{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:07:03Z","timestamp":1789884423337,"version":"4.0.1"},"reference-count":208,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2015.00227","type":"journal-article","created":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T18:33:07Z","timestamp":1445452387000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Cardiovascular imaging: what have we learned from animal models?"],"prefix":"10.3389","volume":"6","author":[{"given":"Arnoldo","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Fern\u00e1ndez-Friera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Villalba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"L\u00f3pez-Melgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Espa\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Mateo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben A.","family":"Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Jim\u00e9nez-Borreguero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Ruiz-Cabello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,10,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.jss.2009.06.021","article-title":"Animal models of myocardial and vascular injury","volume":"162","author":"Abarbanell","year":"2010","journal-title":"J. Surg. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"310","DOI":"10.2214\/AJR.10.4923","article-title":"A systematic review of the factors affecting accuracy of SUV measurements","volume":"195","author":"Adams","year":"2010","journal-title":"AJR Am. J. Roentgenol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1161\/CIRCULATIONAHA.105.576025","article-title":"Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations","volume":"113","author":"Aletras","year":"2006","journal-title":"Circulation"},{"key":"B4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1002\/mrm.22973","article-title":"Serial MRI characterization of the functional and morphological changes in mouse lung in response to cardiac remodeling following myocardial infarction","volume":"67","author":"Alsaid","year":"2012","journal-title":"Magn. Reson. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"H1708","DOI":"10.1152\/ajpheart.00746.2012","article-title":"Dehydroepiandrosterone restores right ventricular structure and function in rats with severe pulmonary arterial hypertension","volume":"304","author":"Alzoubi","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.atherosclerosis.2011.08.035","article-title":"The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography","volume":"219","author":"Awan","year":"2011","journal-title":"Atherosclerosis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1748-1716.2006.01633.x","article-title":"Oestrogen modulates cardiac ischaemic remodelling through oestrogen receptor-specific mechanisms","volume":"189","author":"Babiker","year":"2007","journal-title":"Acta Physiol. (Oxf)."},{"key":"B8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1055\/s-0037-1616233","article-title":"Atherosclerosis and thrombosis: lessons from animal models","volume":"86","author":"Badimon","year":"2001","journal-title":"Thromb. Haemost."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e23570","DOI":"10.1371\/journal.pone.0023570","article-title":"Albiglutide, a long lasting glucagon-like peptide-1 analog, protects the rat heart against ischemia\/reperfusion injury: evidence for improving cardiac metabolic efficiency","volume":"6","author":"Bao","year":"2011","journal-title":"PLoS ONE"},{"issue":"149","key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00149","article-title":"Cardioprotection by systemic dosing of thymosin beta four following ischemic myocardial injury","volume":"4","author":"Bao","year":"2013","journal-title":"Front. Pharmacol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1161\/01.CIR.0000118494.07530.65","article-title":"Arrhythmogenic right ventricular cardiomyopathy causing sudden cardiac death in boxer dogs: a new animal model of human disease","volume":"109","author":"Basso","year":"2004","journal-title":"Circulation"},{"key":"B12","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1161\/CIRCRESAHA.110.239574","article-title":"Echocardiographic speckle-tracking based strain imaging for rapid cardiovascular phenotyping in mice","volume":"108","author":"Bauer","year":"2011","journal-title":"Circ. Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jacc.2009.02.065","article-title":"Cardiac positron emission tomography","volume":"54","author":"Bengel","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"B14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/978-94-010-0658-3_9","article-title":"Control of cardiac contraction by SR and sarcolemmal Ca fluxes,","volume-title":"Excitation-Contraction Coupling and Cardiac Contractile Force","author":"Bers","year":"2001"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.3181\/0904-MR-135","article-title":"Cardiovascular applications of hyperpolarized contrast media and metabolic tracers","volume":"234","author":"Bhattacharya","year":"2009","journal-title":"Exp. Biol. Med. (Maywood)."},{"key":"B16","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/978-1-60327-372-5_25","article-title":"Animal models for cardiac research,","volume-title":"Handbook of Cardiac Anatomy, Physiology, and Devices, 2nd Edn","author":"Bianco","year":"2009"},{"key":"B17","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.vascn.2010.05.009","article-title":"The utility of the minipig as an animal model in regulatory toxicology","volume":"62","author":"Bode","year":"2010","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"B18","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/978-1-61737-982-6_6","article-title":"Phenotyping cardiac gene therapy in mice","volume":"709","author":"Bostick","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1161\/CIRCULATIONAHA.108.823187","article-title":"Reduced myocardial creatine kinase flux in human myocardial infarction: an in vivo phosphorus magnetic resonance spectroscopy study","volume":"119","author":"Bottomley","year":"2009","journal-title":"Circulation"},{"key":"B20","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1161\/CIRCRESAHA.112.265140","article-title":"Nanobodies targeting mouse\/human VCAM1 for the nuclear imaging of atherosclerotic lesions","volume":"110","author":"Broisat","year":"2012","journal-title":"Circ. Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1741-7007-5-34","article-title":"FishNet: an online database of zebrafish anatomy","volume":"5","author":"Bryson-Richardson","year":"2007","journal-title":"BMC Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1097\/RLI.0b013e3181b2c135","article-title":"Feasibility of functional cardiac MR imaging in mice using a clinical 3 Tesla whole body scanner","volume":"44","author":"Bunck","year":"2009","journal-title":"Invest. Radiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.jcmg.2008.11.018","article-title":"Myocardium at risk after acute infarction in humans on cardiac magnetic resonance: quantitative assessment during follow-up and validation with single-photon emission computed tomography","volume":"2","author":"Carlsson","year":"2009","journal-title":"JACC Cardiovasc. Imaging"},{"key":"B24","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/jmri.10454","article-title":"Assessment of motion gating strategies for mouse magnetic resonance at high magnetic fields","volume":"19","author":"Cassidy","year":"2004","journal-title":"J. Magn. Resonance Imaging"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1164\/rccm.201103-0412OC","article-title":"A novel murine model of severe pulmonary arterial hypertension","volume":"184","author":"Ciuclan","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B26","doi-asserted-by":"crossref","DOI":"10.5772\/51364","article-title":"Study of the murine cardiac mechanical function using magnetic resonance imaging: the current status, challenges, and future perspectives,","volume-title":"Practical Applications in Biomedical Engineering","author":"Constantinides","year":"2013"},{"key":"B27","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1532-429X-13-56","article-title":"Regional contrast agent quantification in a mouse model of myocardial infarction using 3D cardiac T1 mapping","volume":"13","author":"Coolen","year":"2011","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"B28","doi-asserted-by":"publisher","first-page":"C40","DOI":"10.1016\/j.jacc.2005.09.076","article-title":"Atherosclerotic plaque characterization by multidetector row computed tomography angiography","volume":"47","author":"Cordeiro","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1709b","DOI":"10.1093\/eurheartj\/ehr068","article-title":"Imaging of atherosclerosis: magnetic resonance imaging","volume":"32","author":"Corti","year":"2011","journal-title":"Eur. Heart J."},{"key":"B30","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1046\/j.1469-7580.1998.19310105.x","article-title":"Anatomy of the pig heart: comparisons with normal human cardiac structure","volume":"193(Pt 1)","author":"Crick","year":"1998","journal-title":"J. Anat."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1016\/j.jacc.2015.01.045","article-title":"Exercise triggers ARVC phenotype in mice expressing a disease-causing mutated version of human plakophilin-2","volume":"65","author":"Cruz","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1097\/ALN.0b013e3182289988","article-title":"Sevoflurane reduces leukocyte and platelet adhesion after ischemia-reperfusion by protecting the endothelial glycocalyx","volume":"115","author":"Chappell","year":"2011","journal-title":"Anesthesiology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1021\/bi00406a020","article-title":"Defective catabolism and abnormal composition of low-density lipoproteins from mutant pigs with hypercholesterolemia","volume":"27","author":"Checovich","year":"1988","journal-title":"Biochemistry"},{"key":"B34","doi-asserted-by":"publisher","first-page":"715197","DOI":"10.1155\/2012\/715197","article-title":"Application of echocardiography on transgenic mice with cardiomyopathies","volume":"2012","author":"Chen","year":"2012","journal-title":"Biochem. Res. Int."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e51041","DOI":"10.3791\/51041","article-title":"Assessment of right ventricular structure and function in mouse model of pulmonary artery constriction by transthoracic echocardiography","volume":"84","author":"Cheng","year":"2014","journal-title":"J. Vis. Exp."},{"key":"B36","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1172\/JCI118512","article-title":"Genes and physiology: molecular physiology in genetically engineered animals","volume":"97","author":"Chien","year":"1996","journal-title":"J. Clin. Invest."},{"key":"B37","doi-asserted-by":"publisher","first-page":"P129","DOI":"10.1186\/1532-429X-15-S1-P129","article-title":"In vivo validation of an ultra-high field, high temporal resolution myocardial tagging technique for assessment of diastolic function in mice","volume":"15","author":"Chung","year":"2013","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1161\/01.STR.0000190896.67743.b1","article-title":"Identification of culprit lesions after transient ischemic attack by combined 18F fluorodeoxyglucose positron-emission tomography and high-resolution magnetic resonance imaging","volume":"36","author":"Davies","year":"2005","journal-title":"Stroke"},{"key":"B39","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/nbm.1574","article-title":"Effect of chronic hypoxia on pulmonary artery blood velocity in rats as assessed by electrocardiography-triggered three-dimensional time-resolved MR angiography","volume":"24","author":"de La Roque","year":"2011","journal-title":"NMR Biomed."},{"key":"B40","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1183\/09031936.00204813","article-title":"SuHx rat model: partly reversible pulmonary hypertension and progressive intima obstruction","volume":"44","author":"de Raaf","year":"2014","journal-title":"Eur. Respir. J."},{"key":"B41","doi-asserted-by":"publisher","first-page":"783","DOI":"10.2967\/jnumed.106.032789","article-title":"Clinical myocardial perfusion PET\/CT","volume":"48","author":"Di Carli","year":"2007","journal-title":"J. Nucl. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s12350-009-9094-9","article-title":"PET myocardial perfusion and metabolism clinical imaging","volume":"16","author":"Dilsizian","year":"2009","journal-title":"J. Nucl. Cardiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1161\/CIRCHEARTFAILURE.108.814459","article-title":"Large animal models of heart failure: a critical link in the translation of basic science to clinical practice","volume":"2","author":"Dixon","year":"2009","journal-title":"Circ. Heart Fail."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1161\/01.ATV.19.12.2981","article-title":"Dyslipidemia and vascular dysfunction in diabetic pigs fed an atherogenic diet","volume":"19","author":"Dixon","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S0008-6363(98)00073-X","article-title":"Cardiovascular phenotyping in mice","volume":"39","author":"Doevendans","year":"1998","journal-title":"Cardiovasc. Res."},{"key":"B46","first-page":"107","article-title":"Strategies for studying cardiovascular diseases in transgenic mice and gene-targeted mice,","volume-title":"Transgenic Animal Science","author":"Doevendans","year":"1995"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1183\/09031936.00011511","article-title":"Dehydroepiandrosterone reverses chronic hypoxia\/reoxygenation-induced right ventricular dysfunction in rats","volume":"40","author":"Dumas de La Roque","year":"2012","journal-title":"Eur. Respir. J."},{"key":"B48","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1002\/mrm.10210","article-title":"MR tagging early after myocardial infarction in mice demonstrates contractile dysfunction in adjacent and remote regions","volume":"48","author":"Epstein","year":"2002","journal-title":"Magn. Reson. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"e002695","DOI":"10.1161\/CIRCIMAGING.114.002695","article-title":"Assessment of regional myocardial work in rats","volume":"8","author":"Espe","year":"2015","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1161\/01.CIR.98.15.1541","article-title":"Noninvasive in vivo high-resolution magnetic resonance imaging of atherosclerotic lesions in genetically engineered mice","volume":"98","author":"Fayad","year":"1998","journal-title":"Circulation"},{"key":"B51","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s10741-012-9345-8","article-title":"Analyzing left ventricular function in mice with Doppler echocardiography","volume":"18","author":"Fayssoil","year":"2013","journal-title":"Heart Fail. Rev."