.003","article-title":"Targeting the correct HDAC(s) to treat cognitive disorders.","volume":"31","author":"Fischer","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1002\/mds.22002","article-title":"Regression of symptoms after selective iron chelation therapy in a case of neurodegeneration with brain iron accumulation.","volume":"23","author":"Forni","year":"2008","journal-title":"Mov. Disord."},{"key":"B50","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0002-9440(10)64548-8","article-title":"Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology.","volume":"157","author":"Galvin","year":"2000","journal-title":"Am. J. Pathol."},{"issue":"e40871","key":"B51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040871","article-title":"Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism.","volume":"7","author":"Garcia","year":"2012","journal-title":"PLoS ONE"},{"key":"B52","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1111\/j.1440-1789.2008.00901.x","article-title":"Redox active iron accumulation in aceruloplasminemia.","volume":"28","author":"Gonzalez-Cuyar","year":"2008","journal-title":"Neuropathology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1194\/jlr.R700017-JLR200","article-title":"The emerging role of group VI calcium-independent phospholipase A2 in releasing docosahexaenoic acid from brain phospholipids.","volume":"49","author":"Green","year":"2008","journal-title":"J. Lipid Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1007\/s11910-011-0181-3","article-title":"Genetics of neurodegeneration with brain iron accumulation.","volume":"11","author":"Gregory","year":"2011","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"B55","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1136\/jmg.2008.061929","article-title":"Clinical and genetic delineation of neurodegeneration with brain iron accumulation.","volume":"46","author":"Gregory","year":"2009","journal-title":"J. Med. Genet."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1212\/01.wnl.0000327094.67726.28","article-title":"Neurodegeneration associated with genetic defects in phospholipase A(2).","volume":"71","author":"Gregory","year":"2008","journal-title":"Neurology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1843.e1","DOI":"10.1016\/j.neurobiolaging.2011.12.035","article-title":"ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor\u00e2\u20ac\u201cRakeb syndrome.","volume":"33","author":"Gr\u00c3\u00bcnewald","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.ajhg.2012.10.019","article-title":"Exome sequencing reveals de novo WDR45 mutations causing a phenotypically distinct, X-linked dominant form of NBIA.","volume":"91","author":"Haack","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2728","DOI":"10.1167\/iovs.07-1472","article-title":"Ceruloplasmin\/hephaestin knockout mice model morphologic and molecular features of AMD.","volume":"49","author":"Hadziahmetovic","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1167\/iovs.10-6207","article-title":"The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration.","volume":"52","author":"Hadziahmetovic","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"13850","DOI":"10.1073\/pnas.0405146101","article-title":"Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration.","volume":"101","author":"Hahn","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B62","doi-asserted-by":"crossref","first-page":"10812","DOI":"10.1073\/pnas.96.19.10812","article-title":"Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux.","volume":"96","author":"Harris","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B63","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/ana.20771","article-title":"Genotypic and phenotypic spectrum of PANK2 mutations in patients with neurodegeneration with brain iron accumulation.","volume":"59","author":"Hartig","year":"2006","journal-title":"Ann. Neurol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.ajhg.2011.09.007","article-title":"Absence of an orphan mitochondrial protein, c19orf12, causes a distinct clinical subtype of neurodegeneration with brain iron accumulation.","volume":"89","author":"Hartig","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1093\/brain\/awt095","article-title":"\u00ce\u00b2-Propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation.","volume":"136(Pt 6)","author":"Hayflick","year":"2013","journal-title":"Brain"},{"key":"B66","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1056\/NEJMoa020817","article-title":"Genetic, clinical, and radiographic delineation of Hallervorden\u00e2\u20ac\u201cSpatz syndrome.","volume":"348","author":"Hayflick","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1074\/jbc.M109123200","article-title":"Biochemical analysis of a missense mutation in aceruloplasminemia.","volume":"277","author":"Hellman","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B68","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1212\/WNL.0b013e31827e07be","article-title":"New