{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:31:05Z","timestamp":1790505065829,"version":"4.1.0"},"reference-count":107,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 MH086638"],"award-info":[{"award-number":["R01 MH086638"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 EB017695"],"award-info":[{"award-number":["U01 EB017695"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS064046"],"award-info":[{"award-number":["R01 NS064046"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DC012947"],"award-info":[{"award-number":["R01 DC012947"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2016.00157","type":"journal-article","created":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T23:28:13Z","timestamp":1465860493000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Multitarget Multiscale Simulation for Pharmacological Treatment of Dystonia in Motor Cortex"],"prefix":"10.3389","volume":"7","author":[{"given":"Samuel A.","family":"Neymotin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Dura-Bernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lakatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence D.","family":"Sanger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Lytton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,6,14]]},"reference":[{"key":"B1","author":"Action","year":"2016","journal-title":"In silico Clinical Trials: How Computer Simulation will Transform the Biomedical Industry"},{"key":"B2","doi-asserted-by":"publisher","first-page":"566","DOI":"10.3171\/2011.8.PEDS11153","article-title":"Deep brain stimulation in children: experience and technical pearls: clinical article","volume":"8","author":"Air","year":"2011","journal-title":"J. Neurosurg. Pediatr."},{"key":"B3","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/nn.2538","article-title":"Sublayer-specific microcircuits of corticospinal and corticostriatal neurons in motor cortex","volume":"13","author":"Anderson","year":"2010","journal-title":"Nat. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s12311-010-0224-3","article-title":"Controlling Ca2+-activated k+ channels with models of Ca2+ buffering in purkinje cells","volume":"11","author":"Anwar","year":"2012","journal-title":"Cerebellum"},{"key":"B5","doi-asserted-by":"publisher","first-page":"7021","DOI":"10.1523\/JNEUROSCI.0011-12.2012","article-title":"Laminarly orthogonal excitation of fast-spiking and low-threshold-spiking interneurons in mouse motor cortex","volume":"32","author":"Apicella","year":"2012","journal-title":"J. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1113\/jphysiol.2012.245688","article-title":"Quantitative interactions between the A-type K+ current and inositol trisphosphate receptors regulate intraneuronal Ca2+ waves and synaptic plasticity","volume":"591","author":"Ashhad","year":"2013","journal-title":"J. Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/nrn2044","article-title":"Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks","volume":"8","author":"Bartos","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.brs.2014.06.003","article-title":"Deep brain stimulation evoked potentials may relate to clinical benefit in childhood dystonia","volume":"7","author":"Bhanpuri","year":"2014","journal-title":"Brain Stimul."},{"key":"B9","volume-title":"Pattern Recognition and Machine Learning.","author":"Bishop","year":"2006"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11910-014-0454-8","article-title":"Update on treatments for dystonia","volume":"14","author":"Bragg","year":"2014","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"B11","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/S0143-4160(96)90064-0","article-title":"What is the concentration of calcium ions in the endoplasmic reticulum?","volume":"19","author":"Bygrave","year":"1996","journal-title":"Cell Calcium"},{"key":"B12","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511541612","volume-title":"The NEURON Book.","author":"Carnevale","year":"2006"},{"key":"B13","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1007\/978-3-319-00846-2_430","article-title":"Dystonia: altered sensorimotor control and vibro-tactile emg-based biofeedback effects","volume-title":"XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013","author":"Casellato","year":"2014"},{"issue":"21","key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2013.00021","article-title":"The motor cortex: a network tuned to 7-14 Hz","volume":"7","author":"Castro-Alamancos","year":"2013","journal-title":"Front. Neural Circuits"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1162\/NECO_a_00602","article-title":"Motor cortex microcircuit simulation based on brain activity mapping","volume":"26","author":"Chadderdon","year":"2014","journal-title":"Neural Comput."