},{"key":"B52","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1161\/01.CIR.75.5.980","article-title":"The importance of the determination of the myocardial area at risk in the evaluation of the outcome of acute myocardial infarction in patients","volume":"75","author":"Feiring","year":"1987","journal-title":"Circulation"},{"key":"B53","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1093\/ehjci\/jes274","article-title":"Assessment of strain and strain rate by two-dimensional speckle tracking in mice: comparison with tissue Doppler echocardiography and conductance catheter measurements","volume":"14","author":"Ferferieva","year":"2013","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"B54","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.recesp.2012.10.012","article-title":"Imaginando el futuro del diagn\u00f3stico por imagen","volume":"66","author":"Fern\u00e1ndez-Friera","year":"2013","journal-title":"Rev. Esp. Cardiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.jacc.2015.06.023","article-title":"Pathophysiology Underlying the Bimodal Edema Phenomenon After Myocardial Ischemia\/Reperfusion","volume":"66","author":"Fern\u00e1ndez-Jim\u00e9nez","year":"2015a","journal-title":"J. Am. Coll. Cardiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.jacc.2014.11.004","article-title":"Myocardial edema after ischemia\/reperfusion is not stable and follows a bimodal pattern: imaging and histological tissue characterization","volume":"65","author":"Fernandez-Jimenez","year":"2015b","journal-title":"J. Am. Coll. Cardiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1152\/japplphysiol.00924.2004","article-title":"Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse","volume":"98","author":"Finsen","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"H115","DOI":"10.1152\/ajpheart.01222.2010","article-title":"Sex differences in physiological cardiac hypertrophy are associated with exercise-mediated changes in energy substrate availability","volume":"301","author":"Foryst-Ludwig","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1161\/01.CIR.99.3.448","article-title":"Magnetic resonance imaging and invasive evaluation of development of heart failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha","volume":"99","author":"Franco","year":"1999","journal-title":"Circulation"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1016\/j.jacc.2008.01.019","article-title":"The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance","volume":"51","author":"Friedrich","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/B978-0-12-394596-9.00001-9","article-title":"Animal models of atherosclerosis","volume":"105","author":"Fuster","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/S0008-6363(99)00274-6","article-title":"Serial echocardiographic assessment of left ventricular dimensions and function after myocardial infarction in mice","volume":"45","author":"Gao","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1016\/j.jacc.2013.07.037","article-title":"Noninvasive monitoring of serial changes in pulmonary vascular resistance and acute vasodilator testing using cardiac magnetic resonance","volume":"62","author":"Garc\u00eda-\u00c1lvarez","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jcmg.2014.08.012","article-title":"Association of myocardial T1-mapping CMR with hemodynamics and RV performance in pulmonary hypertension","volume":"8","author":"Garc\u00eda-\u00c1lvarez","year":"2015","journal-title":"JACC Cardiovasc. Imaging"},{"key":"B65","doi-asserted-by":"publisher","first-page":"E70","DOI":"10.1093\/ilar.53.1.70","article-title":"Mice anesthesia, analgesia, and care, Part II: anesthetic considerations in preclinical imaging studies","volume":"53","author":"Gargiulo","year":"2012a","journal-title":"ILAR J."},{"key":"B66","doi-asserted-by":"publisher","first-page":"541872","DOI":"10.1155\/2012\/541872","article-title":"PET\/CT imaging in mouse models of myocardial ischemia","volume":"2012","author":"Gargiulo","year":"2012b","journal-title":"J. Biomed. Biotechnol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/ALN.0b013e3181c4a607","article-title":"Isoflurane postconditioning protects against reperfusion injury by preventing mitochondrial permeability transition by an endothelial nitric oxide synthase-dependent mechanism","volume":"112","author":"Ge","year":"2010","journal-title":"Anesthesiology"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.2337\/diabetes.50.7.1654","article-title":"Diabetes-induced accelerated atherosclerosis in swine","volume":"50","author":"Gerrity","year":"2001","journal-title":"Diabetes"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1016\/j.jcmg.2010.09.017","article-title":"Contrast-enhanced ultrasound imaging detects intraplaque neovascularization in an experimental model of atherosclerosis","volume":"3","author":"Giannarelli","year":"2010","journal-title":"JACC Cardiovasc. Imaging"},{"key":"B70","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ymeth.2007.03.012","article-title":"Cardiac magnetic resonance imaging in small rodents using clinical 1.5 T and 3.0 T scanners","volume":"43","author":"Gilson","year":"2007","journal-title":"Methods"},{"key":"B71","doi-asserted-by":"publisher","first-page":"L363","DOI":"10.1152\/ajplung.00212.2011","article-title":"The monocrotaline model of pulmonary hypertension in perspective","volume":"302","author":"Gomez-Arroyo","year":"2012","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"e115604","DOI":"10.1371\/journal.pone.0115604","article-title":"Use of echocardiography reveals reestablishment of ventricular pumping efficiency and partial ventricular wall motion recovery upon ventricular cryoinjury in the zebrafish","volume":"9","author":"Gonz\u00e1lez-Rosa","year":"2014","journal-title":"PLoS ONE"},{"key":"B73","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00249-012-0857-x","article-title":"Cardiac magnetic resonance imaging of rapid VCAM-1 up-regulation in myocardial ischemia-reperfusion injury","volume":"42","author":"Grieve","year":"2013","journal-title":"Eur. Biophys. J."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1096\/fj.04-2558fje","article-title":"17 \u03b2-estradiol transiently disrupts adherens junctions in endothelial cells","volume":"19","author":"Groten","year":"2005","journal-title":"FASEB J"},{"key":"B75","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/S0008-6363(98)00110-2","article-title":"Animal models of human cardiovascular disease, heart failure and hypertrophy","volume":"39","author":"Hasenfuss","year":"1998","journal-title":"Cardiovasc. Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1006\/phrs.1999.0651","article-title":"Experimental models for the study of cardiovascular function and disease","volume":"41","author":"Hearse","year":"2000","journal-title":"Pharmacol. Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1161\/hc0802.104325","article-title":"Progression and regression of atherosclerotic lesions: monitoring with serial noninvasive magnetic resonance imaging","volume":"105","author":"Helft","year":"2002","journal-title":"Circulation"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/S0735-1097(01)01141-X","article-title":"Atherosclerotic aortic component quantification by noninvasive magnetic resonance imaging: an in vivo study in rabbits","volume":"37","author":"Helft","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"B79","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/978-1-60327-372-5_6","article-title":"Comparative cardiac anatomy,","volume-title":"Handbook of Cardiac Anatomy, Physiology, and Devices","author":"Hill","year":"2009"},{"key":"B80","doi-asserted-by":"publisher","first-page":"e396","DOI":"10.1161\/CIRCULATIONAHA.105.579268","article-title":"A clinician's guide to tissue Doppler imaging","volume":"113","author":"Ho","year":"2006","journal-title":"Circulation"},{"key":"B81","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1161\/RES.0b013e3182582523","article-title":"Animal models of heart failure: a scientific statement from the American Heart Association","volume":"111","author":"Houser","year":"2012","journal-title":"Circ. Res."},{"key":"B82","first-page":"23","article-title":"Mouse physiology,","volume-title":"The Mouse in Biomedical Research","author":"Hoyt","year":"2006"},{"key":"B83","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.atherosclerosis.2011.10.006","article-title":"Recombinant HDL(Milano) exerts greater anti-inflammatory and plaque stabilizing properties than HDL(wild-type)","volume":"220","author":"Ibanez","year":"2012","journal-title":"Atherosclerosis"},{"key":"B84","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.1161\/CIRCULATIONAHA.106.679639","article-title":"Early metoprolol administration before coronary reperfusion results in increased myocardial salvage: analysis of ischemic myocardium at risk using cardiac magnetic resonance","volume":"115","author":"Ibanez","year":"2007","journal-title":"Circulation"},{"key":"B85","first-page":"231","article-title":"Changes in parenchymatous organs and in the aorta of rabbits under the influence of animal protein","volume":"18","author":"Ignatowski","year":"1908","journal-title":"Izvestia Imperatorskoi Voenno-Medicinskoi Akademii"},{"key":"B86","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1161\/01.RES.82.4.407","article-title":"Cardiac physiology in transgenic mice","volume":"82","author":"James","year":"1998","journal-title":"Circ. Res."},{"key":"B87","doi-asserted-by":"publisher","first-page":"H2644","DOI":"10.1152\/ajpheart.01291.2005","article-title":"Sex differences in myocardial infarct size are abolished by sarcolemmal KATP channel blockade in rat","volume":"290","author":"Johnson","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1161\/01.RES.82.4.519","article-title":"Murine cardiac function: a cautionary tail","volume":"82","author":"Kass","year":"1998","journal-title":"Circ. Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1002\/mrm.21215","article-title":"T2-prepared SSFP improves diagnostic confidence in edema imaging in acute myocardial infarction compared to turbo spin echo","volume":"57","author":"Kellman","year":"2007","journal-title":"Magn. Reson. Med."},{"key":"B90","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1161\/01.RES.0000155722.17881.dd","article-title":"Detection of vascular adhesion molecule-1 expression using a novel multimodal nanoparticle","volume":"96","author":"Kelly","year":"2005","journal-title":"Circ. Res."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1161\/01.CIR.100.19.1992","article-title":"Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function","volume":"100","author":"Kim","year":"1999","journal-title":"Circulation"},{"key":"B92","doi-asserted-by":"publisher","first-page":"3172","DOI":"10.1161\/01.CIR.99.24.3172","article-title":"Familial hypertrophic cardiomyopathy in maine coon cats: an animal model of human disease","volume":"99","author":"Kittleson","year":"1999","journal-title":"Circulation"},{"key":"B93","first-page":"1255","article-title":"Euglycemic hyperinsulinemic clamp and oral glucose load in stimulating myocardial glucose utilization during positron emission tomography","volume":"33","author":"Knuuti","year":"1992","journal-title":"J. Nucl. Med."},{"key":"B94","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1002\/mrm.20373","article-title":"Myocardial blood flow mapping in mice using high-resolution spin labeling magnetic resonance imaging: influence of ketamine\/xylazine and isoflurane anesthesia","volume":"53","author":"Kober","year":"2005","journal-title":"Magn. Reson. Med."},{"key":"B95","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/01.rli.0000188362.12555.62","article-title":"Gadofluorine-enhanced magnetic resonance imaging of carotid atherosclerosis in Yucatan miniswine","volume":"41","author":"Koktzoglou","year":"2006","journal-title":"Invest. Radiol."},{"key":"B96","first-page":"616","article-title":"Biology and diseases of swine,","volume-title":"Biology and Diseases of Swine","author":"Laber","year":"2002"},{"key":"B97","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/nature10147","article-title":"Heart regeneration","volume":"473","author":"Laflamme","year":"2011","journal-title":"Nature"},{"key":"B98","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1161\/CIRCIMAGING.108.846253","article-title":"Integration of infarct size, tissue perfusion, and metabolism by hybrid cardiac positron emission tomography\/computed tomography: evaluation in a porcine model of myocardial infarction","volume":"2","author":"Lautam\u00e4ki","year":"2009","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"B99","first-page":"246","article-title":"Effects of various anesthetic protocols on 18F-flurodeoxyglucose uptake into the brains and hearts of normal miniature pigs (Sus scrofa domestica)","volume":"51","author":"Lee","year":"2012","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"B100","first-page":"432","article-title":"A comparative anatomic and physiologic overview of the porcine heart","volume":"53","author":"Lelovas","year":"2014","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"B101","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.cpet.2007.12.001","article-title":"Current Trends in Preclinical PET System Design","volume":"2","author":"Levin","year":"2007","journal-title":"PET Clin."