{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:15:37Z","timestamp":1790007337915,"version":"4.0.1"},"reference-count":63,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2015.00176","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T08:20:00Z","timestamp":1440750000000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Traditional Japanese herbal medicines for treatment of odontopathy"],"prefix":"10.3389","volume":"6","author":[{"given":"Kojiro","family":"Yamaguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,8,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1007\/s00280-014-2440-x","article-title":"Double-blind, placebo-controlled, randomized phase II study of TJ-14 (hangeshashinto) for gastric cancer chemotherapy-induced oral mucositis","volume":"73","author":"Aoyama","year":"2014","journal-title":"Cancer Chemother. Pharmacol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S1349-0079(10)80038-6","article-title":"Development of novel therapy for oral diseases using Kampo medicines","author":"Ara","year":"2010","journal-title":"J. Oral. Biosci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/j.1834-7819.2005.tb00363.x","article-title":"Burning mouth syndrome: an update on recent findings","volume":"50","author":"Baker","year":"2005","journal-title":"Aust. Dent. J"},{"key":"B4","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/S1079-2104(98)90204-9","article-title":"Effective of Kampo medicine (Sai-boku-to) in treatment of patients with glossodynia","volume":"86","author":"Bessho","year":"1998","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod"},{"key":"B5","first-page":"101","article-title":"Treatment combined Chinese with Western medicine for microcirculation disease in tongue","volume":"18","author":"Chen","year":"2000","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"key":"B6","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1093\/jn\/133.5.1286","article-title":"Several culinary and medicinal herbs are important sources of dietary antioxidants","volume":"133","author":"Dragland","year":"2003","journal-title":"J. Nutr"},{"key":"B7","doi-asserted-by":"crossref","first-page":"973","DOI":"10.12740\/PP\/19617","article-title":"Burning mouth syndrome: pathogenic and therapeutic concept","volume":"47","author":"Ferensztajn","year":"2013","journal-title":"Psychiatr. Pol."},{"key":"B8","doi-asserted-by":"crossref","first-page":"7175","DOI":"10.1523\/JNEUROSCI.19-16-07175.1999","article-title":"Pain-induced analgesia mediated by mesolimbic reward circuits","volume":"19","author":"Gear","year":"1999","journal-title":"J. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1007\/s11655-014-1882-7","article-title":"Blood stasis syndrome in Japan and its molecular biological analysis","volume":"20","author":"Goto","year":"2014","journal-title":"Chin. J. Integr. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0304-3959(03)00275-6","article-title":"Altered dopamine D2 receptor binding in atypical facial pain","volume":"106","author":"Hagelberg","year":"2003a","journal-title":"Pain"},{"key":"B11","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0304-3959(02)00323-8","article-title":"Striatal dopamine D1 and D2 receptors in burning mouth syndrome","volume":"101","author":"Hagelberg","year":"2003b","journal-title":"Pain"},{"key":"B12","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.ejphar.2004.07.024","article-title":"Striatal dopamine D2 receptors in modulation of pain in humans: a review","volume":"500","author":"Hagelberg","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1142\/S0192415X08006284","article-title":"Kampo medicine, based on traditional meidicine theory, in treating uncured glossodynia: efficacy in five clinical cases","volume":"36","author":"Hijikata","year":"2008","journal-title":"Am. J. Chin. Med."},{"key":"B14","first-page":"333","article-title":"COX-2 as possible target for the inhibition of PGE2 production by Rikko-san in activated macrophage","volume":"22","author":"Horie","year":"2008","journal-title":"In Vivo"},{"key":"B15","doi-asserted-by":"publisher","first-page":"85","DOI":"10.11255\/jjmcp1992.16.85","article-title":"Clinical usefulness of KAMPO (oriental herbal medicine) in the treatment for intractable dental oral diseases for medically compromised patients","volume":"16","author":"Ijima","year":"2007","journal-title":"J. Jpn. Soc. Dent. Med. Compromised Patient"},{"key":"B16","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s10147-013-0529-6","article-title":"Changes of immunological parameters with administration of Japanese Kampo medicine (Juzen-Taihoto\/TJ-48) in patients with advanced pancreatic cancer","volume":"19","author":"Ikemoto","year":"2014","journal-title":"Int. J. Clin. Oncol."