},{"key":"B16","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1085\/jgp.117.5.491","article-title":"Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide","volume":"117","author":"Chen","year":"2001","journal-title":"J. Gen. Physiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/BF00994018","article-title":"Support-vector networks","volume":"20","author":"Cortes","year":"1995","journal-title":"Mach. Learn."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1093\/brain\/121.12.2271","article-title":"Functional mapping of human sensorimotor cortex with electrocorticographic spectral analysis. i. alpha and beta event-related desynchronization","volume":"121","author":"Crone","year":"1998","journal-title":"Brain"},{"key":"B19","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1093\/brain\/awr332","article-title":"Oscillations in sensorimotor cortex in movement disorders: an electrocorticography study","volume":"135","author":"Crowell","year":"2012","journal-title":"Brain"},{"key":"B20","doi-asserted-by":"crossref","first-page":"9895","DOI":"10.1073\/pnas.89.20.9895","article-title":"A single-pool inositol 1, 4, 5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration","volume":"89","author":"De Young","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B21","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1177\/1756285612447261","article-title":"Current and future medical treatment in primary dystonia","volume":"5","author":"Delnooz","year":"2012","journal-title":"Ther. Adv. Neurol. Disord."},{"issue":"28","key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00028","article-title":"Restoring behavior via inverse neurocontroller in a lesioned cortical spiking model driving a virtual arm","volume":"10","author":"Dura-Bernal","year":"2016","journal-title":"Front. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"13763","DOI":"10.1073\/pnas.231499798","article-title":"Degeneracy and complexity in biological systems","volume":"98","author":"Edelman","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B24","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1017\/S0317167100038051","article-title":"Systemic therapy of dystonia","volume":"14","author":"Fahn","year":"1987","journal-title":"Can. J. Neurol. Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.neuron.2011.02.025","article-title":"Dense inhibitory connectivity in neocortex","volume":"69","author":"Fino","year":"2011","journal-title":"Neuron"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1113\/jphysiol.2009.168930","article-title":"Inositol-1,4,5-trisphosphate receptor-mediated Ca2+ waves in pyramidal neuron dendrites propagate through hot spots and cold spots","volume":"587","author":"Fitzpatrick","year":"2009","journal-title":"J. Physiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1152\/jn.00412.2001","article-title":"Failure of averaging in the construction of a conductance-based neuron model","volume":"87","author":"Golowasch","year":"2002","journal-title":"J. Neurophysiol."},{"key":"B28","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1113\/jphysiol.1989.sp017488","article-title":"Modulation by intracellular Ca2+ of the hyperpolarization-activated inward current in rabbit single sino-atrial node cells","volume":"409","author":"Hagiwara","year":"1989","journal-title":"J. Physiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1523\/JNEUROSCI.2813-14.2015","article-title":"Distribution and function of HCN channels in the apical dendritic tuft of neocortical pyramidal neurons","volume":"35","author":"Harnett","year":"2015","journal-title":"J. Neurosci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.neuron.2013.06.005","article-title":"Potassium channels control the interaction between active dendritic integration compartments in layer 5 cortical pyramidal neurons","volume":"79","author":"Harnett","year":"2013","journal-title":"Neuron"},{"key":"B31","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/nn.3917","article-title":"The neocortical circuit: themes and variations","volume":"18","author":"Harris","year":"2015","journal-title":"Nat. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e1002107","DOI":"10.1371\/journal.pcbi.1002107","article-title":"Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties","volume":"7","author":"Hay","year":"2011","journal-title":"PLoS Comput. Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/j.1749-6632.2012.06692.x","article-title":"Toward a network model of dystonia","volume":"1265","author":"Hendrix","year":"2012","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1162\/089976600300015475","article-title":"Expanding NEURON's repertoire of mechanisms with NMODL","volume":"12","author":"Hines","year":"2000","journal-title":"Neural Comput."