},{"key":"B102","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"B103","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1016\/j.jtcvs.2014.04.044","article-title":"Ventricular and pulmonary vascular remodeling induced by pulmonary overflow in a chronic model of pretricuspid shunt","volume":"148","author":"Linardi","year":"2014","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"B104","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1475-2840-5-7","article-title":"Cardiac dysfunction in the diabetic rat: quantitative evaluation using high resolution magnetic resonance imaging","volume":"5","author":"Loganathan","year":"2006","journal-title":"Cardiovasc. Diabetol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/0012-1606(81)90396-1","article-title":"Species- and age-dependent changes in the relative amounts of cardiac myosin isoenzymes in mammals","volume":"84","author":"Lompre","year":"1981","journal-title":"Dev. Biol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/S0008-6363(98)00216-8","article-title":"Chronic myocardial infarction in the mouse: cardiac structural and functional changes","volume":"41","author":"Lutgens","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"B107","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1161\/CIRCULATIONAHA.109.192666","article-title":"Executive summary: heart disease and stroke statistics\u20132010 update: a report from the American Heart Association","volume":"121","author":"Lloyd-Jones","year":"2010","journal-title":"Circulation"},{"key":"B108","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1093\/cvr\/cvp350","article-title":"17beta-Estradiol inhibits matrix metalloproteinase-2 transcription via MAP kinase in fibroblasts","volume":"85","author":"Mahmoodzadeh","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"B109","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/978-3-642-30726-3_2","article-title":"Sex differences in animal models for cardiovascular diseases and the role of estrogen","volume":"214","author":"Mahmoodzadeh","year":"2012","journal-title":"Handb. Exp. Pharmacol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1586\/erc.09.126","article-title":"Cardiovascular MRI in small animals","volume":"8","author":"Makowski","year":"2010","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"B111","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.1161\/CIRCULATIONAHA.104.500546","article-title":"Mechanisms and models in heart failure: the biomechanical model and beyond","volume":"111","author":"Mann","year":"2005","journal-title":"Circulation"},{"key":"B112","doi-asserted-by":"publisher","first-page":"e343","DOI":"10.1016\/j.ddtec.2012.04.004","article-title":"Technologies: preclinical imaging for drug development","volume":"10","author":"Matthews","year":"2013","journal-title":"Drug Discov. Today Technol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jss.2014.11.006","article-title":"Animal model of reversible, right ventricular failure","volume":"194","author":"McKellar","year":"2015","journal-title":"J. Surg. Res."},{"key":"B114","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/ar.1092320402","article-title":"Determination of relative fiber orientation in heart muscle: methodological problems","volume":"232","author":"McLean","year":"1992","journal-title":"Anat. Rec."},{"key":"B115","first-page":"161","article-title":"On the mechanism of compensatory hyperfunction and insufficiency of the heart","volume":"3","author":"Meerson","year":"1961","journal-title":"Cor Vasa"},{"key":"B116","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/s0735-1097(85)80060-7","article-title":"Atrioventricular conduction versus heart size from mouse to whale","volume":"5(2 Pt 1)","author":"Meijler","year":"1985","journal-title":"J. Am. Coll. Cardiol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1007\/s00395-011-0214-8","article-title":"Determination of the myocardial area at risk with pre- versus post-reperfusion imaging techniques in the pig model","volume":"106","author":"Mewton","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"B118","first-page":"H2147","article-title":"Myocardial ischemia and reperfusion: a murine model","volume":"269(6 Pt 2)","author":"Michael","year":"1995","journal-title":"Am. J. Physiol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1161\/ATVBAHA.112.255224","article-title":"Visualization of vascular inflammation in the atherosclerotic mouse by ultrasmall superparamagnetic iron oxide vascular cell adhesion molecule-1-specific nanoparticles","volume":"32","author":"Michalska","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.atherosclerosis.2013.03.019","article-title":"Monitoring plaque inflammation in atherosclerotic rabbits with an iron oxide (P904) and (18)F-FDG using a combined PET\/MR scanner","volume":"228","author":"Millon","year":"2013","journal-title":"Atherosclerosis"},{"key":"B121","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1093\/ejechocard\/jer021","article-title":"Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE\/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography","volume":"12","author":"Mor-Avi","year":"2011","journal-title":"Eur. J. Echocardiogr."},{"key":"B122","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1113\/expphysiol.2012.068577","article-title":"High-resolution echocardiography in the assessment of cardiac physiology and disease in preclinical models","volume":"98","author":"Moran","year":"2013","journal-title":"Exp. Physiol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"239s","DOI":"10.1126\/scitranslmed.3005101","article-title":"Imaging and nanomedicine in inflammatory atherosclerosis","volume":"6","author":"Mulder","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1161\/CIRCULATIONAHA.106.646380","article-title":"Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis","volume":"114","author":"Nahrendorf","year":"2006","journal-title":"Circulation"},{"key":"B125","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/j.jcmg.2009.04.016","article-title":"18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis","volume":"2","author":"Nahrendorf","year":"2009","journal-title":"JACC Cardiovasc. Imaging"},{"key":"B126","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1161\/01.ATV.14.1.133","article-title":"ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree","volume":"14","author":"Nakashima","year":"1994","journal-title":"Arterioscler. Thromb."},{"key":"B127","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1097\/FJC.0000000000000236","article-title":"Effects of single drug and combined short-term administration of sildenafil, pimobendan, and nicorandil on right ventricular function in rats with monocrotaline-induced pulmonary hypertension","volume":"65","author":"Nakata","year":"2015","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"S121","DOI":"10.1007\/s00259-008-0980-1","article-title":"PET and MRI in cardiac imaging: from validation studies to integrated applications","volume":"36","author":"Nekolla","year":"2009","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"B129","doi-asserted-by":"publisher","first-page":"2950","DOI":"10.1093\/eurheartj\/ehu299","article-title":"Cardiovascular disease in Europe 2014: epidemiological update","volume":"35","author":"Nichols","year":"2014","journal-title":"Eur. Heart J."},{"key":"B130","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1007\/s11604-010-0487-0","article-title":"Utility of contrast-enhanced ultrasonography for qualitative imaging of atherosclerosis in Watanabe heritable hyperlipidemic rabbits: initial experimental study","volume":"28","author":"Nitta-Seko","year":"2010","journal-title":"Jpn. J. Radiol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s00109-015-1251-9","article-title":"Carvedilol improves biventricular fibrosis and function in experimental pulmonary hypertension","volume":"93","author":"Okumura","year":"2015","journal-title":"J. Mol. Med."