{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:08:31Z","timestamp":1780632511044,"version":"3.54.1"},"reference-count":116,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2014.00270","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T14:26:54Z","timestamp":1418999214000},"source":"Crossref","is-referenced-by-count":28,"title":["In utero therapy for congenital disorders using amniotic fluid stem cells"],"prefix":"10.3389","volume":"5","author":[{"given":"Durrgah L.","family":"Ramachandra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven S. W.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panicos","family":"Shangaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Loukogeorgakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale V.","family":"Guillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo De","family":"Coppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2014,12,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1056\/NEJM200008033430503","article-title":"Hepatic iron concentration and total body iron stores in thalassemia major","volume":"343","author":"Angelucci","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S0888-7543(03)00107-1","article-title":"Transgenes encompassing dual-promoter CpG islands from the human TBP and HNRPA2B1 loci are resistant to heterochromatin-mediated silencing","volume":"82","author":"Antoniou","year":"2003","journal-title":"Genomics"},{"key":"B3","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.exphem.2005.11.011","article-title":"Busulfan-conditioned bone marrow transplantation results in high-level allogeneic chimerism in mice made tolerant by in utero hematopoietic cell transplantation","volume":"34","author":"Ashizuka","year":"2006","journal-title":"Exp. Hematol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1182\/blood-2002-07-2314","article-title":"Side effects of retroviral gene transfer into hematopoietic stem cells","volume":"101","author":"Baum","year":"2003","journal-title":"Blood"},{"key":"B5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1002\/emmm.201000108","article-title":"Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell","volume":"3","author":"Biasco","year":"2011","journal-title":"EMBO Mol. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1182\/blood-2011-09-377630","article-title":"AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage","volume":"119","author":"Binny","year":"2012","journal-title":"Blood"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1093\/humrep\/den302","article-title":"First trimester embryo-fetoscopic and ultrasound-guided fetal blood sampling for ex vivo viral transduction of cultured human fetal mesenchymal stem cells","volume":"23","author":"Chan","year":"2008","journal-title":"Hum. Reprod."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.siny.2013.09.004","article-title":"Fetal surgery for neural tube defects","volume":"19","author":"Danzer","year":"2014","journal-title":"Semin. Fetal Neonatal Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1469-8749.2011.04049.x","article-title":"Fetal surgery for myelomeningocele: progress and perspectives","volume":"54","author":"Danzer","year":"2012","journal-title":"Dev. Med. Child Neurol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"4715","DOI":"10.1182\/blood-2004-10-4051","article-title":"Ontogeny of CD4+CD25+ regulatory\/suppressor T cells in human fetuses","volume":"105","author":"Darrasse-J\u00c3\u00a8ze","year":"2005","journal-title":"Blood"},{"key":"B11","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1089\/hum.2010.007","article-title":"Recombinant adeno-associated virus-mediated in utero gene transfer gives therapeutic transgene expression in the sheep","volume":"22","author":"David","year":"2011","journal-title":"Hum. Gene Ther."},{"key":"B12","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.bpobgyn.2007.08.008","article-title":"Gene therapy for the fetus: is there a future?","volume":"22","author":"David","year":"2008","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"B13","first-page":"181","article-title":"The current status and future direction of fetal gene therapy","volume":"7","author":"David","year":"2003","journal-title":"Gene Ther. Mol. Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/978-1-61779-873-3_2","article-title":"Candidate diseases for prenatal gene therapy","volume":"891","author":"David","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1159\/000072456","article-title":"Gene transfer strategies for correction of lysosomal storage disorders","volume":"110","author":"D\u00e2\u20ac\u2122Azzo","year":"2003","journal-title":"Acta Haematol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jpedsurg.2012.11.005","article-title":"Regenerative medicine for congenital malformations","volume":"48","author":"De Coppi","year":"2013","journal-title":"J. Pediatr. Surg."