},{"key":"B35","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/01.NT.0000456276.47073.51","article-title":"Darpa: on the hunt for neuroprosthetics to enhance memory","volume":"14","author":"Hiscott","year":"2014","journal-title":"Neurol. Today"},{"key":"B36","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/01.NT.0000458810.78790.d8","article-title":"Priming of intracellular calcium stores in rat ca1 pyramidal neurons","volume":"584","author":"Hong","year":"2007","journal-title":"J. Physiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1523\/JNEUROSCI.4338-12.2013","article-title":"Organization of cortical and thalamic input to pyramidal neurons in mouse motor cortex","volume":"33","author":"Hooks","year":"2013","journal-title":"J. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1109\/MCSE.2007.55","article-title":"Matplotlib: a 2d graphics environment","volume":"9","author":"Hunter","year":"2007","journal-title":"Comput. Sci. Eng."},{"key":"B39","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1523\/JNEUROSCI.10-09-03178.1990","article-title":"Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics","volume":"10","author":"Jahr","year":"1990","journal-title":"J. Neurosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/S1474-4422(06)70574-9","article-title":"Treatment of dystonia","volume":"5","author":"Jankovic","year":"2006","journal-title":"Lancet Neurol."},{"key":"B41","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF01062488","article-title":"Electrocorticograms in man: effect of voluntary movement upon the electrical activity of the precentral gyrus","volume":"183","author":"Jasper","year":"1949","journal-title":"Arch. Psychiatr. Nervenkr."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1002\/mds.23675","article-title":"Abnormal functional connectivity in focal hand dystonia: mutual information analysis in EEG","volume":"26","author":"Jin","year":"2011","journal-title":"Mov. Disord."},{"key":"B43","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.nurt.2008.01.010","article-title":"Mechanisms and targets of deep brain stimulation in movement disorders","volume":"5","author":"Johnson","year":"2008","journal-title":"Neurotherapeutics"},{"key":"B44","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1113\/jphysiol.1987.sp016799","article-title":"Calcium current activation kinetics in isolated pyramidal neurones of the CA1 region of the mature guinea-pig hippocampus","volume":"392","author":"Kay","year":"1987","journal-title":"J. Physiol. (Lond.)"},{"key":"B45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/biomet\/30.1-2.81","article-title":"A new measure of rank correlation","volume":"30","author":"Kendall","year":"1938","journal-title":"Biometrika"},{"key":"B46","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1109\/TNSRE.2011.2178614","article-title":"Electrostimulation as a prosthesis for repair of information flow in a computer model of neocortex","volume":"20","author":"Kerr","year":"2012","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"issue":"39","key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2013.00039","article-title":"Cortical information flow in Parkinson's disease: a composite network\/field model","volume":"7","author":"Kerr","year":"2013","journal-title":"Front. Comput. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"4992","DOI":"10.1523\/JNEUROSCI.4759-11.2012","article-title":"Hierarchical connectivity and connection-specific dynamics in the corticospinal-corticostriatal microcircuit in mouse motor cortex","volume":"32","author":"Kiritani","year":"2012","journal-title":"J. Neurosci."},{"key":"B49","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1080\/01621459.1966.10480879","article-title":"A computer method for calculating kendall's tau with ungrouped data","volume":"61","author":"Knight","year":"1966","journal-title":"J. Am. Stat. Assoc."},{"key":"B50","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/msb.2009.51","article-title":"Systems biology and the Virtual Physiological Human","volume":"5","author":"Kohl","year":"2009","journal-title":"Mol. Syst. Biol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1523\/JNEUROSCI.3664-05.2006","article-title":"Single Ih channels in pyramidal neuron dendrites: properties, distribution, and impact on action potential output","volume":"26","author":"Kole","year":"2006","journal-title":"J. Neurosci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.neuroimage.2005.05.004","article-title":"Electroencephalographic spectral power in writer's cramp patients: evidence for motor cortex malfunctioning during the cramp","volume":"27","author":"Kristeva","year":"2005","journal-title":"Neuroimage"},{"key":"B53","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.neuron.2008.12.020","article-title":"The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex","volume":"61","author":"Lefort","year":"2009","journal-title":"Neuron"},{"key":"B54","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/jtbi.1994.1041","article-title":"Equations for InsP3 receptor-mediated [Ca2+]i oscillations derived from a detailed kinetic model: a Hodgkin-Huxley like formalism","volume":"166","author":"Li","year":"1994","journal-title":"J. Theor. Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/2194-3990-1-7","article-title":"Multiscale modeling for clinical translation in neuropsychiatric disease","volume":"1","author":"Lytton","year":"2014","journal-title":"J. Comput. Surgery"},{"key":"B56","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1097\/WNP.0b013e3180336fc0","article-title":"Tonic-clonic transitions in computer simulation","volume":"24","author":"Lytton","year":"2007","journal-title":"J. Clin. Neurophys."},{"key":"B57","doi-asserted-by":"publisher","first-page":"4795","DOI":"10.1523\/JNEUROSCI.0123-08.2008","article-title":"Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex","volume":"28","author":"Mallet","year":"2008","journal-title":"J. Neurosci."},{"key":"B58","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1113\/jphysiol.1997.sp022031","article-title":"Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex","volume":"500","author":"Markram","year":"1997","journal-title":"J. Physiol."},{"key":"B59","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1152\/jn.1992.68.4.1384","article-title":"A model of the electrophysiological properties of thalamocortical relay neurons","volume":"68","author":"McCormick","year":"1992","journal-title":"J. Neurophysiol."},{"key":"B60","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/cercor\/3.5.387","article-title":"Neurotransmitter control of neocortical neuronal activity and excitability","volume":"3","author":"McCormick","year":"1993","journal-title":"Cereb. Cortex"},{"issue":"28","key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2013.00028","article-title":"Reaction-diffusion in the NEURON simulator","volume":"7","author":"McDougal","year":"2013a","journal-title":"Front. Neuroinform."},{"key":"B62","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jneumeth.2013.09.011","article-title":"Water-tight membranes from neuronal morphology files","volume":"220","author":"McDougal","year":"2013b","journal-title":"J. Neurosci. Methods"},{"key":"B63","doi-asserted-by":"publisher","first-page":"14694","DOI":"10.1073\/pnas.1513716112","article-title":"Intrinsic excitability measures track antiepileptic drug action and uncover increasing\/decreasing excitability over the wake\/sleep cycle","volume":"112","author":"Meisel","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B64","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1023\/B:JCNS.0000004837.81595.b0","article-title":"Dendritic Ih selectively blocks temporal summation of unsynchronized distal inputs in CA1 pyramidal neurons","volume":"16","author":"Migliore","year":"2004","journal-title":"J. Comput. Neurosci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1523\/JNEUROSCI.3886-06.2007","article-title":"Spectral changes in cortical surface potentials during motor movement","volume":"27","author":"Miller","year":"2007","journal-title":"J. Neurosci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.tins.2003.12.008","article-title":"Interneuron diversity series: molecular and genetic tools to study gabaergic interneuron diversity and function","volume":"27","author":"Monyer","year":"2004","journal-title":"Trends Neurosci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.brs.2014.10.014","article-title":"Neuromodulation research and application in the us department of defense","volume":"8","author":"Nelson","year":"2014","journal-title":"Brain Stimul."},{"key":"B68","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1093\/brain\/awn168","article-title":"The basal ganglia and cerebellum interact in the expression of dystonic movement","volume":"131","author":"Neychev","year":"2008","journal-title":"Brain"},{"key":"B69","doi-asserted-by":"publisher","first-page":"e76285","DOI":"10.1371\/journal.pone.0076285","article-title":"Ih tunes theta\/gamma oscillations and cross-frequency coupling in an in silico CA3 model","volume":"8","author":"Neymotin","year":"2013","journal-title":"PLoS ONE"},{"key":"B70","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s10827-010-0253-4","article-title":"Synaptic information transfer in computer models of neocortical columns","volume":"30","author":"Neymotin","year":"2011a","journal-title":"J. Comput. Neurosci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"11733","DOI":"10.1523\/JNEUROSCI.0501-11.2011","article-title":"Ketamine disrupts theta modulation of gamma in a computer model of hippocampus","volume":"31","author":"Neymotin","year":"2011b","journal-title":"J. Neurosci."