},{"key":"B132","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1146\/annurev-med-041709-133809","article-title":"Imaging of atherosclerosis","volume":"62","author":"Owen","year":"2011","journal-title":"Annu. Rev. Med."},{"key":"B133","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.2967\/jnumed.114.141093","article-title":"Absolute quantitation of myocardial blood flow in human subjects with or without myocardial ischemia using dynamic flurpiridaz F 18 PET","volume":"55","author":"Packard","year":"2014","journal-title":"J. Nucl. Med."},{"key":"B134","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jvc.2010.06.005","article-title":"Cardiomyopathy in Boxer dogs: a retrospective study of the clinical presentation, diagnostic findings and survival","volume":"13","author":"Palermo","year":"2011","journal-title":"J. Vet. Cardiol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1161\/CIRCHEARTFAILURE.108.839761","article-title":"Small animal models of heart failure: development of novel therapies, past and present","volume":"2","author":"Patten","year":"2009","journal-title":"Circ. Heart Fail."},{"key":"B136","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.cardfail.2007.10.024","article-title":"17 Beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload","volume":"14","author":"Patten","year":"2008","journal-title":"J. Card. Fail."},{"key":"B137","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1161\/01.RES.0000144126.57786.89","article-title":"17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase\/Akt signaling","volume":"95","author":"Patten","year":"2004","journal-title":"Circ. Res."},{"key":"B138","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1007\/s12265-014-9564-6","article-title":"Swine model of chronic postcapillary pulmonary hypertension with right ventricular remodeling: long-term characterization by cardiac catheterization, magnetic resonance, and pathology","volume":"7","author":"Pereda","year":"2014","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"B139","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1161\/01.RES.44.4.503","article-title":"Myocardial infarct size and ventricular function in rats","volume":"44","author":"Pfeffer","year":"1979","journal-title":"Circ. Res."},{"key":"B140","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1161\/CIRCIMAGING.109.918524","article-title":"In vivo detection of vulnerable atherosclerotic plaque by MRI in a rabbit model","volume":"3","author":"Phinikaridou","year":"2010","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"B141","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00109-009-0524-6","article-title":"The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle","volume":"88","author":"Piao","year":"2010","journal-title":"J. Mol. Med. (Berl)."},{"key":"B142","volume-title":"Cardiac MR Imaging in Mice: Morphometry and Functional Assessment","author":"Pohlmann","year":"2011"},{"key":"B143","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1126\/science.1077857","article-title":"Heart regeneration in zebrafish","volume":"298","author":"Poss","year":"2002","journal-title":"Science"},{"key":"B144","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/j.1445-5994.1999.tb00734.x","article-title":"Large animal models of heart failure","volume":"29","author":"Power","year":"1999","journal-title":"Aust. N.Z. J. Med."},{"key":"B145","first-page":"139","article-title":"Development of complex atherosclerotic lesions in pigs with inherited hyper-LDL cholesterolemia bearing mutant alleles for apolipoprotein B","volume":"139","author":"Prescott","year":"1991","journal-title":"Am. J. Pathol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"H1765","DOI":"10.1152\/ajpheart.00559.2011","article-title":"New approaches in small animal echocardiography: imaging the sounds of silence","volume":"301","author":"Ram","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1213\/ane.0b013e3181679347","article-title":"Emulsified isoflurane produces cardiac protection after ischemia-reperfusion injury in rabbits","volume":"106","author":"Rao","year":"2008","journal-title":"Anesth. Analg."},{"key":"B148","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1177\/0023677213494373","article-title":"Cardiac magnetic resonance, transthoracic and transoesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats","volume":"47","author":"Richardson","year":"2013","journal-title":"Lab. Anim."},{"key":"B149","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/1532-429X-15-93","article-title":"Clinical implications of cardiac hyperpolarized magnetic resonance imaging","volume":"15","author":"Rider","year":"2013","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"B150","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1532-429X-16-23","article-title":"Non-invasive assessment of cardiac function and pulmonary vascular resistance in an canine model of acute thromboembolic pulmonary hypertension using 4D flow cardiovascular magnetic resonance","volume":"16","author":"Rold\u00e1n-Alzate","year":"2014","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1067\/S0894-7317(03)00471-1","article-title":"Temporal changes in ventricular function assessed echocardiographically in conscious and anesthetized mice","volume":"16","author":"Rottman","year":"2003","journal-title":"J. Am. Soc. Echocardiogr"},{"key":"B152","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/mrm.1910400106","article-title":"Magnetic resonance microimaging for noninvasive quantification of myocardial function and mass in the mouse","volume":"40","author":"Ruff","year":"1998","journal-title":"Magn. Reson. Med."},{"key":"B153","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.carpath.2006.09.001","article-title":"Small animal models of cardiovascular disease: tools for the study of the roles of metabolic syndrome, dyslipidemia, and atherosclerosis","volume":"15","author":"Russell","year":"2006","journal-title":"Cardiovasc. Pathol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1161\/CIRCRESAHA.113.301129","article-title":"The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure","volume":"115","author":"Ryan","year":"2014","journal-title":"Circ. Res."},{"key":"B155","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12968-015-0116-2","article-title":"Optimization of dual-saturation single bolus acquisition for quantitative cardiac perfusion and myocardial blood flow maps","volume":"17","author":"S\u00e1nchez-Gonz\u00e1lez","year":"2015","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"B156","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1038\/nature06803","article-title":"Imaging of atherosclerotic cardiovascular disease","volume":"451","author":"Sanz","year":"2008","journal-title":"Nature"},{"key":"B157","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1067\/S0894-7317(03)00679-5","article-title":"Evaluation of left ventricular diastolic function by pulsed Doppler tissue imaging in mice","volume":"16","author":"Schaefer","year":"2003","journal-title":"J. Am. Soc. Echocardiogr"},{"key":"B158","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.euje.2005.01.007","article-title":"Evaluation of Tissue Doppler Tei index for global left ventricular function in mice after myocardial infarction: comparison with Pulsed Doppler Tei index","volume":"6","author":"Schaefer","year":"2005","journal-title":"Eur. J. Echocardiogr."