},{"key":"B17","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/nbt1274","article-title":"Isolation of amniotic stem cell lines with potential for therapy","volume":"25","author":"De Coppi","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/S0076-6879(06)19017-5","article-title":"Amniotic fluid and placental stem cells","volume":"419","author":"Delo","year":"2006","journal-title":"Methods Enzymol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1089\/10430340252898984","article-title":"High-level transduction and gene expression in hematopoietic repopulating cells using a human immunodeficiency virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter","volume":"13","author":"Demaison","year":"2002","journal-title":"Hum. Gene Ther."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3953","DOI":"10.1182\/blood-2008-10-182105","article-title":"Human and murine amniotic fluid c-kit+Lin-cells display hematopoietic activity","volume":"113","author":"Ditadi","year":"2009","journal-title":"Blood"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2014.0234","article-title":"Immune regulatory properties of cd117(pos) amniotic fluid stem cells vary according to gestational age","author":"Di Trapani","year":"2014","journal-title":"Stem Cells Dev."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1517\/14712598.2013.849690","article-title":"Stem cells as a potential therapy for necrotizing enterocolitis","volume":"13","author":"Eaton","year":"2013","journal-title":"Expert Opin. Biol. Ther."},{"key":"B23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1017\/CBO9780511550089.051","article-title":"\u00e2\u20ac\u0153Report on the potential use of gene therapy in utero,\u00e2\u20ac\u009d","volume-title":"Manual for Research Ethics Committees: Centre of Medical Law and Ethics, King\u00e2\u20ac\u2122s College London","author":"Eckstein","year":"2003","edition":"ed."},{"key":"B24","volume-title":"Committee for the Medicinal Products for Human Use (CHMP). Guideline on Non-Clinical Testing for Inadvertent Germline Transmission of Gene Transfer Vectors","author":"EU.","year":"2006"},{"key":"B25","volume-title":"Guideline on Human Cell-Based Medicinal Products. Draft Committee for Human Medicinal Product (CHMP)","author":"European Medicines Agency.","year":"2007"},{"key":"B26","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1262\/jrd.2011-046","article-title":"Generation of human \u00ce\u00b2-thalassemia induced pluripotent stem cells from amniotic fluid cells using a single excisable lentiviral stem cell cassette","volume":"58","author":"Fan","year":"2012","journal-title":"J. Reprod. Dev."},{"key":"B27","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.bpobgyn.2004.07.001","article-title":"Amniotic fluid and placental stem cells","volume":"18","author":"Fauza","year":"2004","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.bpobgyn.2004.06.006","article-title":"In utero stem cell transplantation","volume":"18","author":"Flake","year":"2004","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1056\/NEJM199612123352404","article-title":"Treatment of X-linked severe combined immunodeficiency by in utero transplantation of paternal bone marrow","volume":"335","author":"Flake","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/0168-9525(93)90015-A","article-title":"From white spots to stem cells: the role of the kit receptor in mammalian development","volume":"9","author":"Fleischman","year":"1993","journal-title":"Trends Genet."},{"key":"B31","doi-asserted-by":"publisher","first-page":"97ra80","DOI":"10.1126\/scitranslmed.3002716","article-title":"Hematopoietic stem cell gene therapy for adenosine deaminase-deficient severe combined immunodeficiency leads to long-term immunological recovery and metabolic correction","volume":"3","author":"Gaspar","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1517\/14712598.5.9.1175","article-title":"Gene therapy for severe combined immunodeficiencies","volume":"5","author":"Gaspar","year":"2005","journal-title":"Expert Opin. Biol. Ther."},{"key":"B33","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00383-009-2504-x","article-title":"Amniotic fluid stem cell migration after intraperitoneal injection in pup rats: implication for therapy","volume":"26","author":"Ghionzoli","year":"2010","journal-title":"Pediatr. Surg. Int."},{"key":"B34","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1093\/oxfordjournals.bmb.a071847","article-title":"Amniotic fluid cell types and culture","volume":"39","author":"Gosden","year":"1983","journal-title":"Br. Med. Bull."},{"key":"B35","doi-asserted-by":"publisher","first-page":"255","DOI":"10.5966\/sctm.2013-0090","article-title":"Pre- and postnatal transplantation of fetal mesenchymal stem cells in osteogenesis imperfecta: a two-center experience","volume":"3","author":"G\u00c3\u00b6therstr\u00c3\u00b6m","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1089\/scd.2007.0188","article-title":"High transduction efficiency of human amniotic fluid stem cells mediated by adenovirus vectors","volume":"17","author":"Grisafi","year":"2008","journal-title":"Stem Cells Dev."