},{"key":"B17","first-page":"9","article-title":"The international classification of headache disorders:2nd edition","volume":"24","author":"International Headache Society","year":"2004","journal-title":"Cephalalgia"},{"key":"B18","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0304-3959(00)00409-7","article-title":"Role of the dopaminergic system in chronic pain\u2013a fluorodopa-PET study","volume":"90","author":"J\u00e4\u00e4skel\u00e4inen","year":"2001","journal-title":"Pain"},{"key":"B19","first-page":"b151","article-title":"Management of burning mouth syndrome","volume":"77","author":"Klasser","year":"2011","journal-title":"J. Can. Dent. Assoc."},{"key":"B20","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.coms.2007.12.012","article-title":"Burning mouth syndrome: recognition, understanding, and management","volume":"20","author":"Klasser","year":"2008","journal-title":"Oral Maxillofac. Surg. Clin. North Am"},{"key":"B21","doi-asserted-by":"publisher","first-page":"232","DOI":"10.4021\/wjon263w","article-title":"Topical application of Hangeshashinto (TJ-14) in the treatment of chemotherapy-induced oral mucositis","volume":"1","author":"Kono","year":"2010","journal-title":"World J. Oncol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.pain.2005.03.028","article-title":"Trigeminal small-fiber sensory neuropathy causes burning mouth syndrome","volume":"115","author":"Lauria","year":"2005","journal-title":"Pain"},{"key":"B23","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3851\/imp1597","article-title":"Procyanidin B1 purified from Cinnamomi cortex suppresses hepatitis C virus replication","volume":"20","author":"Li","year":"2010","journal-title":"Antivir. Chem. Chemother"},{"key":"B24","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1142\/S0192415X0500262X","article-title":"Induction of apoptosis in human oral cancer cell lines, OC2 and TSCCa, by chingwaysan","volume":"33","author":"Liao","year":"2005","journal-title":"Am. J. Chin. Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"743153","DOI":"10.1093\/ecam\/nen081","article-title":"Suppressive effect of juzen-taiho-to on lung metastasis of B16 melanoma cells in vivo","volume":"2011","author":"Matsuda","year":"2011","journal-title":"Evid. Based Complement. Alternat. Med"},{"key":"B26","first-page":"193","article-title":"Management of oral cancer patients with Kanpo medicine","volume":"24","author":"Misumi","year":"2013","journal-title":"Ann. Saiseikai Nakatsu Hospital"},{"key":"B27","first-page":"2613","article-title":"Effect of Ninjin-Youei-tou on xerostomia induced by oxybutynin hydrochloride","volume":"43","author":"Miyazaki","year":"1994","journal-title":"Shinyaku Rinsho"},{"key":"B28","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jep.2009.09.048","article-title":"Anxiolytic effect of a herbal medicine, yokukansan, in aged rats: involvement of serotonergic and dopaminergic transmissions in the prefrontal cortex","volume":"127","author":"Mizoguchi","year":"2010","journal-title":"J. Ethnopharmacol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/S0091-3057(03)00131-X","article-title":"Saiko-ka-ryukotsu-borei-to, a herbal medicine, ameliorates chronic stress-induced depressive state in rotarod performance","volume":"75","author":"Mizoguchi","year":"2003","journal-title":"Pharmacol. Biochem. Behav"},{"key":"B30","first-page":"10","article-title":"The Multicenter randomized comparative study of kampo herbal medicine, mai-men-dong-tang (Japanese name Bakumondo-to) compared with bromhexine on salivary secretion in secondary Sj\u00f6gren's syndrome","volume":"14","author":"Nishizawa","year":"2004a","journal-title":"Itami Kampo"},{"key":"B31","first-page":"65","article-title":"Improving effect of Chinese herb medicine mai-men-dong- tang (Japanese name: bakumondo-to) comparative with sicca syndrome in especial salivary patients with secondary Sj\u00f6gren's syndrome in multicenter, well controlled, long-term