},{"key":"B159","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.echo.2008.07.001","article-title":"Echocardiography in translational research: of mice and men","volume":"21","author":"Scherrer-Crosbie","year":"2008","journal-title":"J. Am. Soc. Echocardiogr"},{"key":"B160","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1067\/mje.2002.121863","article-title":"Evaluation of left ventricular diastolic function from spectral and color M-mode Doppler in genetically altered mice","volume":"15","author":"Schmidt","year":"2002","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"B161","doi-asserted-by":"publisher","first-page":"12051","DOI":"10.1073\/pnas.0805953105","article-title":"In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance","volume":"105","author":"Schroeder","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B162","doi-asserted-by":"publisher","first-page":"D34","DOI":"10.1016\/j.jacc.2013.10.029","article-title":"Updated clinical classification of pulmonary hypertension","volume":"62","author":"Simonneau","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0720-048X(01)00307-2","article-title":"Magnetic resonance imaging in coronary heart disease","volume":"38","author":"Sinitsyn","year":"2001","journal-title":"Eur. J. Radiol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1002\/mrm.1910390616","article-title":"Cardiac MRI of the normal and hypertrophied mouse heart","volume":"39","author":"Slawson","year":"1998","journal-title":"Magn. Reson. Med."},{"key":"B165","doi-asserted-by":"publisher","first-page":"C69","DOI":"10.1016\/j.jacc.2005.10.067","article-title":"Plaque characterization with optical coherence tomography","volume":"47","author":"Stamper","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1002\/mrm.20327","article-title":"In vivo assessment of absolute perfusion and intracapillary blood volume in the murine myocardium by spin labeling magnetic resonance imaging","volume":"53","author":"Streif","year":"2005","journal-title":"Magn. Reson. Med."},{"key":"B167","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1002\/nbm.1268","article-title":"Cine-MRI versus two-dimensional echocardiography to measure in vivo left ventricular function in rat heart","volume":"21","author":"Stuckey","year":"2008","journal-title":"NMR Biomed."},{"key":"B168","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1161\/CIRCIMAGING.113.000993","article-title":"T(1) mapping detects pharmacological retardation of diffuse cardiac fibrosis in mouse pressure-overload hypertrophy","volume":"7","author":"Stuckey","year":"2014","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"B169","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1007\/s00109-013-1059-4","article-title":"A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension","volume":"91","author":"Sutendra","year":"2013","journal-title":"J. Mol. Med. (Berl)"},{"key":"B170","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1201\/9781420009156.ch9","article-title":"Cardiothoracic and vascular surgery\/chronic intravascular catheterization,","volume-title":"Swine in the Laboratory Surgery, Anesthesia, Imaging, and Experimental Techniques","author":"Swindle","year":"2007"},{"key":"B171","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1152\/physrev.1986.66.3.710","article-title":"Developmental and functional adaptation of contractile proteins in cardiac and skeletal muscles","volume":"66","author":"Swynghedauw","year":"1986","journal-title":"Physiol. Rev"},{"key":"B172","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1161\/01.CIR.94.5.1109","article-title":"Transthoracic echocardiography in models of cardiac disease in the mouse","volume":"94","author":"Tanaka","year":"1996","journal-title":"Circulation"},{"key":"B173","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1152\/physiolgenomics.00041.2003","article-title":"Mouse cardiac surgery: comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies","volume":"16","author":"Tarnavski","year":"2004","journal-title":"Physiol. Genomics"},{"key":"B174","first-page":"357","article-title":"New index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function\u2013a study in normals and dilated cardiomyopathy","volume":"26","author":"Tei","year":"1995","journal-title":"J. Cardiol."},{"key":"B175","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.ijcard.2014.09.005","article-title":"Macitentan treatment retards the progression of established pulmonary arterial hypertension in an animal model","volume":"177","author":"Temple","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"B176","doi-asserted-by":"publisher","first-page":"761","DOI":"10.2967\/jnumed.110.084848","article-title":"Experimental pig model of old myocardial infarction with long survival leading to chronic left ventricular dysfunction and remodeling as evaluated by PET","volume":"52","author":"Teramoto","year":"2011","journal-title":"J. Nucl. Med"},{"key":"B177","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1161\/circimaging.109.887109","article-title":"Noninvasive assessment of murine pulmonary arterial pressure: validation and application to models of pulmonary hypertension","volume":"3","author":"Thibault","year":"2010","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"B178","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1016\/j.jacc.2012.08.001","article-title":"Third universal definition of myocardial infarction","volume":"60","author":"Thygesen","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"B179","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1136\/heartjnl-2012-302775","article-title":"Vasa vasorum and plaque progression, and responses to atorvastatin in a rabbit model of atherosclerosis: contrast-enhanced ultrasound imaging and intravascular ultrasound study","volume":"99","author":"Tian","year":"2013","journal-title":"Heart"},{"key":"B180","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1161\/CIRCIMAGING.112.976076","article-title":"Detecting myocardial ischemia at rest with cardiac phase-resolved blood oxygen level-dependent cardiovascular magnetic resonance","volume":"6","author":"Tsaftaris","year":"2013","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"B181","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.jcmg.2012.01.016","article-title":"Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction","volume":"5","author":"Ugander","year":"2012","journal-title":"JACC Cardiovasc. Imaging"},{"key":"B182","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0008-6363(00)00285-6","article-title":"Experimental evaluation of coronary collateral development","volume":"49","author":"Unger","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"B183","doi-asserted-by":"publisher","first-page":"L401","DOI":"10.1152\/ajplung.00114.2010","article-title":"Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension","volume":"299","author":"Urboniene","year":"2010","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"B184","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0008-6363(98)00069-8","article-title":"Animal models in the study of myocardial ischaemia and ischaemic syndromes","volume":"39","author":"Verdouw","year":"1998","journal-title":"Cardiovasc. Res."