NBIA subtype: genetic, clinical, pathologic, and radiographic features of MPAN.","volume":"80","author":"Hogarth","year":"2013","journal-title":"Neurology"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.bcp.2008.07.044","article-title":"Role of Ca2+-independent phospholipase A2 in cell growth and signaling.","volume":"76","author":"Hooks","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"B70","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/hmg\/ddg026","article-title":"An isoform of hPANK2, deficient in pantothenate kinase-associated neurodegeneration, localizes to mitochondria.","volume":"12","author":"H\u00c3\u00b6rtnagel","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"B71","doi-asserted-by":"publisher","first-page":"3003","DOI":"10.1089\/ars.2011.3921","article-title":"Mitochondrial mayhem: the mitochondrion as a modulator of iron metabolism and its role in disease.","volume":"15","author":"Huang","year":"2011","journal-title":"Antioxid. Redox. Signal."},{"key":"B72","first-page":"133","article-title":"Infantile neuroaxonal dystrophy \u00e2\u20ac\u201c immunohistochemical and ultrastructural studies on the central and peripheral nervous systems in infantile neuroaxonal dystrophy.","volume":"39","author":"Itoh","year":"1993","journal-title":"Kobe J. Med. Sci."},{"issue":"e89439","key":"B73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089439","article-title":"Impairment of Drosophila orthologs of the human orphan protein C19orf12 induces bang sensitivity and neurodegeneration.","volume":"9","author":"Iuso","year":"2014","journal-title":"PLoS ONE"},{"key":"B74","doi-asserted-by":"publisher","first-page":"27144","DOI":"10.1074\/jbc.M301988200","article-title":"Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system.","volume":"278","author":"Jeong","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B75","doi-asserted-by":"publisher","first-page":"9810","DOI":"10.1523\/JNEUROSCI.2922-06.2006","article-title":"Age-related changes in iron homeostasis and cell death in the cerebellum of ceruloplasmin-deficient mice.","volume":"26","author":"Jeong","year":"2006","journal-title":"J. Neurosci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1196\/annals.1306.023","article-title":"Mitochondrial localization of human PANK2 and hypotheses of secondary iron accumulation in pantothenate kinase-associated neurodegeneration.","volume":"1012","author":"Johnson","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.humpath.2011.05.016","article-title":"Extensive brain pathology in a patient with aceruloplasminemia with a prolonged duration of illness.","volume":"43","author":"Kaneko","year":"2012","journal-title":"Hum. Pathol."},{"key":"B78","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.2174\/138945012802002320","article-title":"Aceruloplasminemia.","volume":"13","author":"Kono","year":"2012","journal-title":"Curr. Drug Targets"},{"key":"B79","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/B978-0-12-41-0502-7.00007-7","article-title":"Aceruloplasminemia: an update.","volume":"110","author":"Kono","year":"2013","journal-title":"Int. Rev. Neurobiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4067\/S0716-97602006000100003","article-title":"Molecular and pathological basis of aceruloplasminemia.","volume":"39","author":"Kono","year":"2006","journal-title":"Biol. Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1385\/NMM:8:3:361","article-title":"Biochemical features of ceruloplasmin gene mutations linked to aceruloplasminemia.","volume":"8","author":"Kono","year":"2006","journal-title":"Neuromol. Med."},{"key":"B82","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.jhep.2007.05.013","article-title":"Cys-881 is essential for the trafficking and secretion of truncated mutant ceruloplasmin in aceruloplasminemia.","volume":"47","author":"Kono","year":"2007","journal-title":"J. Hepatol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.bbadis.2010.07.011","article-title":"Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin.","volume":"1802","author":"Kono","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"B84","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1523\/JNEUROSCI.4265-04.2005","article-title":"Altered neuronal mitochondrial coenzyme A synthesis in neurodegeneration with brain iron accumulation caused by abnormal processing, stability, and catalytic activity of mutant pantothenate kinase 2.","volume":"25","author":"Kotzbauer","year":"2005","journal-title":"J. Neurosci."