{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:24:48Z","timestamp":1787027088627,"version":"build-2736575974"},"reference-count":40,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/07331-5"],"award-info":[{"award-number":["2014\/07331-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"DOI":"10.3389\/fphar.2016.00170","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T10:44:12Z","timestamp":1466160252000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":70,"title":["Anti-Inflammatory Properties of Menthol and Menthone in Schistosoma mansoni Infection"],"prefix":"10.3389","volume":"7","author":[{"given":"Mauricio G.","family":"Zaia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00falio di Orlando","family":"Cagnazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina A.","family":"Feitosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson G.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facia H.","family":"Faccioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silmara M.","family":"Allegretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Afonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda de Freitas","family":"Anibal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.imbio.2008.11.017","article-title":"Immunomodulatory effects of curcumin treatment on murine schistosomiasis mansoni","volume":"214","author":"Allam","year":"2009","journal-title":"Immunobiology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.5897\/JMPR12.0750","article-title":"Medicinal plants and their bioactive constituents: a review of bioactivity against Schistosoma mansoni","volume":"7","author":"Castro","year":"2013","journal-title":"J. Med. Plants Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3947\/ic.2013.45.1.32","article-title":"Praziquantel treatment in trematode and cestode infections: an update","volume":"45","author":"Chai","year":"2013","journal-title":"J. Infect. Chemother."},{"key":"B4","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1111\/pim.12087","article-title":"Immunology of human schistosomiasis","volume":"36","author":"Colley","year":"2014","journal-title":"Parasite Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/0020-7519(95)00004-L","article-title":"Schistosome eggs in the portal vein can induced tolerance","volume":"25","author":"Cuison","year":"1995","journal-title":"Int. J. Parasitol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.imbio.2014.03.015","article-title":"Immunological and parasitological parameters in Schistosoma mansoni-infected mice treated with crude extract from the leaves of Mentha \u00d7 piperita L","volume":"8","author":"Dejani","year":"2014","journal-title":"Immunobiology"},{"key":"B7","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.4049\/jimmunol.151.3.1224","article-title":"IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of b7 expression","volume":"151","author":"Ding","year":"1993","journal-title":"J. Immunol."},{"key":"B8","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4269\/ajtmh.1967.16.483","article-title":"An improved perfusion technique for recovering adult schistosomes from laboratory animals","volume":"16","author":"Duvall","year":"1967","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B9","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1046\/j.1365-3156.2001.00811.x","article-title":"Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance? An overview of the evidence","volume":"6","author":"Gryseels","year":"2002","journal-title":"Trop. Med. Int. Health"},{"issue":"89","key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2016.06.024","article-title":"The Schistosoma granuloma: friend or foe?","volume":"4","author":"Hams","year":"2013","journal-title":"Front. Immunol."},{"key":"B11","doi-asserted-by":"crossref","first-page":"775","DOI":"10.4269\/ajtmh.1998.59.775","article-title":"Evolution of Schistosoma haematobium-related pathology over 24 months after treatment with praziquantel among school children in southeastern Tanzania","volume":"59","author":"Hatz","year":"1998","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B12","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.exppara.2009.04.006","article-title":"Schistosoma mansoni: effect of dirtary zinc supplement on egg granuloma in Swiss mice treated with praziquantel","volume":"122","author":"Helmy","year":"2009","journal-title":"Exp. Parasitol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"874","DOI":"10.3181\/00379727-124-31874","article-title":"Antiviral substances in plants of the mint family (labiatae). 3. Peppermint (Mentha piperita) and other mint plants","volume":"124","author":"Herrmann","year":"1967","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"6533","DOI":"10.4049\/jimmunol.167.11.6533","article-title":"Diferential regulation of nitric oxide synthase-2 and arginase-1 by type 1\/2type cytokines in vivo","volume":"167","author":"Hesse","year":"2001","journal-title":"J. Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"6406","DOI":"10.4049\/jimmunol.164.12.6406","article-title":"IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis","volume":"15","author":"Hoffmann","year":"2000","journal-title":"J. Immunol."},{"key":"B16","doi-asserted-by":"crossref","first-page":"932","DOI":"10.4269\/ajtmh.1999.60.932","article-title":"Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers","volume":"60","author":"Ismail","year":"1990","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1590\/S0037-86822000000300009","article-title":"Critical analysis of the estimated number of schistosomiasis mansoni carriers in Brazil","volume":"33","author":"Katz","year":"2000","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"B18","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1046\/j.1365-3024.2001.00420.x","article-title":"Murina schistosomiasis mansoni: coordinate cytokine regulation and differences in cellular immune responses of granuloma cells and splenocytes to endogenous and exogenous schistosome egg antigens","volume":"23","author":"King","year":"2001","journal-title":"Parasite Immunol."