{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:11:34Z","timestamp":1785366694185,"version":"3.55.0"},"reference-count":79,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","award":["#APP01128\/10; #APP00280\/12"],"award-info":[{"award-number":["#APP01128\/10; #APP00280\/12"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002784","name":"Canada Excellence Research Chairs, Government of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2016.00048","type":"journal-article","created":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T03:12:52Z","timestamp":1457579572000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Polyphenol-Rich Extract of Syzygium cumini Leaf Dually Improves Peripheral Insulin Sensitivity and Pancreatic Islet Function in Monosodium L-Glutamate-Induced Obese Rats"],"prefix":"10.3389","volume":"7","author":[{"given":"Jonas R.","family":"Sanches","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas M.","family":"Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicyus T.","family":"Chagas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato S.","family":"Gaspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayque A.","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana M.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah M.","family":"Sloboda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison C.","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Dutra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Everardo M.","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula G.","family":"Cappelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Marcus de A.","family":"Paes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,3,10]]},"reference":[{"key":"B1","first-page":"143","article-title":"Hypoglycemic activity of Eugenia jambolana and Ficus bengalensis: mechanism of action.","volume":"5","author":"Achrekar","year":"1991","journal-title":"In Vivo"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; american heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity.","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"B3","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.phymed.2005.03.008","article-title":"In vitro glucose uptake activity of Aegles marmelos and Syzygium cumini by activation of Glut-4, PI3 kinase and PPARgamma in L6 myotubes.","volume":"13","author":"Anandharajan","year":"2006","journal-title":"Phytomedicine"},{"key":"B4","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1080\/01635581.2012.657766","article-title":"Antioxidant and antiproliferative activities of anthocyanin\/ellagitannin-enriched extracts from Syzygium cumini L. (Jamun, the Indian Blackberry).","volume":"64","author":"Aqil","year":"2012","journal-title":"Nutr. Cancer"},{"key":"B5","doi-asserted-by":"crossref","first-page":"317S","DOI":"10.1093\/ajcn\/81.1.317S","article-title":"Polyphenols and disease risk in epidemiologic studies.","volume":"81","author":"Arts","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"B6","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jep.2010.12.014","article-title":"Role of Syzygium cumini seed extract in the chemoprevention of in vivo genomic damage and oxidative stress.","volume":"134","author":"Arun","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/S2221-1691(12)60050-1","article-title":"Syzygium cumini (L.) Skeels: a review of its phytochemical constituents and traditional uses.","volume":"2","author":"Ayyanar","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"B8","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.ctim.2013.03.004","article-title":"Syzygium cumini (L.) Skeels., a novel therapeutic agent for diabetes: folk medicinal and pharmacological evidences.","volume":"21","author":"Ayyanar","year":"2013","journal-title":"Complement. Ther. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"11668","DOI":"10.1021\/jf802152z","article-title":"Active compounds from Lagerstroemia speciosa, insulin-like glucose uptake-stimulatory\/inhibitory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells.","volume":"56","author":"Bai","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1111\/bph.12194","article-title":"Quercetin induces insulin secretion by direct activation of L-type calcium channels in pancreatic beta cells.","volume":"169","author":"Bardy","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1677\/joe.0.0400527","article-title":"Correlation between \u2018Lee index\u2019 and carcass fat content in weanling and adult female rats with hypothalamic lesions.","volume":"40","author":"Bernardis","year":"1968","journal-title":"J. Endocrinol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/BF00207273","article-title":"Ionic mechanisms involved in the regulation of insulin secretion by muscarinic agonists.","volume":"148","author":"Bordin","year":"1995","journal-title":"J. Membr. Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1369\/0022155415583535","article-title":"Alpha-, Delta- and PP-cells: are they the architectural cornerstones of islet structure and co-ordination?","volume":"63","author":"Brereton","year":"2015","journal-title":"J. Histochem. Cytochem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"9817","DOI":"10.1021\/jf902618v","article-title":"Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic beta cells.","volume":"57","author":"Cai","year":"2009","journal-title":"J. Agric. Food Chem."},{"issue":"259","key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00259","article-title":"Syzygium cumini (L.) Skeels: a prominent source of bioactive molecules against cardiometabolic diseases.","volume":"6","author":"Chagas","year":"2015","journal-title":"Front. Pharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.lfs.2011.09.006","article-title":"(-)-Epigallocatechin-3-gallate blocks 3T3-L1 adipose conversion by inhibition of cell proliferation and suppression of adipose phenotype expression.","volume":"89","author":"Chan","year":"2011","journal-title":"Life Sci."