},{"key":"B85","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.spen.2012.04.001","article-title":"Neurodegeneration with brain iron accumulation: a diagnostic algorithm","volume":"19","author":"Kruer","year":"2012","journal-title":"Semin. Pediatr. Neurol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1093\/brain\/awr042","article-title":"Novel histopathologic findings in molecularly-confirmed pantothenate kinase-associated neurodegeneration.","volume":"134(Pt 4)","author":"Kruer","year":"2011","journal-title":"Brain"},{"key":"B87","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1002\/ana.22122","article-title":"Defective FA2H leads to a novel form of neurodegeneration with brain iron accumulation (NBIA).","volume":"68","author":"Kruer","year":"2010","journal-title":"Ann. Neurol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.gene.2013.11.039","article-title":"C19orf12 mutation leads to a pallido-pyramidal syndrome.","volume":"537","author":"Kruer","year":"2014","journal-title":"Gene"},{"key":"B89","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/mds.22435","article-title":"A novel ferritin light chain gene mutation in a Japanese family with neuroferritinopathy: description of clinical features and implications for genotype-phenotype correlations.","volume":"24","author":"Kubota","year":"2009","journal-title":"Mov. Disord."},{"key":"B90","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1093\/hmg\/ddi005","article-title":"Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia.","volume":"14","author":"Kuo","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"B91","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/B978-0-12-410502-7.00003-X","article-title":"Pantothenate kinase-associated neurodegeneration (PKAN) and PLA2G6-associated neurodegeneration (PLAN): review of two major neurodegeneration with brain iron accumulation (NBIA) phenotypes.","volume":"110","author":"Kurian","year":"2013","journal-title":"Int. Rev. Neurobiol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1212\/01.wnl.0000310986.48286.8e","article-title":"Phenotypic spectrum of neurodegeneration associated with mutations in the PLA2G6 gene (PLAN).","volume":"70","author":"Kurian","year":"2008","journal-title":"aNeurology"},{"key":"B93","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.parkreldis.2011.06.024","article-title":"Long-term improvement under deferiprone in a case of neurodegeneration with brain iron accumulation.","volume":"18","author":"Kwiatkowski","year":"2012","journal-title":"Parkinsonism Relat. Disord."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1002\/humu.22378","article-title":"Hereditary spastic paraplegia type 43 (SPG43) is caused by mutation in C19orf12.","volume":"34","author":"Landour\u00c3\u00a9","year":"2013","journal-title":"Hum. Mutat."},{"key":"B95","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1074\/jbc.273.1.207","article-title":"Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity.","volume":"273","author":"Larsson","year":"1998","journal-title":"J. Biol. Chem."},{"key":"B96","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/349541a0","article-title":"Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts.","volume":"349","author":"Lawson","year":"1991","journal-title":"Nature"},{"key":"B97","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.parkreldis.2012.06.021","article-title":"Neuroferritinopathy","volume":"18","author":"Lehn","year":"2012","journal-title":"Parkinsonism Relat. Disord."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1073\/pnas.0607621104","article-title":"Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine.","volume":"104","author":"Leonardi","year":"2007a","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B99","doi-asserted-by":"publisher","first-page":"4639","DOI":"10.1016\/j.febslet.2007.08.056","article-title":"Localization and regulation of mouse pantothenate kinase 2.","volume":"581","author":"Leonardi","year":"2007b","journal-title":"FEBS Lett."},{"key":"B100","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.plipres.2005.04.001","article-title":"Coenzyme A: back in action.","volume":"44","author":"Leonardi","year":"2005","journal-title":"Prog. Lipid Res."},{"key":"B101","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1006\/jmbi.1994.1325","article-title":"The role of the L-chain in ferritin iron incorporation. Studies of homo and heteropolymers","volume":"238","author":"Levi","year":"1994","journal-title":"J. Mol. Biol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.devcel.2011.06.024","article-title":"The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes.","volume":"21","author":"Lu","year":"2011","journal-title":"Dev. Cell"},{"key":"B103","doi-asserted-by":"publisher","first-page":"11948","DOI":"10.1074\/jbc.M109.096404","article-title":"Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation.","volume":"285","author":"Luscieti","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B104","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1212\/01.wnl.0000178224.81169.c2","article-title":"Neuroferritinopathy: missense mutation in FTL causing early-onset bilateral pallidal involvement.","volume":"65","author":"Maciel","year":"2005","journal-title":"Neurology"},{"key":"B105","doi-asserted-by":"publisher","first-page":"406","DOI":"10.2353\/ajpath.2008.070823","article-title":"Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations.","volume":"172","author":"Malik","year":"2008","journal-title":"Am. J. Pathol."