comparative study","volume":"44","author":"Nishizawa","year":"2003","journal-title":"Nihon Daekisen Gakkaishi"},{"key":"B32","first-page":"62","article-title":"Long-term effects of traditional Chinese herbal medicine, mai-men-dong-tang (Japanese name: bakumondo-to) compared with bromhexine, hydrochloride on sicca syndrome, especially, salivary secretion in patients with primary Sj\u00f6gren's syndrome: a multicenter, randomized well controlled group parallel comparative trial study with bromhexine","volume":"43","author":"Nishizawa","year":"2002","journal-title":"Nihon Daekisen Gakkaishi"},{"key":"B33","first-page":"66","article-title":"Long-term effect of traditional Chinese herbal medicine, mai-men-don-tang on sicca syndrome, especially, salivary secretion in patients with primary Sj\u00f6gren's syndrome: a multicenter, randomized well controlled group-parallel double-blinded study","volume":"45","author":"Nishizawa","year":"2004b","journal-title":"Nihon Daekisen Gakkaishi"},{"key":"B34","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/1472-6882-12-118","article-title":"Protective effect of the Japanese traditional medicine juzentaihoto on myelosuppression induced by the anticancer drug TS-1 and identification of a potential biomarker of this effect","volume":"12","author":"Ogawa","year":"2012","journal-title":"BMC Complement. Altern. Med."},{"key":"B35","first-page":"4423","article-title":"Clinical evaluation of the combined effect of Bu-Zhong-Yi-Qi-Tang (Japanese name, Hochu-ekki-to) or Ren-Shen-Yang-Rong-Tang (Japanese name, Ninjin-youei-to) and the anticancer drug tegafur","volume":"21","author":"Ohara","year":"1993","journal-title":"Yakuri Chiryo"},{"key":"B36","first-page":"134","article-title":"The effect of Kampo medicine on salivary secretion in Sj\u00f6gren's syndrome","volume":"15","author":"Ohno","year":"2006","journal-title":"Kampo Saishin-chiryo"},{"key":"B37","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3937\/kampomed.46.439","article-title":"The effects of Oren-to on stomatitis","volume":"46","author":"Oka","year":"1995","journal-title":"Nihon Toyo Igaku Zasshi"},{"key":"B38","volume-title":"Evidence Reports of Kampo Treatment 2010: 345 Randomized Controlled Trials (EKAT 2010).","author":"Okabe","year":"2010"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/354872","article-title":"A Valid approach in refractory Glossodynia: a single-institution 5-year experience treating with Japanese traditional herbal (kampo) medicine","volume":"2013","author":"Okamoto","year":"2003","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1751-0759-8-6","article-title":"Kampo medicine for palliative care in Japan","volume":"8","author":"Okumi","year":"2014","journal-title":"BioPsychoSoc. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1358\/mf.1998.20.1.485628","article-title":"Increase in monoamine levels caused by emotional stress in mice brain regions is attenuated by Saiko-ka-ryukotsu-borei-to","volume":"20","author":"Sasaki","year":"1998","journal-title":"Methods Find. Exp. Clin. Pharmacol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.phymed.2004.06.014","article-title":"A randomized double-blind placebo-controlled clinical trial of Hochuekkito, a traditional herbal medicine, in the treatment of elderly patients with weakness, N of one and responder restricted design","volume":"12","author":"Satoh","year":"2005","journal-title":"Phytomedicine"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/953459","article-title":"Antiallodynic effect of herbal medicine Yokukansan on peripheral neuropathy in rats with chronic constriction injury","volume":"2013","author":"Suzuki","year":"2012","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"586857","DOI":"10.1155\/2014\/586857","article-title":"The traditional kampo medicine Tokishakuyakusan increases ocular blood flow in healthy subjects","volume":"2014","author":"Takayama","year":"2014","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B45","first-page":"p212","article-title":"A case report: spontaneous regression of tongue cancer in terminal patient","volume":"22","author":"Takita","year":"2011","journal-title":"Ann. Saiseikai Nakatsu Hospital"},{"key":"B46","volume-title":"Chapter, Diagnosis and Treatment 22-52, Introduction to Kampo Japanese Traditional Medicine","author":"The Japan Society for Oriental