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1182\/blood-2007-08-105809","article-title":"Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice","volume":"111","author":"Guillot","year":"2008","journal-title":"Blood"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1750-1172-5-13","article-title":"Alpha-thalassaemia","volume":"5","author":"Harteveld","year":"2010","journal-title":"Orphanet. J. Rare Dis."},{"key":"B39","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.exphem.2003.12.008","article-title":"Complete allogeneic hematopoietic chimerism achieved by in utero hematopoietic cell transplantation and cotransplantation of LLME-treated, MHC-sensitized donor lympho,cytes","volume":"32","author":"Hayashi","year":"2004","journal-title":"Exp. Hematol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"8932","DOI":"10.1073\/pnas.132252399","article-title":"Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone","volume":"99","author":"Horwitz","year":"2002","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"B41","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1172\/JCI35798","article-title":"Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients","volume":"118","author":"Howe","year":"2008","journal-title":"J. Clin. Invest."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3889","DOI":"10.1172\/JCI68989","article-title":"Differentiation and functional regulation of human fetal NK cells","volume":"123","author":"Ivarsson","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B43","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1089\/scd.2013.0132","article-title":"Potential of human fetal chorionic stem cells for the treatment of osteogenesis imperfecta","volume":"23","author":"Jones","year":"2014","journal-title":"Stem Cells Dev."},{"key":"B44","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/S1072-7515(02)01834-3","article-title":"Fetal tissue engineering from amniotic fluid","volume":"196","author":"Kaviani","year":"2003","journal-title":"J. Am. Coll. Surg."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1053\/jpsu.2001.27945","article-title":"The amniotic fluid as a source of cells for fetal tissue engineering","volume":"36","author":"Kaviani","year":"2001","journal-title":"J. Pediatr. Surg."},{"key":"B46","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/73464","article-title":"Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector","volume":"24","author":"Kay","year":"2000","journal-title":"Nat. Genet."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1097\/01.TP.0000159029.48678.93","article-title":"Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta","volume":"79","author":"Le Blanc","year":"2005","journal-title":"Transplantation"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1111\/j.1582-4934.2011.01470.x","article-title":"Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta","volume":"16","author":"Li","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1086\/301800","article-title":"Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis","volume":"62","author":"Lo","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"B51","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.yexcr.2012.09.017","article-title":"Modeling neurogenesis impairment in Down syndrome with induced pluripotent stem cells from trisomy 21 amniotic fluid cells","volume":"319","author":"Lu","year":"2012","journal-title":"Exp. Cell Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1054\/blre.2002.0192","article-title":"The cure of thalassemia by bone marrow transplantation","volume":"16","author":"Lucarelli","year":"2002","journal-title":"Blood Rev."},{"key":"B53","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1006\/bcmd.2001.0424","article-title":"Human mesenchymal stem cells persist, demonstrate site-specific multipotential differentiation, and are present in sites of wound healing and tissue regeneration after transplantation into fetal sheep","volume":"27","author":"Mackenzie","year":"2001","journal-title":"Blood Cells Mol. Dis."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.1182\/blood-2002-10-3296","article-title":"AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B","volume":"101","author":"Manno","year":"2003","journal-title":"Blood"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1038\/mt.2011.107","article-title":"Stable human FIX expression after 0.9G intrauterine gene transfer of self-complementary adeno-associated viral vector 5 and 8 in macaques","volume":"19","author":"Mattar","year":"2011","journal-title":"Mol. Ther."},{"key":"B56","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1086\/381053","article-title":"The burden of genetic disease on inpatient care in a children\u00e2\u20ac\u2122s hospital","volume":"74","author":"McCandless","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"B57","doi-asserted-by":"publisher","first-page":"3335","DOI":"10.1182\/blood-2012-10-462200","article-title":"Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant","volume":"121","author":"McIntosh","year":"2013","journal-title":"Blood"},{"key":"B58","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/978-1-61779-873-3_14","article-title":"Monitoring for potential adverse effects of prenatal gene therapy: use of large animal models with relevance to human application","volume":"891","author":"Mehta","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1002\/pd.2787","article-title":"Organ targeted prenatal gene therapy\u00e2\u20ac\u201dhow far are we?","volume":"31","author":"Mehta","year":"2011","journal-title":"Prenat. Diagn."