},{"key":"B106","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/jnen\/64.4.280","article-title":"Hereditary ferritinopathy: a novel mutation, its cellular pathology, and pathogenetic insights.","volume":"64","author":"Mancuso","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1136\/gut.2003.030429","article-title":"Iron chelation therapy in aceruloplasminaemia: study of a patient with a novel missense mutation.","volume":"53","author":"Mariani","year":"2004","journal-title":"Gut"},{"key":"B108","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1212\/01.wnl.0000310985.40011.d6","article-title":"T2* and FSE MRI distinguishes four subtypes of neurodegeneration with brain iron accumulation.","volume":"70","author":"McNeill","year":"2008","journal-title":"Neurology"},{"key":"B109","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1046\/j.1440-1789.2003.00521.x","article-title":"Aceruloplasminemia, an iron metabolic disorder.","volume":"23","author":"Miyajima","year":"2003","journal-title":"Neuropathology"},{"key":"B110","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1212\/WNL.37.5.761","article-title":"Familial apoceruloplasmin deficiency associated with blepharospasm and retinal degeneration.","volume":"37","author":"Miyajima","year":"1987","journal-title":"aNeurology"},{"key":"B111","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1038\/ng1826","article-title":"PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron.","volume":"38","author":"Morgan","year":"2006","journal-title":"Nat. Genet."},{"key":"B112","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1002\/ana.410370515","article-title":"Hereditary ceruloplasmin deficiency with hemosiderosis: a clinicopathological study of a Japanese family.","volume":"37","author":"Morita","year":"1995","journal-title":"Ann. Neurol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.bbadis.2010.10.010","article-title":"Iron loading-induced aggregation and reduction of iron incorporation in heteropolymeric ferritin containing a mutant light chain that causes neurodegeneration.","volume":"1812","author":"Muhoberac","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"B114","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s004010000224","article-title":"Alpha-synuclein accumulation in a case of neurodegeneration with brain iron accumulation type 1 (NBIA-1, formerly Hallervorden\u00e2\u20ac\u201cSpatz syndrome) with widespread cortical and brainstem-type Lewy bodies.","volume":"100","author":"Neumann","year":"2000","journal-title":"Acta Neuropathol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.2169\/internalmedicine.50.5108","article-title":"Criteria for early identification of aceruloplasminemia.","volume":"50","author":"Ogimoto","year":"2011","journal-title":"Intern. Med."},{"issue":"197438","key":"B116","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/197438","article-title":"MRI findings in neuroferritinopathy.","volume":"2012","author":"Ohta","year":"2012","journal-title":"Neurol. Res. Int."},{"key":"B117","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1212\/01.wnl.0000310428.74624.95","article-title":"Neuroferritinopathy in a Japanese family with a duplication in the ferritin light chain gene.","volume":"70(16 Pt 2)","author":"Ohta","year":"2008","journal-title":"Neurology"},{"key":"B118","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.neurobiolaging.2010.05.009","article-title":"Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations.","volume":"33","author":"Pais\u00c3\u00a1n-Ruiz","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"146","key":"B119","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00146","article-title":"A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis.","volume":"7","author":"Pandey","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.spen.2012.03.006","article-title":"C19orf12 and FA2H mutations are rare in Italian patients with neurodegeneration with brain iron accumulation.","volume":"19","author":"Panteghini","year":"2012","journal-title":"Semin. Pediatr. Neurol."},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt623","article-title":"Parkinson\u00e2\u20ac\u2122s disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction.","author":"Park","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"B122","doi-asserted-by":"publisher","first-page":"4305","DOI":"10.1074\/jbc.275.6.4305","article-title":"Alternative RNA splicing generates a glycosylphosphatidylinositol-anchored form of ceruloplasmin in mammalian brain.","volume":"275","author":"Patel","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B123","doi-asserted-by":"crossref","first-page":"6578","DOI":"10.1523\/JNEUROSCI.22-15-06578.2002","article-title":"Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury.","volume":"22","author":"Patel","year":"2002","journal-title":"J.Neurosci."