},{"key":"B185","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1161\/01.CIR.0000141732.28175.2A","article-title":"In vivo 16-slice, multidetector-row computed tomography for the assessment of experimental atherosclerosis: comparison with magnetic resonance imaging and histopathology","volume":"110","author":"Viles-Gonzalez","year":"2004","journal-title":"Circulation"},{"key":"B186","doi-asserted-by":"publisher","first-page":"H2362","DOI":"10.1152\/ajpheart.00138.2011","article-title":"Differential modulation of right ventricular strain and right atrial mechanics in mild vs. severe pressure overload","volume":"301","author":"Voeller","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B187","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.jcmg.2011.04.020","article-title":"Pioglitazone modulates vascular inflammation in atherosclerotic rabbits noninvasive assessment with FDG-PET-CT and dynamic contrast-enhanced MR imaging","volume":"4","author":"Vucic","year":"2011","journal-title":"JACC Cardiovasc. Imaging"},{"key":"B188","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1136\/hrt.40.4.351","article-title":"Anatomy of human mitral valve in adult cadaver and comparative anatomy of the valve","volume":"40","author":"Walmsley","year":"1978","journal-title":"Br. Heart J."},{"key":"B189","doi-asserted-by":"publisher","first-page":"E321","DOI":"10.1152\/ajpendo.00278.2004","article-title":"Sex differences in the myocardial inflammatory response to ischemia-reperfusion injury","volume":"288","author":"Wang","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B190","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/0021-9150(80)90234-8","article-title":"Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit)","volume":"36","author":"Watanabe","year":"1980","journal-title":"Atherosclerosis"},{"key":"B191","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/BF00196313","article-title":"The structure of the mouse heart in late fetal stages","volume":"194","author":"Webb","year":"1996","journal-title":"Anat. Embryol."},{"key":"B192","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.ultrasmedbio.2006.11.012","article-title":"Imaging of atherosclerosis in WHHL rabbits using high-resolution ultrasound","volume":"33","author":"Wetterholm","year":"2007","journal-title":"Ultrasound Med. Biol."},{"key":"B193","first-page":"351","article-title":"The pig as a model for myocardial ischemia and exercise","volume":"36","author":"White","year":"1986","journal-title":"Lab. Anim. Sci."},{"key":"B194","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1475-2840-6-14","article-title":"Noninvasive and invasive evaluation of cardiac dysfunction in experimental diabetes in rodents","volume":"6","author":"Wichi","year":"2007","journal-title":"Cardiovasc. Diabetol."},{"key":"B195","doi-asserted-by":"publisher","first-page":"H1065","DOI":"10.1152\/ajpheart.00802.2001","article-title":"Analysis of right ventricular function in healthy mice and a murine model of heart failure by in vivo MRI","volume":"283","author":"Wiesmann","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B196","doi-asserted-by":"publisher","first-page":"2956","DOI":"10.1161\/01.CIR.101.25.2956","article-title":"Noninvasive in vivo magnetic resonance imaging of experimental coronary artery lesions in a porcine model","volume":"101","author":"Worthley","year":"2000","journal-title":"Circulation"},{"key":"B197","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1136\/heartjnl-2012-302920c.1","article-title":"Noninvasive estimation of infarct size in a mouse model of myocardial infarction by echocardiographic coronary perfusion","volume":"31","author":"Wu","year":"2012","journal-title":"J. Ultrasound Med."},{"key":"B198","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s13238-011-1016-3","article-title":"Animal models for the atherosclerosis research: a review","volume":"2","author":"Xiangdong","year":"2011","journal-title":"Protein Cell."},{"key":"B199","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1258\/002367704323133628","article-title":"The laboratory rabbit: an animal model of atherosclerosis research","volume":"38","author":"Yanni","year":"2004","journal-title":"Lab. Anim."},{"key":"B200","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1080\/10976640600721767","article-title":"Reperfused myocardial infarction in mice: 3D mapping of late gadolinium enhancement and strain","volume":"8","author":"Young","year":"2006","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"B201","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1475-2840-6-6","article-title":"Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI)","volume":"6","author":"Yu","year":"2007","journal-title":"Cardiovasc. Diabetol."},{"key":"B202","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.echo.2010.05.017","article-title":"An evaluation of transmitral and pulmonary venous Doppler indices for assessing murine left ventricular diastolic function","volume":"23","author":"Yuan","year":"2010","journal-title":"J. Am. Soc. Echocardiogr"},{"key":"B203","doi-asserted-by":"publisher","first-page":"H2106","DOI":"10.1152\/ajpheart.00856.2006","article-title":"Magnetic resonance imaging of progressive cardiomyopathic changes in the db\/db mouse","volume":"292","author":"Yue","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B204","doi-asserted-by":"publisher","first-page":"497841","DOI":"10.1155\/2011\/497841","article-title":"Animal models of cardiovascular diseases","volume":"2011","author":"Zaragoza","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"B205","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1186\/1475-925X-14-S1-S13","article-title":"Establishment and ultrasound characteristics of atherosclerosis in rhesus monkey","volume":"14","author":"Zeng","year":"2015","journal-title":"Biomed. Eng. Online"},{"key":"B206","doi-asserted-by":"publisher","first-page":"H1187","DOI":"10.1152\/ajpheart.00895.2006","article-title":"Validation of the wall motion score and myocardial performance indexes as novel techniques to assess cardiac function in mice after myocardial infarction","volume":"292","author":"Zhang","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B207","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1002\/mrm.10423","article-title":"Assessment of global and regional myocardial function in the mouse using cine and tagged MRI","volume":"49","author":"Zhou","year":"2003","journal-title":"Magn. Reson. Med."},{"key":"B208","doi-asserted-by":"publisher","first-page":"3050","DOI":"10.1161\/01.CIR.99.23.3050","article-title":"Plasminogen activator inhibitor-1 is a major determinant of arterial thrombolysis resistance","volume":"99","author":"Zhu","year":"1999","journal-title":"Circulation"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T19:33:39Z","timestamp":1567280019000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fphar.2015.00227\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,21]]},"references-count":208,"URL":"https:\/\/doi.org\/10.3389\/fphar.2015.00227","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,21]]}}}