},{"key":"B60","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/978-1-61779-873-3_9","article-title":"Animal models for prenatal gene therapy: choosing the right model","volume":"891","author":"Mehta","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"B61","first-page":"1","article-title":"Sickle cell disease","volume":"2011","author":"Meremikwu","year":"2011","journal-title":"Clin. Evid."},{"key":"B62","doi-asserted-by":"publisher","first-page":"480","DOI":"10.2471\/BLT.06.036673","article-title":"Global epidemiology of haemoglobin disorders and derived service indicators","volume":"86","author":"Modell","year":"2008","journal-title":"Bull. World Health Organ."},{"key":"B63","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/B978-0-12-394299-9.00003-5","article-title":"Immunological tolerance during fetal development: from mouse to man","volume":"115","author":"Mold","year":"2012","journal-title":"Adv. Immunol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2174\/156652312799789253","article-title":"Gene therapy for severe combined immunodeficiency due to adenosine deaminase deficiency","volume":"12","author":"Montiel-Equihua","year":"2012","journal-title":"Curr. Gene Ther."},{"key":"B65","doi-asserted-by":"publisher","first-page":"e26535","DOI":"10.1371\/journal.pone.0026535","article-title":"Cloned, CD117 selected human amniotic fluid stem cells are capable of modulating the immune response","volume":"6","author":"Moorefield","year":"2011","journal-title":"PLoS ONE"},{"key":"B66","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/scd.2010.0483","article-title":"Fetal liver-derived mesenchymal stem cell engraftment after allogeneic in utero transplantation into rabbits","volume":"21","author":"Moreno","year":"2012","journal-title":"Stem Cells Dev."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1038\/mt.2012.117","article-title":"Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach","volume":"20","author":"Moschidou","year":"2012","journal-title":"Mol. Ther."},{"key":"B68","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1089\/scd.2012.0267","article-title":"Human mid-trimester amniotic fluid stem cells cultured under embryonic stem cell conditions with valproic acid acquire pluripotent characteristics","volume":"22","author":"Moschidou","year":"2013","journal-title":"Stem Cells Dev."},{"key":"B69","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/sj.bmt.1704811","article-title":"In utero transplantation: baby steps towards an effective therapy","volume":"35","author":"Muench","year":"2005","journal-title":"Bone Marrow Transpl."},{"key":"B70","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1080\/14653240701656061","article-title":"Comparative analysis of mesenchymal stromal cells from murine bone marrow and amniotic fluid","volume":"9","author":"Nadri","year":"2007","journal-title":"Cytotherapy"},{"key":"B71","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.1182\/blood-2005-10-4035","article-title":"Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver","volume":"107","author":"Nathwani","year":"2006","journal-title":"Blood"},{"key":"B72","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1056\/NEJMoa1108046","article-title":"Adenovirus-associated virus vector-mediated gene transfer in hemophilia B","volume":"365","author":"Nathwani","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"4595","DOI":"10.1182\/blood-2012-10-463174","article-title":"Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice","volume":"121","author":"Nijagal","year":"2013","journal-title":"Blood"},{"key":"B74","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.clp.2012.04.004","article-title":"In utero hematopoietic cell transplantation for the treatment of congenital anomalies","volume":"39","author":"Nijagal","year":"2012","journal-title":"Clin. Perinatol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1172\/JCI44907","article-title":"Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice","volume":"121","author":"Nijagal","year":"2011","journal-title":"J. Clin. Invest."},{"key":"B76","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.bpobgyn.2004.06.010","article-title":"Fetal stem cells","volume":"18","author":"O\u00e2\u20ac\u2122Donoghue","year":"2004","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1067\/mob.2000.106976","article-title":"Normal development of human fetal hematopoiesis between eight and seventeen weeks\u00e2\u20ac\u2122 gestation","volume":"183","author":"Pahal","year":"2000","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1126\/science.1065806","article-title":"Correction of sickle cell disease in transgenic mouse models by gene therapy","volume":"294","author":"Pawliuk","year":"2001","journal-title":"Science"},{"key":"B79","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1053\/j.sempedsurg.2012.10.010","article-title":"Stem cell and genetic therapies for the fetus","volume":"22","author":"Pearson","year":"2013","journal-title":"Semin. Pediatr. Surg."