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1074\/jbc.M112.428938","article-title":"Loss of cardiolipin leads to perturbation of mitochondrial and cellular iron homeostasis.","volume":"288","author":"Patil","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B125","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.4049\/jimmunol.176.4.2555","article-title":"Involvement of group VIA calcium-independent phospholipase A2 in macrophage engulfment of hydrogen peroxide-treated U937 cells.","volume":"176","author":"P\u00c3\u00a9rez","year":"2006","journal-title":"J. Immunol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1002\/ana.410180411","article-title":"Hallervorden\u00e2\u20ac\u201cSpatz disease: cysteine accumulation and cysteine dioxygenase deficiency in the globus pallidus.","volume":"18","author":"Perry","year":"1985","journal-title":"Ann. Neurol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.nbd.2010.04.009","article-title":"Pantothenate kinase-2 (Pank2) silencing causes cell growth reduction, cell-specific ferroportin upregulation and iron deregulation.","volume":"39","author":"Poli","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"B128","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.gene.2010.06.011","article-title":"Characterization of the human PANK2 promoter.","volume":"465","author":"Polster","year":"2010","journal-title":"Gene"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1002\/glia.21172","article-title":"Central nervous system dysfunction in a mouse model of FA2H deficiency.","volume":"59","author":"Potter","year":"2011","journal-title":"Glia"},{"key":"B130","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1093\/hmg\/ddr606","article-title":"PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity.","volume":"21","author":"Ramonet","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B131","doi-asserted-by":"publisher","first-page":"6988","DOI":"10.1073\/pnas.0912105107","article-title":"Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration.","volume":"107","author":"Rana","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B132","doi-asserted-by":"publisher","first-page":"389","DOI":"10.5581\/1516-8484.20110104","article-title":"Aceruloplasminemia: a rare disease \u00e2\u20ac\u201c diagnosis and treatment of two cases.","volume":"33","author":"Roberti Mdo","year":"2011","journal-title":"Rev. Bras. Hematol. Hemoter."},{"key":"B133","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1242\/dmm.009019","article-title":"Biogenesis of iron\u00e2\u20ac\u201csulfur clusters in mammalian cells: new insights and relevance to human disease.","volume":"5","author":"Rouault","year":"2012","journal-title":"Dis. Model. Mech."},{"key":"B134","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nrn3453","article-title":"Iron metabolism in the CNS: implications for neurodegenerative diseases.","volume":"14","author":"Rouault","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"B135","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/ng.2562","article-title":"De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood.","volume":"45","author":"Saitsu","year":"2013","journal-title":"Nat. Genet."},{"key":"B136","doi-asserted-by":"crossref","first-page":"12744","DOI":"10.1016\/S0021-9258(18)31451-0","article-title":"Production and characterization of recombinant heteropolymers of human ferritin H and L chains.","volume":"268","author":"Santambrogio","year":"1993","journal-title":"J. Biol. Chem."},{"key":"B137","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1002\/mds.22947","article-title":"ATP13A2 mutations (PARK9) cause neurodegeneration with brain iron accumulation.","volume":"25","author":"Schneider","year":"2010","journal-title":"Mov. Disord."},{"key":"B138","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1007\/s11940-013-0254-5","article-title":"Pathophysiology and treatment of neurodegeneration with brain iron accumulation in the pediatric population","volume":"15","author":"Schneider","year":"2013","journal-title":"Curr. Treat. Options Neurol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1093\/hmg\/ddt057","article-title":"Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited \u00ce\u00b1-synuclein accumulation and age-dependent sensorimotor deficits.","volume":"22","author":"Schultheis","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"B140","doi-asserted-by":"publisher","first-page":"13301","DOI":"10.1523\/JNEUROSCI.2838-11.2011","article-title":"Iron efflux from oligodendrocytes is differentially regulated in gray and white matter.","volume":"31","author":"Schulz","year":"2011","journal-title":"J. Neurosci."