},{"issue":"787152","key":"B17","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/787152","article-title":"Myricetin increases hepatic peroxisome proliferator-activated receptor alpha protein expression and decreases plasma lipids and adiposity in rats.","volume":"2012","author":"Chang","year":"2012","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1089\/jmf.2011.2033","article-title":"Myricetin protects against cytokine-induced cell death in RIN-m5f beta cells.","volume":"15","author":"Ding","year":"2012","journal-title":"J. Med. Food"},{"issue":"146","key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-014-0146-3","article-title":"Clinical usefulness of lipid ratios, visceral adiposity indicators, and the triglycerides and glucose index as risk markers of insulin resistance.","volume":"13","author":"Du","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.3736\/jcim20111216","article-title":"Seeds of Syzygium cumini (L.) Skeels: potential for islet regeneration in experimental diabetes.","volume":"9","author":"Dusane","year":"2011","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"key":"B21","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.foodchem.2010.12.156","article-title":"Identification and quantification of phenolic compounds from pomegranate (Punica granatum L.) peel, mesocarp, aril and differently produced juices by HPLC-DAD-ESI\/MS(n).","volume":"127","author":"Fischer","year":"2011","journal-title":"Food Chem."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.jfca.2011.01.008","article-title":"Comparison of ABTS\/DPPH assays to measure antioxidant capacity in popular antioxidant-rich US foods.","volume":"24","author":"Floegel","year":"2011","journal-title":"J. Food Compost. Anal."},{"key":"B23","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.freeradbiomed.2011.06.002","article-title":"Dietary flavonoids: role of (-)-epicatechin and related procyanidins in cell signaling.","volume":"51","author":"Fraga","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.bbrc.2013.12.042","article-title":"Mechanisms underlying hypertriglyceridemia in rats with monosodium L-glutamate-induced obesity: evidence of XBP-1\/PDI\/MTP axis activation.","volume":"443","author":"Franca","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"17118","DOI":"10.1074\/jbc.M407539200","article-title":"A dominant negative peroxisome proliferator-activated receptor-gamma knock-in mouse exhibits features of the metabolic syndrome.","volume":"280","author":"Freedman","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1007\/s00210-003-0836-y","article-title":"L-type Ca2+ channels activation and contraction elicited by myricetin on vascular smooth muscles.","volume":"368","author":"Fusi","year":"2003","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/j.1749-6632.2012.06511.x","article-title":"Flavonoids and metabolic syndrome.","volume":"1259","author":"Galleano","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1172\/JCI116308","article-title":"Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells.","volume":"91","author":"Gembal","year":"1993","journal-title":"J. Clin. Invest."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-015-0441-9","article-title":"Glucomannan and glucomannan plus spirulina added to pork significantly block dietary cholesterol effects on lipoproteinemia, arylesterase activity, and CYP7A1 expression in Zucker fa\/fa rats.","author":"Gonzalez-Torres","year":"2015","journal-title":"J. Physiol. Biochem."},{"key":"B30","doi-asserted-by":"publisher","first-page":"7688","DOI":"10.1021\/jf201039r","article-title":"Phenolic constituents and antioxidant capacity of four underutilized fruits from the Amazon region.","volume":"59","author":"Gordon","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1385\/ENDO:30:2:191","article-title":"Pancreatic islets from hypothalamic obese rats maintain K+ATP channel-dependent but not -independent pathways on glucose-induced insulin release process.","volume":"30","author":"Grassiolli","year":"2006","journal-title":"Endocrine"},{"key":"B32","first-page":"91","article-title":"Syzygium cumini (L.) SKEELS (Myrtaceae) against diabetes\u2013125 years of research.","volume":"63","author":"Helmstadter","year":"2008","journal-title":"Pharmazie"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2015.1067232","article-title":"Baccharis dracunculifolia methanol extract enhances glucose-stimulated insulin secretion in pancreatic islets of monosodium glutamate induced-obesity model rats.","author":"Hocayen","year":"2015","journal-title":"Pharm. Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nature01478","article-title":"Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.","volume":"422","author":"Itoh","year":"2003","journal-title":"Nature"},{"key":"B35","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1177\/1534735411413261","article-title":"Inhibition of radiation-induced DNA damage by jamun, Syzygium cumini, in the cultured splenocytes of mice exposed to different doses of gamma-radiation.","volume":"11","author":"Jagetia","year":"2012","journal-title":"Integr. Cancer Ther."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1021\/jf203431g","article-title":"Antioxidant activity of isolated ellagitannins from red raspberries and cloudberries.","volume":"60","author":"Kahkonen","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1172\/JCI32914","article-title":"FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice.","volume":"118","author":"Kamagate","year":"2008","journal-title":"J. Clin. Invest."