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1182\/blood-2006-04-018606","article-title":"Evidence for an immune barrier after in utero hematopoietic-cell transplantation","volume":"109","author":"Peranteau","year":"2007","journal-title":"Blood"},{"key":"B81","doi-asserted-by":"publisher","first-page":"4268","DOI":"10.1182\/blood-2006-04-018986","article-title":"CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation","volume":"108","author":"Peranteau","year":"2006","journal-title":"Blood"},{"key":"B82","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1182\/blood-2002-01-0166","article-title":"High-level allogeneic chimerism achieved by prenatal tolerance induction and postnatal nonmyeloablative bone marrow transplantation","volume":"100","author":"Peranteau","year":"2002","journal-title":"Blood"},{"key":"B83","doi-asserted-by":"publisher","first-page":"e9357","DOI":"10.1371\/journal.pone.0009357","article-title":"Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis","volume":"5","author":"Perin","year":"2010","journal-title":"PLoS ONE"},{"key":"B84","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1182\/blood-2003-03-0677","article-title":"Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells","volume":"102","author":"Persons","year":"2003","journal-title":"Blood"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1084\/jem.175.4.1055","article-title":"Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon, delta proteins","volume":"175","author":"Phillips","year":"1992","journal-title":"J. Exp. Med."},{"key":"B86","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1089\/cell.2013.0091","article-title":"Trisomy 21 mid-trimester amniotic fluid induced pluripotent stem cells maintain genetic signatures during reprogramming: implications for disease modeling and cryobanking","volume":"16","author":"Pipino","year":"2014","journal-title":"Cell. Reprogram."},{"key":"B87","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/bmb\/lds033","article-title":"Placenta as a reservoir of stem cells: an underutilized resource?","volume":"105","author":"Pipino","year":"2013","journal-title":"Br. Med. Bull."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1016\/j.exphem.2008.09.003","article-title":"Development and characterization of a novel CD34 monoclonal antibody that identifies sheep hematopoietic stem\/progenitor cells","volume":"36","author":"Porada","year":"2008","journal-title":"Exp. Hematol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/j.exphem.2011.09.001","article-title":"Phenotypic correction of hemophilia A in sheep by postnatal intraperitoneal transplantation of FVIII-expressing MSC","volume":"39","author":"Porada","year":"2011","journal-title":"Exp. Hematol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1093\/humrep\/deg279","article-title":"Amniotic fluid cells and human stem cell research: a new connection","volume":"8","author":"Prusa","year":"2002","journal-title":"Signature"},{"key":"B91","doi-asserted-by":"publisher","first-page":"3445","DOI":"10.1182\/blood-2004-04-1427","article-title":"Successful correction of the human beta-thalassemia major phenotype using a lentiviral vector","volume":"104","author":"Puthenveetil","year":"2004","journal-title":"Blood"},{"key":"B92","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1089\/10430340050015257","article-title":"Regulatory issues: prenatal gene transfer: scientific, medical, and ethical issues. A report of the Recombinant DNA Advisory Committee","volume":"11","author":"RAC.","year":"2000","journal-title":"Hum. Gene Ther."},{"key":"B93","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1089\/scd.2007.0036","article-title":"Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid: comparison to bone marrow mesenchymal stem cells","volume":"16","author":"Roubelakis","year":"2007","journal-title":"Stem Cells Dev."},{"key":"B94","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.siny.2009.05.005","article-title":"Stem cell and genetic therapies for the fetus","volume":"15","author":"Roybal","year":"2010","journal-title":"Semin. Fetal Neonatal Med."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/j.ajog.2004.06.042","article-title":"In utero transplantation of autologous and allogeneic fetal liver stem cells in ovine fetuses","volume":"191","author":"Schoeberlein","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1839","article-title":"Sheep CD34+ amniotic fluid cells have haematopoietic potential and engraft after autologous in utero transplantation","author":"Shaw","year":"2014","journal-title":"Stem Cells."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.3727\/096368910X543402","article-title":"Autologous transplantation of amniotic fluid-derived mesenchymal stem cells into sheep fetuses","volume":"20","author":"Shaw","year":"2011","journal-title":"Cell Transplant."