},{"key":"B141","doi-asserted-by":"publisher","first-page":"22275","DOI":"10.1074\/jbc.M604330200","article-title":"Calcium-independent phospholipase A2 localizes in and protects mitochondria during apoptotic induction by staurosporine.","volume":"281","author":"Seleznev","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B142","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1002\/ana.410240519","article-title":"Hallervorden\u00e2\u20ac\u201cSpatz syndrome: clinical and magnetic resonance imaging correlations.","volume":"24","author":"Sethi","year":"1988","journal-title":"Ann. Neurol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1523\/JNEUROSCI.4354-07.2008","article-title":"Neuroaxonal dystrophy caused by group VIA phospholipase A2 deficiency in mice: a model of human neurodegenerative disease.","volume":"28","author":"Shinzawa","year":"2008","journal-title":"J. Neurosci."},{"key":"B144","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1083\/jcb.200306159","article-title":"PLA2 activity is required for nuclear shrinkage in caspase-independent cell death.","volume":"163","author":"Shinzawa","year":"2003","journal-title":"J. Cell Biol."},{"issue":"e43145","key":"B145","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043145","article-title":"Cofilin\/twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism.","volume":"7","author":"Siudeja","year":"2012","journal-title":"PLoS ONE"},{"key":"B146","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1002\/emmm.201100180","article-title":"Impaired coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration","volume":"3","author":"Siudeja","year":"2011","journal-title":"EMBO Mol. Med."},{"key":"B147","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1136\/jnnp.2007.120568","article-title":"Aceruloplasminaemia with progressive atrophy without brain iron overload: treatment with oral chelation.","volume":"79","author":"Skidmore","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B148","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/ncb1089","article-title":"A novel mechanism for the store-operated calcium influx pathway.","volume":"6","author":"Smani","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1002\/mds.25275","article-title":"De novo FTL mutation: a clinical, neuroimaging, and molecular study.","volume":"28","author":"Storti","year":"2013","journal-title":"Mov. Disord."},{"key":"B150","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1093\/hmg\/dds108","article-title":"Severe disturbance in the Ca2+ signaling in astrocytes from mouse models of human infantile neuroaxonal dystrophy with mutated Pla2g6.","volume":"21","author":"Strokin","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/S0022-2828(87)80526-6","article-title":"Mitochondrial synthesis of coenzyme A is on the external surface.","volume":"19","author":"Tahiliani","year":"1987","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"29654","DOI":"10.1074\/jbc.M111.233874","article-title":"Regulation of intracellular manganese homeostasis by Kufor\u00e2\u20ac\u201cRakeb syndrome-associated ATP13A2 protein.","volume":"286","author":"Tan","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B153","doi-asserted-by":"publisher","first-page":"8567","DOI":"10.1074\/jbc.272.13.8567","article-title":"A novel cytosolic calcium-independent phospholipase A2 contains eight ankyrin motifs.","volume":"272","author":"Tang","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B154","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1471-4159.2011.07554.x","article-title":"Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and BDNF.","volume":"120","author":"Texel","year":"2012","journal-title":"J. Neurochem."},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt572","article-title":"Zn2+ dyshomeostasis caused by loss of ATP13A2\/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation.","author":"Tsunemi","year":"2013","journal-title":"Hum Mol. Genet."},{"key":"B156","doi-asserted-by":"publisher","first-page":"4240","DOI":"10.1523\/JNEUROSCI.5575-11.2012","article-title":"Deficiency of ATP13A2 leads to lysosomal dysfunction, \u00ce\u00b1-synuclein accumulation, and neurotoxicity.","volume":"32","author":"Usenovic","year":"2012","journal-title":"J. Neurosci."},{"key":"B157","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/jnen\/63.4.363","article-title":"Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene.","volume":"63","author":"Vidal","year":"2004","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1523\/JNEUROSCI.3962-07.2008","article-title":"Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice","volume":"28","author":"Vidal","year":"2008","journal-title":"J. Neurosci."},{"key":"B159","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.2353\/ajpath.2009.090343","article-title":"Establishment of an improved mouse model for infantile neuroaxonal dystrophy that shows early disease onset and bears a point mutation in Pla2g6.","volume":"175","author":"Wada","year":"2009","journal-title":"Am. J. Pathol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s004010050049","article-title":"Juvenile-onset generalized neuroaxonal dystrophy (Hallervorden\u00e2\u20ac\u201cSpatz disease) with diffuse neurofibrillary and Lewy body pathology.","volume":"99","author":"Wakabayashi","year":"2000","journal-title":"Acta Neuropathol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.1111\/j.1460-9568.2007.05515.x","article-title":"Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6-OHDA-lesioned rats.","volume":"25","author":"Wang","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"B162","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1042\/0264-6021:3620023","article-title":"Inhibition of mitochondrial calcium-independent phospholipase A2 (iPLA2) attenuates mitochondrial phospholipid loss and is cardioprotective.","volume":"362(Pt 1)","author":"Williams","year":"2002","journal-title":"Biochem. J."