},{"key":"B38","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1159\/000214834","article-title":"Green tea (-)-epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice.","volume":"54","author":"Lee","year":"2009","journal-title":"Ann. Nutr. Metab."},{"key":"B39","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S1570-0232(03)00610-X","article-title":"Pharmacokinetic study of ellagic acid in rat after oral administration of pomegranate leaf extract.","volume":"796","author":"Lei","year":"2003","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1002\/bmc.942","article-title":"HPLC analysis and pharmacokinetic study of quercitrin and isoquercitrin in rat plasma after administration of Hypericum japonicum thunb. extract.","volume":"22","author":"Li","year":"2008","journal-title":"Biomed. Chromatogr."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1016\/j.lfs.2007.08.045","article-title":"Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats.","volume":"81","author":"Liu","year":"2007","journal-title":"Life Sci."},{"issue":"176","key":"B42","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-176","article-title":"Long-term fenofibrate treatment impaired glucose-stimulated insulin secretion and up-regulated pancreatic NF-kappa B and iNOS expression in monosodium glutamate-induced obese rats: is that a latent disadvantage?","volume":"9","author":"Liu","year":"2011","journal-title":"J. Transl. Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/S0031-9422(01)00365-X","article-title":"Acylated flavonol glycosides from Eugenia jambolana leaves.","volume":"58","author":"Mahmoud","year":"2001","journal-title":"Phytochemistry"},{"key":"B44","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1016\/j.lfs.2003.10.034","article-title":"Adrenal medullary function and expression of catecholamine-synthesizing enzymes in mice with hypothalamic obesity.","volume":"74","author":"Martins","year":"2004","journal-title":"Life Sci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"B46","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1210\/en.2003-1099","article-title":"Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells.","volume":"145","author":"Merglen","year":"2004","journal-title":"Endocrinology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1210\/endo-110-2-540","article-title":"Evidence that reduced growth hormone secretion observed in monosodium glutamate-treated rats is the result of a deficiency in growth hormone-releasing factor.","volume":"110","author":"Millard","year":"1982","journal-title":"Endocrinology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1159\/000358677","article-title":"Insulin oversecretion in MSG-obese rats is related to alterations in cholinergic muscarinic receptor subtypes in pancreatic islets.","volume":"33","author":"Miranda","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jsbmb.2014.09.024","article-title":"JNK and IKKbeta phosphorylation is reduced by glucocorticoids in adipose tissue from insulin-resistant rats.","volume":"145","author":"Motta","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1271\/bbb.80222","article-title":"Antioxidative activities of galloyl glucopyranosides from the stem-bark of Juglans mandshurica.","volume":"72","author":"Ngoc","year":"2008","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"B51","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1126\/science.164.3880.719","article-title":"Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate.","volume":"164","author":"Olney","year":"1969","journal-title":"Science"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/obr.12229","article-title":"Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies.","volume":"16","author":"O\u2019Neill","year":"2015","journal-title":"Obes. Rev."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.phytochem.2010.03.018","article-title":"Polyphenolic compounds in the fruits of Egyptian medicinal plants (Terminalia bellerica, Terminalia chebula and Terminalia horrida): characterization, quantitation and determination of antioxidant capacities.","volume":"71","author":"Pfundstein","year":"2010","journal-title":"Phytochemistry"},{"key":"B54","doi-asserted-by":"publisher","first-page":"4290","DOI":"10.1021\/jf0502698","article-title":"Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements.","volume":"53","author":"Prior","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.fitote.2009.06.008","article-title":"Assay conditions and validation of a new UV spectrophotometric method using microplates for the determination of polyphenol content.","volume":"80","author":"Pueyo","year":"2009","journal-title":"Fitoterapia"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1016\/j.fct.2005.04.004","article-title":"Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats.","volume":"43","author":"Ravi","year":"2005","journal-title":"Food Chem. Toxicol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1089\/1096620041224067","article-title":"Anti-diabetic activity of Eugenia jambolana seed kernels on streptozotocin-induced diabetic rats.","volume":"7","author":"Ravi","year":"2004","journal-title":"J. Med. Food"},{"key":"B58","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.3390\/molecules13102545","article-title":"Evaluation of the antioxidant activity of Syzygium cumini leaves.","volume":"13","author":"Ruan","year":"2008","journal-title":"Molecules"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.2174\/0929867311320210002","article-title":"Medicinal agents and metabolic syndrome.","volume":"20","author":"Rubio-Ruiz","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"B60","doi-asserted-by":"publisher","first-page":"9386","DOI":"10.1021\/jf201801q","article-title":"Characterization of phenolic components in polar extracts of Eucalyptus globulus Labill. bark by high-performance liquid chromatography-mass spectrometry.","volume":"59","author":"Santos","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"B61","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1007\/BF00257788","article-title":"A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans.","volume":"21","author":"Scott","year":"1981","journal-title":"Diabetologia"},{"key":"B62","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1254\/jphs.11184FP","article-title":"Syzygium cumini ameliorates insulin resistance and beta-cell dysfunction via modulation of PPAR, dyslipidemia, oxidative stress, and TNF-alpha in type 2 diabetic rats.","volume":"119","author":"Sharma","year":"2012","journal-title":"J. Pharmacol. Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1016\/j.fct.2008.03.020","article-title":"Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats.","volume":"46","author":"Sharma","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.jep.2005.10.033","article-title":"Antihyperglycemic effect of the fruit-pulp of Eugenia jambolana in experimental diabetes mellitus.","volume":"104","author":"Sharma","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1590\/S0102-695X2011005000181","article-title":"The toxicity evaluation of Syzygium cumini leaves in rodents.","volume":"22","author":"Silva","year":"2012","journal-title":"Rev. Bras. Farmacogn."},{"key":"B66","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1089\/met.2008.0034","article-title":"The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects.","volume":"6","author":"Simental-Mendia","year":"2008","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"B67","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.jfca.2009.08.020","article-title":"Determination of phenolic composition and antioxidant activity in fruits, rhizomes and leaves of the white strawberry (Fragaria chiloensis spp. chiloensis form chiloensis) using HPLC-DAD\u2013ESI-MS and free radical quenching techniques.","volume":"23","author":"Simirgiotis","year":"2010","journal-title":"J. Food Compost. Anal."},{"issue":"313718","key":"B68","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/313718","article-title":"Management of cardiorenal metabolic syndrome in diabetes mellitus: a phytotherapeutic perspective.","volume":"2014","author":"Song","year":"2014","journal-title":"J. Diabetes Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0031-9384(80)90222-X","article-title":"Does the Lee obesity index measure general obesity?","volume":"25","author":"Stephens","year":"1980","journal-title":"Physiol. Behav."},{"key":"B70","first-page":"401","article-title":"Regulation of ATP\/ADP in pancreatic islets.","volume":"53","author":"Sweet","year":"2004","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.3390\/molecules18032803","article-title":"Characterization of proanthocyanidins from Parkia biglobosa (Jacq.) G. Don. (Fabaceae) by flow injection analysis-electrospray ionization ion trap tandem mass spectrometry and liquid chromatography\/electrospray ionization mass spectrometry.","volume":"18","author":"Tala","year":"2013","journal-title":"Molecules"},{"issue":"127641","key":"B72","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/127641","article-title":"Antiatherosclerotic potential of active principle isolated from Eugenia jambolana in streptozotocin-induced diabetic rats.","volume":"2011","author":"Tanwar","year":"2011","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"150752","key":"B73","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/neq017","article-title":"Myricetin ameliorates defective post-receptor insulin signaling via beta-endorphin signaling in the skeletal muscles of fructose-fed rats.","volume":"2011","author":"Tzeng","year":"2011","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B74","doi-asserted-by":"publisher","first-page":"e98","DOI":"10.1016\/j.diabres.2011.05.030","article-title":"TyG index performs better than HOMA in a Brazilian population: a hyperglycemic clamp validated study.","volume":"93","author":"Vasques","year":"2011","journal-title":"Diabetes Res. Clin. Pract."},{"key":"B75","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1016\/S0021-9258(19)70821-7","article-title":"The production and release of glycerol by adipose tissue incubated in vitro.","volume":"237","author":"Vaughan","year":"1962","journal-title":"J. Biol. Chem."},{"key":"B76","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1590\/1983-084X\/12_181","article-title":"Determina\u00e7\u00e3o dos compostos fen\u00f3licos e da capacidade antioxidante de extratos aquosos e etan\u00f3licos de Jambol\u00e3o (Syzygium cumini L.).","volume":"17","author":"Veber","year":"2015","journal-title":"Rev. Bras. Plantas Med."},{"key":"B77","doi-asserted-by":"publisher","first-page":"3098","DOI":"10.1021\/jf204715q","article-title":"Profiles and alpha-amylase inhibition activity of proanthocyanidins in unripe Manilkara zapota (chiku).","volume":"60","author":"Wang","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"B78","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.nutres.2014.12.009","article-title":"Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes.","volume":"35","author":"Wang","year":"2015","journal-title":"Nutr. Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"7513","DOI":"10.1021\/jf301888y","article-title":"Metabolite profiling of jaboticaba (Myrciaria cauliflora) and other dark-colored fruit juices.","volume":"60","author":"Wu","year":"2012","journal-title":"J. Agric. Food Chem."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"deposited":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T21:12:30Z","timestamp":1655241150000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fphar.2016.00048\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,10]]},"references-count":79,"URL":"https:\/\/doi.org\/10.3389\/fphar.2016.00048","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,10]]}}}