},{"key":"B98","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1097\/GCO.0b013e32834457b1","article-title":"Clinical applications of prenatal and postnatal therapy using stem cells retrieved from amniotic fluid","volume":"23","author":"Shaw","year":"2011","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/nri1781","article-title":"Journey through the thymus: stromal guides for T-cell development and selection","volume":"6","author":"Takahama","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1387\/ijdb.041957mt","article-title":"Embryonic development of the human hematopoietic system","volume":"49","author":"Tavian","year":"2005","journal-title":"Int. J. Dev. Biol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/sj.mt.6300393","article-title":"Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency","volume":"16","author":"Thornhill","year":"2008","journal-title":"Mol. Ther."},{"key":"B102","doi-asserted-by":"publisher","first-page":"E5","DOI":"10.1038\/nature05219","article-title":"Gene therapy: X-SCID transgene leukaemogenicity","volume":"443","author":"Thrasher","year":"2006","journal-title":"Nature"},{"key":"B103","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.bpobgyn.2007.07.007","article-title":"Fetal stem-cell transplantation","volume":"22","author":"Tiblad","year":"2008","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1095\/biolreprod.105.046029","article-title":"Clonal amniotic fluid-derived stem cells express characteristics of both","volume":"191","author":"Tsai","year":"2004","journal-title":"Am. J. Obstet. Gnecol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1159\/000083900","article-title":"Heterogeneity in fetal immunocompetence during the second trimester of gestation: implications for treatment of nonimmune genetic disorders by in utero transplantation","volume":"20","author":"Tse","year":"2005","journal-title":"Fetal Diagn. Ther."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1182\/blood-2013-11-537571","article-title":"Stable long-term mixed hematopoietic chimerism achieved in a canine model of allogeneic in utero hematopoietic cell transplantation","volume":"124","author":"Vrecenak","year":"2014","journal-title":"Blood"},{"key":"B107","first-page":"432","article-title":"Fetal gene transfer","volume":"9","author":"Waddington","year":"2007","journal-title":"Curr. Opin. Mol. Ther."},{"issue":"Suppl. 1","key":"B108","doi-asserted-by":"publisher","first-page":"S92","DOI":"10.1038\/sj.gt.3302375","article-title":"Fetal and neonatal gene therapy: benefits and pitfalls","volume":"11","author":"Waddington","year":"2004a","journal-title":"Gene Ther."},{"key":"B109","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1182\/blood-2004-02-0627","article-title":"Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy","volume":"104","author":"Waddington","year":"2004b","journal-title":"Blood"},{"key":"B110","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1055\/s-2006-952156","article-title":"In utero stem cell transplantation","volume":"24","author":"Westgren","year":"2006","journal-title":"Semin. Reprod. Med."},{"key":"B111","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1067\/mob.2002.123602","article-title":"Prenatal T-cell reconstitution after in utero transplantation with fetal liver cells in a patient with X-linked severe combined immunodeficiency","volume":"187","author":"Westgren","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1097\/00007890-199604270-00010","article-title":"Lack of evidence of permanent engraftment after in utero fetal stem cell transplantation in congenital hemoglobinopathies","volume":"61","author":"Westgren","year":"1996","journal-title":"Transplantation"},{"key":"B113","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1472-6750-5-17","article-title":"CpG-island fragments from the HNRPA2B1\/CBX3 genomic locus reduce silencing and enhance transgene expression from the hCMV promoter\/enhancer in mammalian cells","volume":"5","author":"Williams","year":"2005","journal-title":"BMC Biotechnol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/nm1365","article-title":"Effective gene therapy with nonintegrating lentiviral vectors","volume":"12","author":"Y\u00c3\u00a1\u00c3\u00b1ez-Mu\u00c3\u00b1oz","year":"2006","journal-title":"Nat. Med."},{"key":"B115","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1136\/gutjnl-2012-303735","article-title":"Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism","volume":"63","author":"Zani","year":"2014","journal-title":"Gut"},{"key":"B116","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1182\/blood-2006-12-060814","article-title":"Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells","volume":"110","author":"Zhang","year":"2007","journal-title":"Blood"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"deposited":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T16:31:45Z","timestamp":1566145905000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphar.2014.00270\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,19]]},"references-count":116,"URL":"https:\/\/doi.org\/10.3389\/fphar.2014.00270","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,19]]}}}