},{"key":"B163","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1136\/jnnp.73.1.91","article-title":"Palatal tremor and cognitive decline in neuroferritinopathy.","volume":"73","author":"Wills","year":"2002","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B164","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/S1388-1981(00)00107-4","article-title":"Calcium-independent phospholipase A(2): structure and function.","volume":"1488","author":"Winstead","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"B165","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1016\/j.ajpath.2011.12.041","article-title":"Ferroxidase hephaestin\u00e2\u20ac\u2122s cell-autonomous role in the retinal pigment epithelium.","volume":"180","author":"Wolkow","year":"2012","journal-title":"Am. J. Pathol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/j.1468-1331.2008.02397.x","article-title":"Clinical study and PLA2G6 mutation screening analysis in Chinese patients with infantile neuroaxonal dystrophy.","volume":"16","author":"Wu","year":"2009a","journal-title":"Eur. J. Neurol."},{"key":"B167","doi-asserted-by":"publisher","first-page":"3659","DOI":"10.1093\/hmg\/ddp314","article-title":"Pantothenate kinase-associated neurodegeneration: insights from a Drosophila model.","volume":"18","author":"Wu","year":"2009b","journal-title":"Hum. Mol. Genet."},{"key":"B168","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0925-4439(02)00165-5","article-title":"Quantitative evaluation of expression of iron-metabolism genes in ceruloplasmin-deficient mice.","volume":"1588","author":"Yamamoto","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"B169","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1006\/abio.1999.4053","article-title":"Group-specific assays that distinguish between the four major types of mammalian phospholipase A2.","volume":"269","author":"Yang","year":"1999","journal-title":"Anal. Biochem."},{"key":"B170","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/ng0395-267","article-title":"A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans.","volume":"9","author":"Yoshida","year":"1995","journal-title":"Nat. Genet."},{"key":"B171","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1242\/jcs.02821","article-title":"Disruption of G1-phase phospholipid turnover by inhibition of Ca2+-independent phospholipase A2 induces a p53-dependent cell-cycle arrest in G1 phase.","volume":"119(Pt 6)","author":"Zhang","year":"2006a","journal-title":"J. Cell Sci."},{"key":"B172","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1074\/jbc.M508825200","article-title":"Biochemical properties of human pantothenate kinase 2 isoforms and mutations linked to pantothenate kinase-associated neurodegeneration.","volume":"281","author":"Zhang","year":"2006b","journal-title":"J. Biol. Chem."},{"key":"B173","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/ng572","article-title":"A novel pantothenate kinase gene (PANK2) is defective in Hallervorden\u00e2\u20ac\u201cSpatz syndrome.","volume":"28","author":"Zhou","year":"2001","journal-title":"Nat. Genet."},{"key":"B174","doi-asserted-by":"publisher","first-page":"22107","DOI":"10.1074\/jbc.C200195200","article-title":"Molecular cloning of CoA synthase. The missing link in CoA biosynthesis.","volume":"277","author":"Zhyvoloup","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B175","doi-asserted-by":"publisher","first-page":"9741","DOI":"10.1523\/JNEUROSCI.0458-08.2008","article-title":"Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration.","volume":"28","author":"Z\u00c3\u00b6ller","year":"2008","journal-title":"J. Neurosci."},{"key":"B176","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1002\/mds.23751","article-title":"Iron-related MRI images in patients with pantothenate kinase-associated neurodegeneration (PKAN) treated with deferiprone: results of a phase II pilot trial.","volume":"26","author":"Zorzi","year":"2011","journal-title":"Mov. Disord."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"deposited":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T06:12:33Z","timestamp":1648966353000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2014.00099\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,7]]},"references-count":176,"URL":"https:\/\/doi.org\/10.3389\/fphar.2014.00099","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,7]]}}}