{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:39:16Z","timestamp":1788388756634,"version":"build-2803163510"},"reference-count":30,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2015.00052","type":"journal-article","created":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T09:26:57Z","timestamp":1427102817000},"source":"Crossref","is-referenced-by-count":17,"title":["Genetic determinants for methotrexate response in juvenile idiopathic arthritis"],"prefix":"10.3389","volume":"6","author":[{"given":"Serena","family":"Pastore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Stocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Favretto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"De Iudicibus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Taddio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pio","family":"d\u00e2\u20ac\u2122Adamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Malus\u00c3\u00a0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Addobbati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Decorti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Lepore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Ventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,3,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/clpt.2011.293","article-title":"Optimization of pediatric rheumatology therapeutics.","volume":"91","author":"Becker","year":"2011","journal-title":"Clin. Pharmacol. Ther."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205351","article-title":"Efficacy and safety of tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase 3 randomised, double-blind withdrawal trial.","author":"Brunner","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1136\/annrheumdis-2013-203723","article-title":"Methotrexate polyglutamates in erythrocytes are associated with lower disease activity in juvenile idiopathic arthritis patients.","volume":"74","author":"\u00c4\u2020alasan","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nrrheum.2010.5","article-title":"Methotrexate\u00e2\u20ac\u201chow does it really work?","volume":"6","author":"Chan","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/tpj.2014.3","article-title":"Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.","volume":"14","author":"Cobb","year":"2014","journal-title":"Pharmacogenomics. J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1124\/pr.57.2.3","article-title":"Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis.","volume":"57","author":"Cronstein","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1073\/pnas.88.6.2441","article-title":"Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells.","volume":"88","author":"Cronstein","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/FPC.0b013e32834d3e0b","article-title":"Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis.","volume":"22","author":"Dervieux","year":"2011","journal-title":"Pharmacogenet. Genomics"},{"key":"B9","doi-asserted-by":"publisher","first-page":"4512","DOI":"10.1182\/blood-2008-07-172106","article-title":"Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.","volume":"113","author":"French","year":"2009","journal-title":"Blood"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1056\/NEJM199204163261602","article-title":"Methotrexate in resistant juvenile rheumatoid arthritis. results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. the pediatric rheumatology collaborative study group and the cooperative children\u00e2\u20ac\u2122s study group.","volume":"326","author":"Giannini","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1136\/ard.2010.146191","article-title":"Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis.","volume":"70","author":"Hinks","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1136\/ard.2007.087593","article-title":"Safety and efficacy of combination of etanercept and methotrexate compared to treatment with etanercept only in patients with juvenile idiopathic arthritis (JIA): preliminary data from the German JIA registry.","volume":"68","author":"Horneff","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.tips.2014.05.004","article-title":"Epigenetic mechanisms of importance for drug treatment.","volume":"35","author":"Ivanov","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1002\/art.38341","article-title":"Whole blood gene expression profiling predicts therapeutic response at six months in patients with polyarticular juvenile idiopathic arthritis.","volume":"66","author":"Jiang","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1056\/NEJM200003163421103","article-title":"Etanercept in children with polyarticular juvenile rheumatoid arthritis. pediatric rheumatology collaborative study group.","volume":"342","author":"Lovell","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1056\/NEJMoa0706290","article-title":"Adalimumab with or without methotrexate in juvenile rheumatoid arthritis.","volume":"359","author":"Lovell","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1097\/FPC.0b013e328343dd93","article-title":"PharmGKB summary: methotrexate pathway.","volume":"21","author":"Mikkelsen","year":"2011","journal-title":"Pharmacogenet. Genomics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1097\/FPC.0b013e32833f2cd0","article-title":"Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype.","volume":"20","author":"Moncrieffe","year":"2010","journal-title":"Pharmacogenet. Genomics"},{"key":"B19","first-page":"S102","article-title":"Folate supplementation during methotrexate therapy for rheumatoid arthritis.","volume":"28","author":"Morgan","year":"2010","journal-title":"Clin. Exp. Rheumatol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/tpj.2012.7","article-title":"Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients.","volume":"13","author":"Owen","year":"2012","journal-title":"Pharmacogenomics J."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-3131-y","article-title":"5-Aminoimidazole-4-carboxamide ribonucleotide-transformylase and inosine-triphosphate-pyrophosphatase genes variants predict remission rate during methotrexate therapy in patients with juvenile idiopathic arthritis.","author":"Pastore","year":"2014","journal-title":"Rheumatol. Int."},{"key":"B22","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1136\/adc.88.3.197","article-title":"Use of methotrexate in juvenile idiopathic arthritis.","volume":"88","author":"Ramanan","year":"2003","journal-title":"Arch. Dis. Child."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1101\/gr.129668.111","article-title":"Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition.","volume":"22","author":"Ramsey","year":"2012","journal-title":"Genome Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S0140-6736(07)60363-8","article-title":"Juvenile idiopathic arthritis.","volume":"369","author":"Ravelli","year":"2007","journal-title":"Lancet"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1002\/art.20288","article-title":"A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate.","volume":"50","author":"Ruperto","year":"2004","journal-title":"Arthritis Rheum."},{"key":"B26","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nrrheum.2014.140","article-title":"Pharmacogenetics: can genes determine treatment efficacy and safety in JIA?","volume":"10","author":"Schmeling","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1097\/FPC.0000000000000036","article-title":"Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation.","volume":"24","author":"Senapati","year":"2014","journal-title":"Pharmacogenet. Genomics"},{"key":"B28","doi-asserted-by":"publisher","first-page":"5766","DOI":"10.2174\/138161212803530853","article-title":"Personalized therapies in pediatric inflammatory and autoimmune diseases.","volume":"18","author":"Stocco","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1002\/art.34343","article-title":"Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis.","volume":"64","author":"Wallace","year":"2012","journal-title":"Arthritis Rheum."},{"key":"B30","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/tpj.2012.8","article-title":"Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.","volume":"13","author":"Wang","year":"2013","journal-title":"Pharmacogenomics J."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"deposited":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:22:20Z","timestamp":1429748540000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.frontiersin.org\/Pharmacogenetics_and_Pharmacogenomics\/10.3389\/fphar.2015.00052\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,23]]},"references-count":30,"URL":"https:\/\/doi.org\/10.3389\/fphar.2015.00052","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,23]]}}}