},{"key":"B19","first-page":"148","article-title":"Mineral content, essential oil components and biological activity of two mentha species (M. piperita L., M. spicata L.)","volume":"15","author":"Kizil","year":"2010","journal-title":"Turkish J. Field Crops."},{"key":"B20","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1590\/S0034-89102004000100010","article-title":"Atividade antiparasit\u00e1ria do artemether na esquistossomose mans\u00f4nica experimental antischistosomal activity of artemether in experimental Schistosomiasis mansoni","volume":"38","author":"Lescano","year":"2004","journal-title":"Revi. Sa\u00fade P\u00fablica"},{"key":"B21","first-page":"3","article-title":"Pharmacometric evaluation of nine bio-strath herbal remedies","volume":"8","author":"Leslie","year":"1978","journal-title":"Medita"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1128\/CMR.00046-07","article-title":"Current status of vaccines for schistosomiasis","volume":"21","author":"McManus","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"key":"B23","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1590\/S0036-46652011000300007","article-title":"Therapeutic effects of Allium sativum and Allium cepa in Schistosoma mansoni experimental infection","volume":"53","author":"Mantawy","year":"2011","journal-title":"Rev. Inst. Med. Trop."},{"key":"B24","first-page":"1","article-title":"Actividad antiparasitaria de una decocci\u00f3n de Mentha piperita Linn","author":"Naranjo","year":"2006","journal-title":"Revista Cubana de Medicina Militar"},{"key":"B25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2307\/3274166","article-title":"An efficient meted for exposure of mice to cercarie of Schistosoma mansoni","volume":"38","author":"Olivier","year":"1952","journal-title":"Int. J. Parasitol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1590\/S0074-02761992000900011","article-title":"Human schistosomiasis mansoni: studies on in vitro granuloma modulation","volume":"87","author":"Parra","year":"1992","journal-title":"Mem. Ins. Oswaldo Cruz"},{"key":"B27","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","volume":"2","author":"Pearce","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e140147","DOI":"10.1371\/journal.pone.0140147","article-title":"The role of efflux pumps in Schistosoma mansoni praziquantel resistant phenotype","volume":"10","author":"Pinto-Almeida","year":"2015","journal-title":"PLoS ONE"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1056\/NEJMra012396","article-title":"Schistosomiasis","volume":"346","author":"Ross","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1002\/eji.200323501","article-title":"IL-10 is crucial for transition from acute to chronic disease state during infection of mice with Schistosoma mansoni","volume":"33","author":"Sadler","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5402\/2012\/718645","article-title":"Chemical composition, antifungal and antibiofilm activities of the essential oil of Mentha piperita L","volume":"2012","author":"Saharkhiz","year":"2012","journal-title":"ISRN Pharmaceut."},{"key":"B32","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.actatropica.2008.04.006","article-title":"Eosinophils activation status, cytokines and liver fibrosis in Schistosoma mansoni infected patients","volume":"108","author":"Silveira-Lemos","year":"2008","journal-title":"Acta Trop."},{"key":"B33","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.arabjc.2011.01.019","article-title":"Antibacterial and antioxidant activities of Mentha piperita L","volume":"8","author":"Singh","year":"2011","journal-title":"Arabian J. Chem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1046\/j.1365-3024.1998.00150.x","article-title":"The immune responde and immunopathology in infection with Schistosoma mansoni: a key role of major egg antigen Sm-p40","volume":"20","author":"Stadecker","year":"1998","journal-title":"Parasite Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/IAI.72.1.1-12.2004","article-title":"Regulation of granulomatous inflammation in experimental models of schistosomiasis","volume":"72","author":"Stavitsky","year":"2004","journal-title":"Infect. Immun."},{"key":"B36","first-page":"399","article-title":"Automated platelet count in thrombocytopenic patients a comparison of methods","volume":"23","author":"Stibbe","year":"1985","journal-title":"J. Clin. Chem. Clin. Biochem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.1182\/blood-2006-04-015933","article-title":"Schistosoma mansoni infection in eosinophil lineage-ablated mice","volume":"108","author":"Swartz","year":"2006","journal-title":"Blood"},{"key":"B38","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.exppara.2006.05.001","article-title":"Giardia lamblia: the effects of extracts and fractions from Mentha x piperita Lin (Lamiaceae) on trophozoites","volume":"115","author":"Vidal","year":"2007","journal-title":"Exp. Parasitol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1590\/0074-02760150326","article-title":"Susceptibility or resistance of praziquantel in human schistosomiasis: a review","volume":"111","author":"Wang","year":"2012","journal-title":"Parasitol. Res."},{"key":"B40","author":"World Health Organization","year":"2015","journal-title":"Schistosomiasis."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T18:58:17Z","timestamp":1692385097000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fphar.2016.00170\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,17]]},"references-count":40,"URL":"https:\/\/doi.org\/10.3389\/fphar.2016.00170","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,17]]}}}