},{"issue":"19","key":"B72","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2011.00019","article-title":"Emergence of physiological oscillation frequencies in a computer model of neocortex","volume":"5","author":"Neymotin","year":"2011c","journal-title":"Front. Comput. Neurosci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.neuroscience.2015.12.043","article-title":"Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex","volume":"316","author":"Neymotin","year":"2016","journal-title":"Neuroscience"},{"key":"B74","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1162\/NECO_a_00712","article-title":"Neuronal calcium wave propagation varies with changes in endoplasmic reticulum parameters: a computer model","volume":"27","author":"Neymotin","year":"2015","journal-title":"Neural Comput."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1038\/nbt1206-1565","article-title":"What is a support vector machine?","volume":"24","author":"Noble","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0306-4522(94)00334-2","article-title":"Alterations in the brain GABAA\/benzodiazepine receptor-chloride ionophore complex in a genetic model of paroxysmal dystonia: a quantitative autoradiographic analysis","volume":"64","author":"Nobrega","year":"1995","journal-title":"Neuroscience"},{"key":"B77","doi-asserted-by":"publisher","first-page":"e1000456","DOI":"10.1371\/journal.pcbi.1000456","article-title":"Towards reproducible descriptions of neuronal network models","volume":"5","author":"Nordlie","year":"2009","journal-title":"PLoS Comput. Biol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.neubiorev.2012.01.004","article-title":"Using support vector machine to identify imaging biomarkers of neurological and psychiatric disease: a critical review","volume":"36","author":"Orr\u00f9","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B79","first-page":"2825","article-title":"Scikit-learn: machine learning in Python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J. Mach. Learn. Res."},{"key":"B80","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0013-4694(79)90063-4","article-title":"Evaluation of event-related desynchronization (ERD) preceding and following voluntary self-paced movement","volume":"46","author":"Pfurtscheller","year":"1979","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"B81","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1046\/j.1471-4159.1995.64052153.x","article-title":"Regionally selective and age-dependent alterations in benzodiazepine receptor binding in the genetically dystonic hamster","volume":"64","author":"Pratt","year":"1995","journal-title":"J. Neurochem."},{"key":"B82","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/sj.bjp.0704268","article-title":"Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia","volume":"134","author":"Richter","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1146\/annurev.physiol.65.092101.142734","article-title":"Hyperpolarization-activated cation currents: from molecules to physiological function","volume":"65","author":"Robinson","year":"2003","journal-title":"Annu. Rev. Physiol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s10571-005-3060-0","article-title":"Synaptically activated Ca2+ release from internal stores in CNS neurons","volume":"25","author":"Ross","year":"2005","journal-title":"Cell Mol. Neurobiol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/neuro.19.001.2010","article-title":"Control of GABA release at mossy fiber-CA3 connections in the developing hippocampus","volume":"2","author":"Safiulina","year":"2010","journal-title":"Front. Synaptic Neurosci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1136\/jnnp.74.11.1509","article-title":"Childhood onset generalised dystonia can be modelled by increased gain in the indirect basal ganglia pathway","volume":"74","author":"Sanger","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B87","doi-asserted-by":"publisher","first-page":"e89","DOI":"10.1542\/peds.111.1.e89","article-title":"Classification and definition of disorders causing hypertonia in childhood","volume":"111","author":"Sanger","year":"2003","journal-title":"Pediatrics"},{"key":"B88","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1177\/0883073807299975","article-title":"Botulinum toxin type B improves the speed of reaching in children with cerebral palsy and arm dystonia: an open-label, dose-escalation pilot study","volume":"22","author":"Sanger","year":"2007","journal-title":"J. Child Neurol."