Medicine","year":"2005"},{"key":"B47","volume-title":"Chapter G5 Crude Drugs 2227- 2243.","author":"The Japanese Pharmacopoeia Sixteenth Edition","year":"2011"},{"key":"B48","volume-title":"9-379, Monographs of Pharmacological Research on Traditional Herbal Medicines (Shoyaku no Yakuso Yakuri).","author":"Toriizuka","year":"2003"},{"key":"B49","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/S0140-6736(00)04140-4","article-title":"Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjogren's syndrome","volume":"357","author":"Tsubota","year":"2001","journal-title":"Lancet"},{"key":"B50","doi-asserted-by":"publisher","first-page":"145","DOI":"10.5631\/jibirin.100.145","article-title":"Treatment of human dry mouth using various medicines","volume":"100","author":"Umemoto","year":"2007","journal-title":"Jibiinkoka Rinsho"},{"key":"B51","doi-asserted-by":"publisher","first-page":"23","DOI":"10.11263\/jsotp.15.04","article-title":"EBM of Kampo medicine in oral surgery","volume":"34","author":"Wang","year":"2015","journal-title":"Oral Therap. Pharmacol."},{"key":"B52","first-page":"43","article-title":"Atypical maxillofacial pain, glossalgia, atypical dental pain","volume":"23","author":"Yamaguchi","year":"2013","journal-title":"Pain Kampo Med"},{"key":"B53","first-page":"87","article-title":"A case report of the tongue cancer successfully controled with Kampo medicine to the pain of meal time","volume":"12","author":"Yamaguchi","year":"2002","journal-title":"Pain Kampo Med"},{"key":"B54","first-page":"73","article-title":"A Case Report of the burning mouth effectively treated with Byakkokaninjinto (TJ-34)","volume":"15","author":"Yamaguchi","year":"2005","journal-title":"Pain Kampo Med."},{"key":"B55","first-page":"56","article-title":"Three cases report of intraoral discomforts with after cancer treatment successfully treated with Ninjinyoeito (TJ108)","volume":"22","author":"Yamaguchi","year":"2012","journal-title":"Pain Kampo Med"},{"key":"B56","first-page":"114","article-title":"Four cases of aphthous stomatitis treated with Kampo Medicine","volume":"18","author":"Yamaguchi","year":"2008","journal-title":"Pain Kampo Med"},{"key":"B57","first-page":"43","article-title":"Effect of Kampo medicine on the burning mouth dyndrome","volume":"17","author":"Yamaguchi","year":"2007","journal-title":"Pain Kampo Med."},{"key":"B58","first-page":"66","article-title":"Kikyou-to (TJ138) effective for a case of Glossodynia with erythrokeratoderma","volume":"19","author":"Yamaguchi","year":"2009","journal-title":"Pain Kampo Med"},{"key":"B59","first-page":"87","article-title":"A case report of the chronic neuralgia-like-pain successfully treated with Keishikajutsubuto(TJ18)induced following the cyber knife therapy to the recurrent mandibular malignant fibrous histiocytoma","volume":"21","author":"Yamaguchi","year":"2011","journal-title":"Pain Kampo Med"},{"key":"B60","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1248\/bpb.31.431","article-title":"Mechanism of salivary secretion enhancement by Byakkokaninjinto","volume":"31","author":"Yanagi","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"B61","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/1472-6882-11-54","article-title":"Modulation of growth and angiogenic potential of oral squamous carcinoma cells in vitro using salvianolic acid B","volume":"11","author":"Yang","year":"2011","journal-title":"BMC Complement. Altern. Med"},{"key":"B62","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.jocn.2006.09.002","article-title":"Burning mouth syndrome as a trigeminal small fiber neuropathy: increased heat and capsaicin receptor TRPV1 in nerve fibers correlates with pain score","volume":"14","author":"Yilmaz","year":"2007","journal-title":"J. Clin. Neurosci"},{"key":"B63","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1601-0825.2010.01706.x","article-title":"Traditional Chinese medicine and oral diseases: today and tomorrow","volume":"17","author":"Zheng","year":"2011","journal-title":"Oral Dis"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T23:15:51Z","timestamp":1567120551000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fphar.2015.00176\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,28]]},"references-count":63,"URL":"https:\/\/doi.org\/10.3389\/fphar.2015.00176","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,28]]}}}