},{"key":"B89","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1152\/jn.2000.84.5.2458","article-title":"Computational model of the role of sensory disorganization in focal task-specific dystonia","volume":"84","author":"Sanger","year":"2000","journal-title":"J. Neurophysiol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nrn1650","article-title":"Normal and pathological oscillatory communication in the brain","volume":"6","author":"Schnitzler","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"B91","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/0306-4522(92)90166-Y","article-title":"Effects of intracellular calcium chelation on voltage-dependent and calcium-dependent currents in cat neocortical neurons","volume":"47","author":"Schwindt","year":"1992","journal-title":"Neuroscience"},{"key":"B92","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1098\/rstb.2005.1630","article-title":"The importance of being agranular: a comparative account of visual and motor cortex","volume":"360","author":"Shipp","year":"2005","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1016\/S0006-3495(03)74572-X","article-title":"A model of calcium waves in pancreatic and parotid acinar cells","volume":"85","author":"Sneyd","year":"2003","journal-title":"Biophys. J."},{"key":"B94","doi-asserted-by":"publisher","first-page":"e57453","DOI":"10.1371\/journal.pone.0057453","article-title":"Cortical plasticity induced by spike-triggered microstimulation in primate somatosensory cortex","volume":"8","author":"Song","year":"2013","journal-title":"PLoS ONE"},{"key":"B95","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1126\/science.7716524","article-title":"Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrite","volume":"8","author":"Spruston","year":"1995","journal-title":"Science"},{"key":"B96","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1152\/jn.00397.2009","article-title":"Synaptic noise and physiological coupling generate high-frequency oscillations in a hippocampal computational model","volume":"102","author":"Stacey","year":"2009","journal-title":"J. Neurophysiol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S1474-4422(07)70040-6","article-title":"Deep-brain stimulation for dystonia: new twists in assessment","volume":"6","author":"Tarsy","year":"2007","journal-title":"Lancet Neurol."},{"key":"B98","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/0168-5597(94)90126-0","article-title":"Event-related desynchronization and movement-related cortical potentials on the ECoG and EEG","volume":"93","author":"Toro","year":"1994","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.2174\/0929867311320130002","article-title":"Human disease and drug pharmacology, complex as real life","volume":"20","author":"Viayna","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"B100","doi-asserted-by":"publisher","first-page":"441","DOI":"10.2170\/physiolsci.RP009908","article-title":"The Virtual Physiological Human - a European initiative for in silico human modelling","volume":"58","author":"Viceconti","year":"2008","journal-title":"J. Physiol. Sci."},{"key":"B101","author":"Viceconti","year":"2016","journal-title":"In silico Clinical Trials: How Computer Simulation will Transform the Biomedical Industry"},{"key":"B102","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/S0896-6273(02)00968-6","article-title":"Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling","volume":"36","author":"Wang","year":"2002","journal-title":"Neuron"},{"key":"B103","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1152\/jn.00135.2001","article-title":"Pacemaker neurons for the theta rhythm and their synchronization in the septohippocampal reciprocal loop","volume":"87","author":"Wang","year":"2002","journal-title":"J. Neurophysiol."},{"key":"B104","doi-asserted-by":"crossref","first-page":"6402","DOI":"10.1523\/JNEUROSCI.16-20-06402.1996","article-title":"Gamma oscillation by synaptic inhibition in a hippocampal interneuronal network model","volume":"16","author":"Wang","year":"1996","journal-title":"J. Neurosci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/nn2049","article-title":"Top-down laminar organization of the excitatory network in motor cortex","volume":"11","author":"Weiler","year":"2008","journal-title":"Nat. Neurosci."},{"key":"B106","doi-asserted-by":"publisher","first-page":"7298","DOI":"10.1073\/pnas.0800360105","article-title":"Hyperpolarization-activated graded persistent activity in the prefrontal cortex","volume":"105","author":"Winograd","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B107","doi-asserted-by":"publisher","first-page":"e05422","DOI":"10.7554\/elife.05422","article-title":"A genuine layer 4 in motor cortex with prototypical synaptic circuit connectivity","volume":"3","author":"Yamawaki","year":"2014","journal-title":"Elife"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T14:08:27Z","timestamp":1568038107000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fphar.2016.00157\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,14]]},"references-count":107,"URL":"https:\/\/doi.org\/10.3389\/fphar.2016.00157","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,14]]}}}